Core Viewpoint - The article discusses the significance of ovarian aging, its implications on female fertility, and highlights a recent study that identifies NCOA7 as a potential target for mitigating ovarian aging and improving reproductive health [2][3][10]. Group 1: Ovarian Aging and Its Implications - Ovarian aging is one of the earliest forms of aging in the human body, leading to a decline in oocyte quantity and quality, which increases the risks of infertility, miscarriage, pregnancy complications, and birth defects [2]. - Factors such as genetic predisposition, autoimmune conditions, medical interventions, and environmental stimuli can accelerate ovarian aging, resulting in premature ovarian insufficiency (POI) [2]. - The global trend of delayed childbirth and extended post-menopausal lifespan underscores the urgent need for interventions to alleviate ovarian aging and enhance quality of life [3]. Group 2: Recent Research Findings - A study published in Nature Aging reveals that NCOA7 plays a crucial role in regulating ovarian aging by mediating the autophagic clearance of stress granules (SG), which are formed under oxidative stress [3][6]. - The research indicates that harmful mutations and reduced expression of NCOA7 are associated with ovarian aging in both physiological and pathological contexts, leading to accelerated cellular aging and decreased fertility in mice [6][8]. - The study suggests that enhancing the autophagic degradation of stress granules through NCOA7 mRNA delivery or rapamycin can mitigate ovarian aging and improve reproductive capacity [8][10].