该研究揭示了一条 响应睡眠障碍的全新" 脑-肠对话 "神经内分泌调控通路 。研究表明，睡眠障碍可通过" 迷走神经背核 （DMV） - 迷走神经 - 肠道 "信号轴直接调控肠干细胞的功能。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 近日， 郑州大学 的一项新研究登上了 Cell Press 头条。 该研究以： Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction 为题，于 2026 年 2 月 5 日在线发表于 Cell 子刊 Cell Stem Cell ， 郑州大学生命 科学学院 于政权 团队、中国科学院深圳先进技术研究院脑认知与脑疾病研究所 王枫 、中国农业大学 吕聪 及美国加州大学欧文分校 Maksim V. Plikus 为论文共同通讯作者 ，郑州大学 张明鑫 博士，中国农业大学 吴茜 博士和博士生 刘笛 为论文共同第一作者，郑州大学为论文第一单位。 研究团队进一步确定， 迷走神经背核 （ dorsal motor nucleus of ...

Core Viewpoint - Sleep disorders are increasingly recognized as a global public health challenge, significantly increasing the risk of various chronic diseases, particularly those related to the gut, such as inflammatory bowel disease and colorectal cancer [3][4]. Group 1: Research Findings - A new "brain-gut dialogue" neuroendocrine regulatory pathway has been revealed, showing that sleep disorders can directly regulate intestinal stem cell function through the "dorsal motor nucleus of the vagus (DMV) - vagus nerve - gut" axis [4]. - The research team constructed a mouse model of sleep deprivation and found that the DMV is a key neural cluster highly sensitive to sleep deprivation, with sleep loss leading to abnormal activation of DMV neurons and increased acetylcholine release to the gut [7]. - Excessive serotonin (5-HT) levels in the gut, resulting from sleep deprivation, significantly impair the regenerative capacity of intestinal stem cells, with a notable decrease in their numbers and epithelial renewal ability observed after just two days of sleep deprivation [7][8]. Group 2: Implications and Interventions - Approximately 95% of the body's serotonin originates from the gut, and its imbalance due to sleep disorders may not only damage the gut barrier but also affect other organs like the liver, pancreas, and cardiovascular system, potentially driving multi-organ dysfunction [8]. - Various intervention strategies targeting this pathway have shown protective effects, including atropine to block muscarinic receptor signaling, the specific HTR4 antagonist GR113808, and the antioxidant vitamin C, which can alleviate gut damage caused by sleep disorders [8][10].