以下文章来源于肥胖世界ObesityWorld ，作者肥胖世界 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 近年来，随着GLP-1药物掀起的减重热潮，全球制药行业对减肥管线的投入热情空前高涨。面对GLP-1类药物存在的潜在副作用挑战，各大药 企纷纷布局差异化赛道，开发多元机制的减重方案。在注射剂、口服药等传统剂型之外，亦诺微基于其独创OVPENS平台推出了一款突破性外 用减肥产品MVR-EX105（简称EX105）——首个实现局部涂抹的非侵入性外泌体减肥疗法。近期公布的健康人试验数据显示，36名受试者通 过腹部局部使用EX105成功实现精准塑形——腹部体积平均缩减183.9cm³，腰围平均减少3.4cm，初步验证了该技术的有效性。该研究成果已 入选2025年国际肥胖与代谢病外科联合会（IFSO）年会壁报展示。 据亦诺微介绍，EX105基于其专有OVPENS平台开发，采用白色脂肪棕色化机制实现减脂效果。该产品以工程化外泌体作为生物源纳米递送系 统，通过精准设计在外泌 ...

Core Viewpoint - Obesity has become a global epidemic, significantly increasing the risk of metabolic disorders, type 2 diabetes, fatty liver, and cardiovascular diseases, making it a critical public health issue [6][19]. Research Findings - Recent research from East China Normal University and Shanghai Jiao Tong University reveals that local mild hyperthermia can activate the HSF1-A2B1 transcriptional axis, inducing beige fat thermogenesis, effectively preventing and treating obesity, and improving insulin resistance and liver lipid accumulation [7][19]. Mechanism of Action - Fat tissue can be categorized into white, brown, and beige fat, with beige fat having the ability to burn energy when activated [9]. The study focuses on the transformation of white fat to beige fat, known as browning, as a key strategy in combating obesity and metabolic diseases [9][19]. - Local hyperthermia (LHT) was applied using a photothermal hydrogel injected into the white fat area of mice, activated by near-infrared light, achieving a temperature of 41°C ± 0.5°C [11][12]. Safety and Efficacy - Long-term studies in mouse models demonstrated that LHT effectively prevents and treats obesity caused by a high-fat diet without significant side effects, indicating its safety and efficacy for long-term use [12][19]. Genetic Insights - The research identified a specific mutation in the HSF1 gene that correlates with lower BMI and better metabolic profiles among individuals, suggesting that activating the HSF1-A2B1 pathway could have significant clinical implications for obesity prevention and treatment [17][19]. Future Applications - The study opens avenues for developing wearable devices based on LHT technology, potentially providing safer and more effective treatment options for obesity and metabolic diseases, thereby reducing the healthcare burden [19].