Core Insights - The article discusses the role of m6A modification in mRNA degradation and its implications for cancer treatment and aging research [4][12]. Group 1: Mechanism of m6A in mRNA Degradation - m6A is the most common chemical modification on mRNA, acting like a "time bomb" that influences protein synthesis machinery, specifically ribosomes [6]. - The latest research reveals that m6A induces ribosome stalling for over 0.5 seconds at specific codons, which is three times longer than normal, leading to ribosome collisions that enhance mRNA degradation efficiency by up to 70% [6][4]. - Ribosome collisions create unique "double ribosome footprints," which recruit YTHDF proteins to promote mRNA degradation [4][8]. Group 2: Response to Cellular Stress - During cellular stress, such as amino acid depletion, the m6A-mediated mRNA degradation process is paused, allowing the accumulation of stress response mRNAs that help cells recover [4][11]. - This mechanism enables cells to quickly adjust their gene expression profiles, clearing non-essential mRNA when nutrients are abundant while retaining critical survival genes under stress [11][9]. Group 3: Implications for Disease Treatment - The findings provide new perspectives for cancer treatment and anti-aging therapies, suggesting that inhibiting ASCC3 helicase could enhance m6A-mRNA degradation, aiding in the elimination of pro-survival genes in cancer cells [13]. - The m6A regulatory network is closely related to tumor microenvironment adaptation during nutritional stress, indicating potential metabolic control strategies [13]. - Abnormal m6A accumulation has been found in the brain tissue of Alzheimer's patients, suggesting that regulating this pathway may slow neurodegeneration [13][12].