Core Viewpoint - Obesity is a significant health risk that can lead to various chronic diseases, and it is essential to understand its complex nature beyond simple lifestyle choices [4][6][21]. Group 1: Understanding Obesity - Obesity is often misperceived as merely a result of personal behavior, but it is influenced by societal changes and has become a major health issue in China, which has the fastest-growing obesity rates globally [4][6]. - The World Health Organization defines obesity with a BMI threshold of ≥30.0 kg/m², while Chinese guidelines set it at ≥28 kg/m², indicating a need for tailored approaches to obesity diagnosis and management [7][21]. - Obesity is not a singular disease but a complex health issue with various classifications based on genetic, metabolic, and environmental factors, necessitating comprehensive evaluation for effective treatment [7][21]. Group 2: Health Risks Associated with Obesity - Obesity significantly increases the risk of developing type 2 diabetes, hypertension, sleep apnea, and can reduce life expectancy by 6 to 14 years [6][21]. - The relationship between obesity and psychological issues, such as anxiety and depression, is critical, as these can exacerbate unhealthy behaviors leading to further weight gain [19][21]. Group 3: Specific Conditions Related to Obesity - Conditions like hypothyroidism, Cushing's syndrome, and polycystic ovary syndrome (PCOS) are linked to obesity, with specific symptoms and metabolic disruptions that require targeted management [8][10][12]. - Genetic factors play a role in obesity, with certain rare genetic syndromes leading to early-onset obesity and associated metabolic disorders, highlighting the need for genetic screening in specific populations [13][15][16]. Group 4: Treatment and Management Strategies - Effective obesity management requires a multifaceted approach, including lifestyle changes, psychological support, and medical interventions tailored to individual needs [21]. - Identifying and addressing medication-induced weight gain is crucial, as certain drugs can significantly contribute to obesity [18][21].