Core Insights - The 15th Peking University Digestive Oncology Forum focused on "innovation, precision, and collaboration" in the context of digestive system tumors, emphasizing the importance of translational research and precision treatment in China [1] Group 1: Disease Prevalence and Trends - Asia has a high incidence of digestive system tumors, influenced by genetic backgrounds and dietary habits, with half of the global upper digestive system tumor patients located in China [1] - The incidence rates of the three major digestive system tumors (esophageal cancer, gastric cancer, liver cancer) in China are declining due to improved disease awareness and lifestyle changes [1] Group 2: Diagnosis and Treatment Challenges - Late diagnosis remains a significant issue in China, with low five-year survival rates for esophageal cancer (approximately 30%) and gastric cancer (approximately 40%) [2] - The early diagnosis rate for digestive tract tumors has improved but still requires further enhancement, with a call for increased public screening and early endoscopic examinations [2] Group 3: Advances in Treatment - The field of digestive system tumor treatment is undergoing profound changes, with new technologies, targets, and drugs emerging, presenting both opportunities and challenges [2] - A "BtoB" bidirectional translational research model is proposed to explore new treatment options targeting HER2, EGFR, and CLDN18.2 [2] Group 4: Immunotherapy and Research Directions - Cell therapy and immunotherapy have made significant strides, with a shift from 1.0 to 2.0 in immunotherapy, expanding the beneficiary population for upper digestive tract tumors [3] - A comprehensive clinical-translational-basic research system is advocated to enhance the clinical application of precision treatment for upper digestive tract tumors [3] Group 5: Collaborative Efforts - The high incidence and mortality rates of digestive system tumors in China call for multidisciplinary integration and innovation to drive advancements in diagnosis and treatment, aligning with the "Healthy China 2030" initiative [3]