12 月 31 日凌晨 2 点多，罗永浩在发布会后发文："趁着今晚突然很想说，就赶紧说了，因为 ADHD 的关系" （老罗微博没排版堆在一起，看着太难受了 ，重排如下） "1、我的发布会没有一场是彩排过的，全是没有彩排直接上去硬讲。 2、幻灯片从来没有提前做完过，都是做到开场前，还有百分之三十左右的页面需要再调整。有好几场甚至是 把全场的幻灯片切成前后两大段，交待同事后一半应如何处理后拿着前一半提心吊胆上台。 3、多年以来，看起来没出大问题的，全是靠体力、经验和时灵时不灵的药物支撑。 4、现在我体力已经不太行了，比如连撑两三天不睡觉心脏会明显不适，而且脑子不工作，吃了十几年的专注 达也已经吃最大剂量也不太管用了。 5、为我的发布会做幕后的同事，工作难度全程都是地狱级数的，每次结束后都需要疗伤。 6、如果 ADHD 换药失败，或是不能用锻炼彻底改善体能问题，我不会再举办这种大型活动了，会害人害己。 7、今晚除了愧疚，剩下的部分大都是幸福的 ❤️ 具体表现为：做事容易分心，比如看文档时总忍不住刷手机；做事情虎头蛇尾，计划好的事很难坚持到底；经 常丢三落四，忘事是常态；还爱冲动，说话爱插嘴，做决定不经过脑子，情绪也 ...

Core Viewpoint - The recent study published in Nature identifies rare genetic variants that significantly increase the risk of Attention Deficit Hyperactivity Disorder (ADHD), implicating specific neuronal biology and providing a basis for precision treatment strategies [2][5]. Group 1: Research Findings - The research team analyzed exome sequencing data from 8,895 ADHD patients and 53,780 control individuals, identifying three genes closely associated with ADHD: MAP1A, ANO8, and ANK2 [4]. - The protein interaction network of these genes is enriched with rare mutation risk genes related to other neurodevelopmental disorders, as well as genes involved in cytoskeletal organization, synaptic function, and RNA processing [4]. - In individuals with ADHD, harmful mutations are correlated with lower socioeconomic status and educational levels, with each rare harmful mutation associated with a decrease of 2.25 IQ points in a sample of 962 adults with ADHD [4]. Group 2: Implications for ADHD - The findings suggest that the comorbidity of mental disorders in ADHD is primarily driven by the accumulation of rare mutations in specific genes, rather than a broad load of constraint genes across the genome [5]. - This research provides important evidence for developing targeted treatment strategies for ADHD, emphasizing the role of rare genetic variants in the disorder [5].