Financial Data and Key Metrics Changes - The company experienced an uplift of approximately $60 million from Q3 to Q4, driven by three primary factors including the Genomics England contract which contributed around $7 million in Q4 compared to $2 million in Q3 [1][2] - The foreign exchange (FX) impact was a drag of $5-$7 million, which is 1% less than previously predicted, affecting absolute dollar amounts but having minimal impact on growth and earnings per share (EPS) [3] Business Line Data and Key Metrics Changes - The life sciences instrumentation side has shown good activity, with seasonal uplift expected rather than a significant budget flush [2][12] - The reagents business, particularly from BioLegend, faced modest impacts from government shutdowns, but the pharma biotech sector has shown signs of recovery [5][8] - The software segment has grown over 20% each quarter, significantly exceeding guidance, driven by diligent investment and customer engagement [19][21] Market Data and Key Metrics Changes - The U.S. market for EUROIMMUN has increased from 5% to 15-20% of total revenue since acquisition, with expectations to reach 40-45% as more assays are introduced [36] - The China diagnostics market is projected to stabilize, with expectations of it contributing 5-6% to total revenue, while autoimmune testing is anticipated to grow significantly [43][44] Company Strategy and Development Direction - The company is focusing on leveraging AI and machine learning in drug discovery and development, positioning itself as a critical player in the future of pharmaceutical research [22][31] - Strategic acquisitions will continue, with a focus on sensible and financially sound opportunities, as demonstrated by the recent acquisition of ACD/Labs [57] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the recovery in the pharma biotech sector, indicating that increased discussions and activity are signs of normalization [15][16] - The company is confident in its 2026 growth projections of 2-3% and 28% margins, accounting for stable market conditions and the impact of calendarization on China [54][56] Other Important Information - The company has been actively integrating AI across its product lines and internal operations, enhancing productivity and efficiency [34][35] - The newborn screening market has shown growth due to geographic expansion and the introduction of new assays, with partnerships driving further opportunities [46][48] Q&A Session Summary Question: Can you discuss the impact of the government shutdown on the reagents business? - The reagents business, particularly from BioLegend, experienced a modest impact from the shutdown, but the pharma biotech sector has continued to perform well [5][8] Question: What are the expectations for the software business moving into 2026? - The software business is expected to continue performing well, with a focus on annualized portfolio value (APV) rather than just organic growth [27][28] Question: How does the company view the China diagnostics market going forward? - The company anticipates that the China diagnostics market will stabilize, contributing around 5-6% to total revenue, with a focus on localizing operations and obtaining faster approvals [43][44]

Financial Data and Key Metrics Changes - The company achieved revenue of $699 million in Q3 2025, resulting in 1% organic growth, with foreign exchange (FX) providing a modest 1% tailwind [24][25] - Adjusted operating margins were 26.1%, slightly above expectations but down 220 basis points year-over-year due to tariffs, FX, and lower volume leverage [25][26] - Adjusted earnings per share (EPS) for the quarter was $1.18, exceeding the midpoint of guidance by $0.05 [6][26] - Free cash flow generated in the quarter was $120 million, representing approximately 90% of adjusted net income [7][8] Business Line Data and Key Metrics Changes - The Signals software business grew 20% organically in the quarter, with strong performance in Software as a Service (SaaS) [5][29] - The reproductive health business grew in the mid-single digits year-over-year, with newborn screening growing in the high single digits [5][31] - The diagnostics segment generated $356 million in revenue, up 3% on a reported basis and 2% organically, with immunodiagnostics declining in the low single digits [29][30] Market Data and Key Metrics Changes - The Americas saw low single-digit growth, Europe experienced mid-single-digit growth, while Asia declined in the mid-single digits, with China down in the low teens [28] - The life sciences segment generated revenue of $343 million, up 1% on a reported basis and roughly flat on an organic basis [28] Company Strategy and Development Direction - The company is focused on disciplined capital deployment, with a new $1 billion share repurchase authorization to replace the existing program [9] - The company is optimistic about future performance, anticipating organic growth of 2% to 4% for the year and adjusted EPS guidance raised to $4.90 to $5.00 [10][33] - The company is actively pursuing AI-driven solutions and strategic partnerships to enhance its product offerings and market position [12][14] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about improving customer confidence and investment levels in the science sector, despite a stable demand environment [5][19] - The company is cautious in its assumptions until sustained improvements in broader industry demand trends are observed [10][19] - Management highlighted the importance of recent strategic partnerships, including collaborations with Genomics England and Sanofi, which are expected to drive future growth [16][17] Other Important Information - The company reported a 6% reduction in Scope 1 and 2 emissions in 2024 and a 77% employee satisfaction rate [18][19] - The company received a AAA rating from MSCI, indicating strong performance in environmental, social, and governance (ESG) criteria [19] Q&A Session Summary Question: Commentary on 2026 growth outlook - Management indicated a prudent assumption of 2% to 3% organic growth for 2026, with signs of increasing activity in the pharma and biotech sectors [36][37] Question: Insights on life sciences business performance - Management noted that reagents were modestly lower than anticipated, with expectations for a similar market environment moving forward [41][42] Question: Customer activity levels in October - Management observed increasing activity primarily from pharma and biotech customers, particularly in instruments [45][46] Question: EPS growth expectations for 2026 - Management indicated that a 2% to 3% organic growth rate with 28% operating margins would imply high single-digit EPS growth for 2026 [47][48] Question: Confidence in Q4 ramp - Management expressed confidence in the ramp from Q3 to Q4, citing seasonal increases and expected contributions from software and instruments [53][55] Question: China diagnostics outlook - Management confirmed that China diagnostics would continue to face headwinds, with expectations for a return to muted growth levels in the second half of 2026 [76][78]