Core Insights - The lipid-lowering market is projected to reach $35 billion, with some drugs entering the long-term cardiovascular event risk reduction (CVRR) prevention field [1][2] - Two significant lipid-lowering drugs are expected to report critical Phase III results in 2026, targeting PCSK9 and Lp(a) [1][2] - The development of cardiovascular and cardiac drugs is entering a harvest phase, with a focus on Phase III progress [1] Group 1: Lipid-Lowering Drugs and Market Potential - Novartis' PCSK9 small nucleic acid Leqvio and ASO drug Pelacarsen are under close observation for their Phase III trials, which could expand the market for lipid-lowering treatments [1][2] - The potential success of Novartis' VICTORION trials could signify a shift of PCSK9 from merely lowering cholesterol to long-term cardiovascular protection, with expectations of exceeding $6 billion in future market potential [2] - Merck's MK-0616, the first oral cyclic peptide PCSK9 entering Phase III, is anticipated to influence the long-term trajectory of the PCSK9 market [2] Group 2: Breakthroughs in Other Lipid-Lowering Targets - Arrowhead Pharmaceuticals' Plozasiran (ARO-APOC3) is set for FDA approval for treating familial chylomicronemia syndrome (FCS), marking a significant advancement in the siRNA field [3] - Eli Lilly's Lp(a) small molecule inhibitor Muvalaplin has initiated Phase III trials, aiming to enroll 10,450 participants, with completion expected by 2031 [3] - The Lp(a) field is becoming a competitive space with multiple large pharmaceutical companies advancing their candidates into Phase III trials, indicating a robust development landscape [3] Group 3: Direct-to-Consumer (DTC) Transformation - Major pharmaceutical companies like Eli Lilly, AbbVie, and Pfizer are launching online Direct-to-Consumer platforms, signaling a shift in drug sales strategies [4] - This transformation aims to break traditional barriers between serious medical endpoints and consumer markets, potentially attracting more self-paying users [4] - The focus on chronic disease management is expected to yield significant market share in the future [4]