Core Insights - The study indicates that adipocyte lipolysis activates epithelial hair follicle stem cells through fatty acid metabolic signaling, promoting hair regeneration [4][11] - Local application of monounsaturated fatty acids can activate hair follicle stem cells to enhance hair growth [4][12] Group 1: Research Findings - The research published in Cell Metabolism reveals that skin injury triggers rapid lipolysis in adipocytes through inflammation, leading to hair regeneration [9][11] - Macrophages infiltrate the dermal adipose tissue post-skin injury, promoting the release of free fatty acids from adipocytes via serum amyloid A3 (SAA3) [8][12] - Epithelial hair follicle stem cells (eHFSC) absorb released monounsaturated fatty acids through the fatty acid transporter CD36, activating the transcriptional coactivator Pgc1-α, which enhances mitochondrial function and energy production [8][12] Group 2: Implications for Regeneration - The interaction between macrophages and adipocytes creates a signaling axis that facilitates tissue regeneration through short-range metabolic signaling via free fatty acids [11][12] - The findings suggest that similar regenerative mechanisms induced by fat inflammation may also play a role in other fat-rich organs [11]