绿色合成技术

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探求蛋氨酸产业自主突围之路——记山东省科技进步一等奖高品质D,L-蛋氨酸绿色合成关键技术开发及产业化
Zhong Guo Hua Gong Bao· 2025-07-28 03:36
Core Viewpoint - The collaboration between Shandong New Hope Liuhe Amino Acid Co., Zhejiang University, and Tianjin University has successfully developed a key technology for the green synthesis of high-quality D,L-methionine, breaking the long-standing foreign monopoly in the methionine market [1][4]. Group 1: Technology Development - D,L-methionine is a critical limiting amino acid essential for animal feed, promoting growth and immune function in livestock [2]. - The production technology for methionine has been dominated by foreign companies, characterized by complex processes and high technical barriers [2]. - The research team, led by Professor Chen Zhirong, has spent nearly 15 years optimizing the traditional methods for synthesizing methionine [2][3]. Group 2: Production System - The main production methods for D,L-methionine include the hydrolysis method, which has significant environmental challenges and inefficiencies [3]. - The research team has developed a complete production technology system with independent intellectual property rights, focusing on green processes, continuous production, automation, and high-quality output [3][4]. - Key breakthroughs include the development of a full-cycle technology for efficient recycling of by-products, stabilization of product crystallization, and reduction of energy consumption [3]. Group 3: Market Impact - The company has established a production line with an annual capacity of 300,000 tons, significantly impacting the domestic methionine market [1][5]. - The price of methionine in China soared to 110 yuan per kilogram in 2014 due to supply shortages, but after the introduction of New Hope's product, it dropped to around 25 yuan by 2016, providing substantial cost savings for the livestock industry [5]. - The company aims to expand the application fields of methionine, creating new market opportunities for the industry [5][6].
全球Z-L-缬胺酸市场强生产商排名及市场占有率
QYResearch· 2025-05-26 08:57
Core Viewpoint - The global Z-L-Valine market is projected to reach $0.7 billion by 2031, with a compound annual growth rate (CAGR) of 4.8% in the coming years [2]. Market Overview - The global Z-L-Valine market is primarily driven by the pharmaceutical industry's demand for drug synthesis, which accounts for approximately 92.2% of the market [13]. - The leading manufacturers in the Z-L-Valine market include ISOCHEM, Alfa Chemistry, Caming Pharmaceutical, Chemos GmbH, and P&S Chemicals, with the top five companies holding about 58.0% of the market share in 2024 [6]. Product Segmentation - In terms of product purity, the 98% purity segment is the most significant, capturing around 67.7% of the market share [9]. Regional Analysis - The report highlights key production regions and their market shares, focusing on North America, Europe, Japan, Southeast Asia, and China [24]. Driving Factors - The growth of downstream applications, such as targeted drug delivery systems and biodegradable materials, is expected to sustain the demand for Z-L-Valine NCA [16]. - Technological innovations, particularly in controlled polymerization techniques, are crucial for market growth [16]. - Regulatory restrictions on toxic reagents are prompting companies to adopt safer synthesis methods, indirectly promoting market expansion [16]. Challenges - The complexity of production processes and strict synthesis conditions increase equipment investment and energy costs [17]. - Fluctuations in raw material prices directly impact production costs and market competitiveness [18]. - New polymer monomers, such as polylactic acid (PLA) and polycaprolactone (PCL), pose direct competition to Z-L-Valine [19]. Industry Trends - Breakthroughs in green synthesis technologies, such as the promotion of non-phosgene processes, are expected to reduce production risks and enhance capacity [20]. - The development of multifunctional copolymers that integrate fluorescent groups and targeting molecules is a growing trend [21].