液态生物芯片技术

Search documents
东方生物液态芯片:打破垄断,引领体外诊断技术变革
Zheng Quan Shi Bao Wang· 2025-06-12 05:47
Core Insights - The company has successfully developed a liquid chip platform that addresses a critical technology bottleneck in the in vitro diagnostic (IVD) field, previously dominated by foreign giants [1][2][3] - The liquid chip technology is recognized as a key area for innovation in China's "13th Five-Year" national science and technology plan, highlighting its importance for future diagnostic advancements [2] - The platform has been implemented in several renowned hospitals in Shanghai and the Southwest region, providing reliable diagnostic support for tumor markers and autoimmune diseases [1][7] Technology and Innovation - The liquid chip technology utilizes special fluorescent polymer microspheres and signal analysis, overcoming high technical barriers that have historically limited domestic capabilities [2][3] - The core breakthrough involves the use of quantum dot materials for microsphere encoding, allowing for the analysis of over 100 coding signals and enhancing the capacity to thousands with 3D encoding technology [2][4] - The company has established a comprehensive intellectual property system covering the entire supply chain from raw materials to end instruments and reagents, eliminating reliance on foreign technologies [3][4] Product Development and Market Expansion - The company has launched the Mplex-MA1600, the first dual-function immunoassay analyzer in the industry, integrating flow fluorescence and chemiluminescence technologies for efficient multi-item and rapid single-item testing [4][5] - Since July 2023, the company has received 13 NMPA registration certificates for reagents in various fields, including tumor markers and autoimmune diseases, with plans to expand the range of detectable markers [5][6] - The liquid chip technology is also being applied in animal testing and food safety, with collaborations with several research institutes to develop diagnostic kits for various pathogens in livestock [6][7] Competitive Advantage - The company has achieved a breakthrough in "higher performance and lower cost" compared to international leader Luminex, thanks to its fully controllable domestic platform [1][7] - The new detection system combines quantum dot encoding microspheres with single-laser detection technology, achieving high throughput (120 samples/hour), high sensitivity (pg/mL level), and high accuracy (CV < 5%) [7] - The compact design of the fully automated detection equipment reduces the footprint by approximately 40% and lowers overall detection costs by about 50%, facilitating widespread adoption [7]