Core Viewpoint - Boston Scientific has completed the acquisition of SoniVie, entering the competitive renal denervation (RDN) market, which is expected to benefit millions of patients with hypertension [1][3]. Acquisition Details - Boston Scientific was previously a strategic investor in SoniVie, holding approximately 10% of its shares. The company paid about $360 million for the remaining 90% of shares, with potential regulatory milestone payments of up to $180 million, valuing the total transaction at approximately $600 million (around 4.3 billion RMB) [3]. - The acquisition is seen as a significant advancement in the treatment of hypertension through renal denervation, with positive results from ongoing clinical trials [3]. TIVUS System Overview - The TIVUS intravascular ultrasound system, developed by SoniVie, aims to treat various hypertension diseases through renal denervation [6]. - TIVUS can reduce renal nerve activity and serves as an alternative or adjunct therapy to antihypertensive medications, potentially offering a faster and more effective treatment method compared to radiofrequency energy [9][11]. - The system is designed for a single effective treatment, simplifying the procedure without causing vascular blockage, thus maintaining normal blood flow [13]. Research Progress - The REDUCED-1 pilot study, involving 40 patients, demonstrated the unique 'non-contact' RDN device, which does not require contact with the renal artery wall [14]. - The THRIVE study, approved by the FDA, aims to validate the efficacy and safety of the TIVUS system in treating hypertension patients [15]. RDN Market Overview - The global RDN market was valued at $1.5 billion in 2022 and is projected to reach $3.8 billion by 2030, with a compound annual growth rate (CAGR) of 12.5% from 2024 to 2030 [19]. - Key technologies in RDN include radiofrequency, ultrasound, and micro-infusion, with radiofrequency being the most widely used method [20]. Product Highlights - Recor Medical's Paradise RDN system, approved by the FDA, utilizes high-intensity focused ultrasound to ablate renal sympathetic nerves without direct contact with the vessel wall [21]. - Medtronic's Symplicity Spyral RDN system became the first to receive regulatory approval in the US, EU, and China for hypertension treatment [23]. - New products from domestic companies like Xinmai Medical and Meiliweiye are also entering the market, showcasing innovative solutions for renal denervation [27][31]. Conclusion - The global RDN market is experiencing rapid growth, supported by technological advancements and increased clinical validation. Major players like Boston Scientific and Medtronic hold significant positions, while domestic companies are emerging with innovative products, promising effective treatment options for hypertension patients [32].

合作伙伴征集：2025全球手术机器人大会 报名：首届全球眼科大会 | 展位有限 #收购详情 波士顿科学是SoniVie的战略投资者，持有该公司约 10% 的股权。凭借这一股权，此次交易包括约 3.6亿美元 的预付款，用于收 购尚未持有的 90% 股份，同时还包括高达 1.8亿美元 的潜在监管里程碑付款。 尽管波士顿科学已经持有部分股权，但该公司仍按 6亿美元 的预付款和 2亿美元 的里程碑付款来评估这笔交易，总价值为 6 亿美 元（约合43亿人民币） 。 SoniVie开发了用于血管周围神经去神经的TIVUS系统，该技术有望治疗多种高血压疾病，包括用于高血压治疗的肾动脉去神经术 （RDN）。此次收购将使波士顿科学进入如今竞争激烈的RDN市场。 报名：首届全球心血管大会 | 奖项评选 报名：首届全球骨科大会 | 奖项评选 心未来 2025年3月3日， 波士顿科学公司 （纽约证券交易所代码：BSX）宣布已达成收购医疗器械公司 SoniVie 的协议。SoniVie 公司开发了TIVUS血管内超声系统。TIVUS系统是一项处于试验阶段的技术，旨在通过对血管周围神经进行去神经支配，治疗 多种高血压疾病，包括针对高血压 ...