Core Viewpoint - The article discusses the transformative potential of adhesive hydrogels in biomedical applications, emphasizing their inherent tissue adhesion properties and the need for controllable degradation rates to enhance their effectiveness [2][10]. Group 1: Advantages of Adhesive Hydrogels - Adhesive hydrogels possess intrinsic tissue adhesion, eliminating the need for additional fixation, making them promising alternatives to traditional sutures and staples [2]. - They are ideal carriers for delivering functional additives such as cells and drugs, enhancing stability and performance compared to conventional hydrogels [2]. - These hydrogels can be utilized in the production of functional wound dressings to promote tissue regeneration and can also repair other medical devices, reducing secondary tissue damage caused by traditional fixation methods [2]. Group 2: Research Findings - A study published by Professor Bu Yazhong's team at Xi'an Jiaotong University revealed a method to control the degradation of adhesive hydrogels by incorporating succinamide esters [3][8]. - The research demonstrated that by adjusting the degradation rate, therapeutic effects varied across different preclinical scenarios, providing practical guidelines for designing biodegradable materials for specific applications [3][10]. - The study established a correlation between in vitro and in vivo degradation patterns, showing that the optimal degradation rate of adhesive hydrogels depends on their intended use, such as rapid degradation for abdominal adhesion prevention and slow degradation for cardiac surgery [6][8]. Group 3: Implications for Future Research - The controllable degradation method developed in this research can be extended to other biomaterials, potentially broadening the applications of adhesive hydrogels in various medical fields [8][10]. - The findings suggest that the degradation speed can be tailored to match the tissue regeneration needs, exemplified by the use of cryogels for liver injury repair, which first stops bleeding and then promotes liver regeneration [6].