编辑丨王多鱼 排版丨水成文 增强子-启动子 （ enhancer-promoter， E-P） 相互作用，在细胞命运决定过程中调控基因转录。然 而，E-P 相互作用的调控机制，目前仍不清楚。 2025 年 12 月 16 日，中山大学 丁俊军 教授联合 四川大学华西二院 肖雪 教授、南方医科大学深圳眼科 医院 迟玮 教授、徐州医科大学 白津 教授 、 暨南大学中医学院 范丽丽 博士 （ 中山大学 姜少帅 、 刘心 仪 、 章主恒 、 杨明珠 为论文共同第一作者 ） 在 Nature Genetics 期刊 发表了题为： JMJD2 regulates enhancer-promoter interactions via biomolecular condensate formation 的研究论文。 该研究开发 了 可鉴定特定染色质 互作 上蛋白组分 （ Looposome） 的新技术 —— LoopID 。作为目前 唯一的基于染色质结构的蛋白质组学方法， LoopID 技术基于细胞内真实发生的染色质折叠，为解析特定 染色质三维结构如何被介导、如何发挥功能提供了全新的工具。 在这项最新研究中，研究团队提出了一 ...

Core Viewpoint - The article discusses the advancements in CAR-T cell therapy, particularly focusing on enhancing its efficacy against low-antigen expressing cancers through the integration of intrinsically disordered regions (IDR) with CAR molecules [2][4][6]. Group 1: CAR-T Cell Therapy Overview - CAR-T cells have shown unprecedented success in treating hematological malignancies and are being explored for various diseases, including cancers, infections, autoimmune diseases, and fibrosis [2]. - A significant limitation of CAR-T therapy is its low sensitivity to antigens, requiring hundreds of antigen molecules for activation, which restricts its application to cancers with high antigen expression [2][3]. Group 2: Research Findings - A study published by a team from Yale University demonstrated that fusing IDR with CAR molecules enhances the cytotoxicity of CAR-T cells against low-antigen cancers by promoting biomolecular condensation [4][6]. - The research involved constructing CAR-IDR fusion proteins targeting CD19, CD22, and HER2, which improved the binding of CAR-T cells to cancer cell targets and increased the release of cytotoxic factors [6][8]. Group 3: Implications of IDR Integration - The integration of IDR into CAR-T cells resulted in better anti-tumor effects in both hematological and solid tumor models without spontaneous activation in the absence of antigens, indicating a novel mechanism of action [8]. - This approach expands the toolkit for CAR engineering, suggesting that IDR can serve as a new modular element to enhance the anti-tumor efficacy of CAR-T cells [8].