Core Viewpoint - The company is facing challenges in its cell and gene therapy CDMO business due to macroeconomic changes, industry conditions, and downstream demand, resulting in low order prices and negative gross margins, although there has been some improvement compared to the previous year [1][2]. Group 1: Company Overview - The company is focused on cell and gene therapy, which is a key development direction in the biopharmaceutical industry, supported by national and local policies [2]. - The company aims to enhance its competitiveness and market penetration by improving R&D efficiency, expanding into new business areas, and optimizing operations [2]. Group 2: Financial Data - The company reported a net loss of RMB 10,515.07 million for the first half of 2025, primarily due to low order prices and the early production stage of its projects [21]. - The company has fully utilized the raised funds for planned investments, with no reported issues in fund management or usage [10][20]. Group 3: Shareholder Information - The company has not disclosed any special arrangements regarding corporate governance or significant changes in major shareholders [3][4]. Group 4: Upcoming Events - The company will hold a performance briefing on August 27, 2025, to discuss its half-year results and address investor questions [5][8].

Core Viewpoint - The report highlights the ongoing challenges faced by the company in its cell and gene therapy CDMO business, including low order prices and high operational costs, while also emphasizing the potential for growth in the industry supported by favorable policies and technological advancements [1][6][11]. Financial Performance - The company reported a revenue of approximately 119.85 million yuan for the first half of 2025, representing a 6.01% increase compared to the same period last year [4]. - The total profit for the period was a loss of approximately 102.77 million yuan, an improvement from a loss of 113.36 million yuan in the previous year [4]. - The net profit attributable to shareholders was approximately -104.57 million yuan, showing a reduction in losses compared to -113.35 million yuan in the same period last year [4][5]. Industry Overview - The cell and gene therapy sector is identified as a key growth area in biomedicine, with significant advancements in technology and increasing clinical applications [7][11]. - The global pipeline for gene therapies has expanded, with over 4,469 gene therapy projects reported as of mid-2025, indicating a robust growth trajectory in the industry [10][11]. - The industry is characterized by a diverse landscape, with both large enterprises and numerous small to medium-sized companies, leading to a competitive environment [7][11]. Technological Advancements - Continuous innovation in gene editing and delivery technologies is crucial for the advancement of cell and gene therapies, with AI playing a significant role in enhancing research efficiency [8][9]. - Recent breakthroughs in stem cell therapy and regenerative medicine are paving the way for new clinical applications, demonstrating the potential for significant market growth [12][13]. Market Dynamics - The investment landscape for cell and gene therapy is showing signs of recovery in China, with a total financing amount of approximately 4.09 billion yuan in the first half of 2025, up from 2.57 billion yuan in the same period of 2024 [11][12]. - Despite the positive trends, the CDMO sector faces challenges due to the complexity and high costs associated with drug development and production, which may hinder rapid revenue growth [11][12]. Regulatory Environment - The government continues to support the cell and gene therapy industry through various policies aimed at promoting innovation and ensuring quality standards in drug development [14].

Core Viewpoint - The report highlights the ongoing challenges faced by He Yuan Biotechnology in its cell and gene therapy CDMO business, including low order prices and high operational costs, despite some improvements compared to the previous year [1][2]. Company Overview - He Yuan Biotechnology is listed on the Shanghai Stock Exchange with the stock code 688238, focusing on cell and gene therapy [2]. - As of the end of the reporting period, the total assets of the company were approximately 2.12 billion RMB, a decrease of 7.23% from the previous year [2]. Financial Performance - The company's revenue for the reporting period was approximately 119.85 million RMB, reflecting a year-on-year increase of 6.01% [3]. - The total profit for the period was a loss of approximately 102.77 million RMB, an improvement from a loss of 113.36 million RMB in the previous year [3]. - The net loss attributable to shareholders was approximately 104.57 million RMB, compared to a loss of 113.35 million RMB in the same period last year [3]. - The cash flow from operating activities showed a loss of approximately 88.50 million RMB, which is an improvement from a loss of 114.63 million RMB in the previous year [3]. - The weighted average return on net assets decreased by 0.69 percentage points to -6.35% [3]. Industry Context - The cell and gene therapy sector is identified as a key development area in the biopharmaceutical industry, supported by various national and local policies [2]. - The company aims to enhance its competitiveness and market penetration by improving R&D efficiency and expanding into new business areas [2].

Core Viewpoint - He Yuan Bio disclosed a research meeting with investors, highlighting its focus on domestic clients and the growth in the cell and gene therapy sector despite challenges in the broader healthcare financing landscape [1][2]. Company Overview - He Yuan Bio hosted an event titled "I am a Shareholder - Walk into the Listed Company" on July 18, 2025, attended by over 10 investors [2]. - The company is led by key personnel including Chairman and General Manager Pan Oudong, and other executives participated in the discussions [1]. Financial Performance - In 2024, the company achieved revenue of 248.15 million yuan, a year-on-year increase of 21.16%, with specific growth in CRO and CDMO segments [4]. - For Q1 2025, revenue was 52.85 million yuan, a decline of 11.29% compared to the previous year, primarily due to a drop in CDMO revenue [4]. Client Distribution - The company primarily serves domestic clients, with plans to expand its CRO services to pharmaceutical enterprises and enhance its international presence in the CDMO sector [3]. Data Security Measures - He Yuan Bio emphasizes data security, having achieved ISO27001 certification and implementing robust data management and protection systems [5]. CDMO Dependency - The company noted that the complexity of new drug development increases reliance on CDMO services, with over 65% of gene therapy companies outsourcing production [6]. Competitive Advantages - He Yuan Bio possesses a comprehensive CRO/CDMO technology platform, advanced GMP production facilities, and a strong project management capability, which collectively enhance its competitive edge in the cell and gene therapy market [6][7][8]. Cash Flow Situation - In 2024, the company reported a net cash flow of -218.09 million yuan, with ongoing challenges in cash flow due to extended payment cycles from clients [9]. - As of Q1 2025, the company continued to experience negative cash flow but anticipates improvement with the recovery of the investment environment [9]. Accounts Receivable and Bad Debt - As of December 31, 2024, the company had accounts receivable of 85 million yuan, with a bad debt provision of 6.96 million yuan, indicating a low risk of bad debts due to a strong client base [9]. Market Trends - In H1 2025, global healthcare financing decreased by 10%, while financing in China's cell and gene therapy sector increased to approximately 409 million USD, reflecting a recovery in this niche market [9].

本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性依法承担法律责任。 登录新浪财经APP 搜索【信披】查看更多考评等级 证券代码：688238 证券简称：和元生物 重要内容提示 公司负责人、主管会计工作负责人及会计机构负责人（会计主管人员）保证季度报告中财务信息的真 实、准确、完整。 第一季度财务报表是否经审计 □是 √否 一、 主要财务数据 (一) 主要会计数据和财务指标 单位：元 币种：人民币 注：财政部于2024年3月发布的《企业会计准则应用指南汇编2024》第十二章"股份支付"明确，股份支 付交易按受益对象确认成本费用。公司根据变更后的会计政策进行追溯调整，追溯调整了上年同期相应 数据。 (二) 非经常性损益项目和金额 √适用 □不适用 公司董事会、监事会及董事、监事、高级管理人员保证季度报告内容的真实、准确、完整，不存在虚假 记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 单位:元 币种:人民币 对公司将《公开发行证券的公司信息披露解释性公告第1号——非经常性损益》未列举的项目认定为非 经常性损益项目且金额重大的，以及将《公 ...

证券之星消息，2025年4月22日和元生物(688238)发布公告称公司于2025年4月18日召开业绩说明会，国 泰海通证券、鹏华基金、招商基金、华安基金、银河基金、上银基金、博远基金、招银国际基金、肇万 资产、长见投资、勤远资产、中金公司（601995）、混沌道然资产、保银投资、中信证券、申万宏源证 券（000562）、兴业证券、东方证券、浙商证券（601878）、华西证券（002926）、天风证券 （601162）参与。 具体内容如下： 问：目前国内CGT行业需求和供给的变化情况如何，处于什么阶段，未来景气度恢复情况怎样？ 答：从政策方面，国家和各地产业发展继续加大对细胞和基因治疗领域的支持力度，出台一系列政策和 产业支持措施。同时，监管部门出台的一系列指南对于药物开发进一步规范，保障了行业长期健康发 展，促进了创新药对于高水平、高规格的CRO/CDMO需求。从技术和管线进度看，细胞和基因治疗领 域的相关产品正大规模走向临床，适应症从肿瘤领域向包括心血管、神经系统、血液学及自身免疫性疾 病等领域拓展。干细胞再生医学转化应用得到支持和推进，基因治疗商业化进程有里程碑式推进，如 2025年4月份，国内首款腺相 ...