Core Viewpoint - The successful application of the Iberis® RDN system in a high-risk patient with resistant hypertension and chronic kidney disease (CKD) demonstrates a new treatment pathway and clinical evidence for blood pressure control and renal protection [2][3][15] Indications and Treatment Objectives - The case targets patients whose blood pressure remains uncontrolled despite multiple antihypertensive medications and who are at risk of further renal function deterioration. The goal is to explore the feasibility and potential clinical value of radiofrequency renal denervation (RDN) in achieving precise and sustained blood pressure reduction while delaying the progression of renal damage [5][6] Technical Advantages of Radial Access - The use of radial artery access for RDN offers multiple advantages over traditional femoral access, including better patient tolerance, lower risk of puncture site complications, and effective navigation of vascular challenges such as tortuous or narrowed arteries. This successful application expands the options for RDN procedures in high-risk populations [8] Technical Features of Iberis® RDN System - The Iberis® RDN system features a multi-electrode ring-shaped ablation design that ensures good vascular wall adherence and stability, allowing for more uniform energy distribution around the renal artery. This design reduces the risk of thermal damage to surrounding tissues and enhances the safety and efficacy of RDN procedures [10] Evidence Basis: GSR-DEFINE Study Data Support - The clinical practice and efficacy assessment of this case are supported by robust evidence from the global SYMPLICITY registry GSR-DEFINE, which analyzed over 3,500 patients with resistant hypertension, including those with moderate to severe CKD. The study showed an average reduction in office systolic blood pressure of approximately 12-17 mmHg across different CKD groups after three years of follow-up, indicating sustained and clinically significant blood pressure control [12][13] Clinical Significance and Future Outlook - The successful use of the Iberis® RDN system via radial access in patients with resistant hypertension and CKD reaffirms the clinical potential of RDN in high-risk populations. With strict adherence to indications and close follow-up, RDN is not only an effective tool for blood pressure control but also holds promise for renal protection in patients with impaired kidney function. As a key complement to the "blood pressure reduction + target organ protection" strategy, Iberis® RDN will continue to provide long-term, sustainable, and precise treatment options for high-risk patients with resistant hypertension and renal impairment [15]