以下文章来源于肥胖世界ObesityWorld ，作者肥胖世界 肥胖世界ObesityWorld . 肥胖的危害众所周知，而减重能直接逆转肥胖引发的代谢紊乱和心血管疾病。虽然减重最直接影响的是脂肪组织，但令人惊讶的是，科学界对 减重前后脂肪组织的微观变化知之甚少。 这一认知盲区源于两大挑战：首先，脂肪组织结构极其复杂，除脂肪细胞外，还包含免疫细胞、血管系统和基质细胞，它们杂乱无章地混合在 一起，不像其他器官那样井然有序；其次，脂肪细胞体积庞大，常常遮挡邻近细胞，使得获取精确的单细胞分辨率测序数据异常困难。 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 近日，《自然》杂志刊发了一项突破性研究，来自伦敦帝国理工学院的科学家们分析了70名受试者的惊人17万余个细胞，首次构建了减肥手术 后人类脂肪组织的单核空间转录组图谱。 这项开创性研究揭示了一个令人振奋的发现：肥胖会加速细胞衰老，而减重能显著逆转这种衰老过程，表明脂肪组织功能的恢复可能是减肥带 来全身多器官代谢改善的核心机制。此外，减重能有效抑制促炎巨噬细胞 ...

以下文章来源于肥胖世界ObesityWorld ，作者肥胖世界 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 | https://doi.org/10.1038/s41586-025-09233-2 | Antonio M. A. Miranda12 Liam McAllan 12, Guianfranco Mazzei12, Ivan Andrew12, Iona Davies3, | | --- | --- | | Received: 31 May 2024 | Meryem Ertugrul12, Julia Kenkre34, Hiromi Kudo3, Joana Carrelha", Bhavik Patel22, | | | Sophie Newton12, Weihua Zhang88 , Alice Pollard', Amy Cross10, Oliver McCallion10, | | Accepted: 3 June 2025 | Mikv ...

Group 1 - Insulin resistance is a condition where the body's sensitivity to insulin decreases, leading to impaired glucose regulation and potential health issues [1][5][12] - Insulin plays a crucial role in managing blood sugar levels by facilitating the uptake of glucose into cells for energy [1][12] - Common methods to assess insulin resistance include measuring fasting insulin levels and conducting glucose clamp tests [1] Group 2 - Body Mass Index (BMI) is a widely used indicator for assessing body weight, with values of 24 or higher indicating overweight and 28 or higher indicating obesity [2][4] - Abdominal obesity is defined by waist circumference measurements of 90 cm or more for men and 85 cm or more for women [2][4] Group 3 - Genetic factors significantly influence the likelihood of developing insulin resistance, particularly in individuals with a family history of diabetes [5] - Age is another critical factor, as the risk of insulin resistance increases with age, although it can also occur in children and adolescents [5] Group 4 - Environmental and lifestyle factors contributing to insulin resistance include overweight and obesity, particularly central obesity, which affects insulin sensitivity [6][8] - Sedentary behavior and lack of physical activity reduce glucose utilization by muscle cells, further exacerbating insulin resistance [8] - Unhealthy dietary habits, such as high-energy diets rich in refined carbohydrates and sugars, can lead to increased insulin resistance [9] Group 5 - Insulin resistance is associated with several health risks, including the development of type 2 diabetes, obesity, cardiovascular diseases, and fatty liver disease [12][13][15][16] - The condition creates a vicious cycle where high insulin levels promote fat accumulation, which in turn worsens insulin sensitivity [13] Group 6 - Improving insulin resistance can be achieved through healthy dietary habits, such as reducing refined carbohydrate intake and increasing the consumption of whole grains and quality proteins [17][19] - Regular physical activity is essential, with recommendations of at least 150 minutes of moderate-intensity aerobic exercise per week, combined with strength training [19] - Medical intervention may be necessary for individuals showing prediabetic symptoms, emphasizing the importance of professional guidance [20]

Core Viewpoint - The article discusses the significant health risks associated with obesity, emphasizing that it is not merely an aesthetic issue but a precursor to various metabolic diseases. The research highlights the mechanisms of fat tissue remodeling during weight loss and its implications for metabolic health management [6][18]. Group 1: Fat Tissue Remodeling Overview - A comprehensive single-cell atlas of adipose tissue was constructed, analyzing 171,247 cells from 70 subjects, including 25 severely obese individuals. The study focused on subcutaneous abdominal fat, revealing abnormal immune cell aggregation and a decrease in mature adipocytes in obese individuals, which improved significantly after weight loss [8][10]. Group 2: Abnormal Activation of Macrophages - The proportion of macrophages in adipose tissue increased from 14% to 31% in obesity, particularly lipid-associated macrophages (LAMs). Weight loss reduced this proportion to 18%, with a decrease in inflammation-related gene expression, although some metabolic activation remained, indicating potential epigenetic memory [10][12]. Group 3: Adipocyte Renewal and Metabolic Adaptation - Eight types of mature adipocytes were identified, with "stress-type" and "fibrotic-type" cells increasing in obesity, while "lipid-synthesis-type" cells decreased. Weight loss effectively reduced the stress-type cells and restored lipid-synthesis-type cells, enhancing metabolic functions and insulin sensitivity [12][14]. Group 4: Reversal of Multi-Cellular "Stress" State - Various subtypes of adipose precursor cells (APCs) were identified, with an increase in "stress-type" APCs during obesity. Weight loss led to a reduction in these cells and downregulated hypoxia and anti-adipogenic signals, improving the overall adipose tissue environment [14][16]. Group 5: Weight Loss and Cellular Aging - Weight loss was shown to downregulate multiple cellular aging markers, reducing the aging characteristics in adipose, precursor, and vascular cells. The study indicated a shared network between stress and aging cells, which weight loss could effectively mitigate [16][18].

Core Viewpoint - The article emphasizes the severity of overweight and obesity issues in China, highlighting the need for effective weight management strategies in response to the "Healthy China 2030" initiative [1]. Group 1: Current Situation of Overweight and Obesity - Over half of the adult population in China is classified as overweight or obese, with a reported overweight rate of 34.3% and an obesity rate of 16.4% [4][5]. - The absolute number of overweight and obese individuals in China has surpassed 600 million, making it the highest in the world [5]. - Projections indicate that by 2030, the overweight and obesity rates among adults in China could rise to 65.3% [7]. Group 2: Understanding Obesity - Obesity is defined as a condition where body weight is significantly above normal, primarily due to excessive fat accumulation, particularly triglycerides [8]. - There are two types of obesity: simple obesity, which is not caused by organic diseases but influenced by genetics, social environment, psychological state, and lifestyle; and secondary obesity, which is linked to other health issues [9][10][11]. Group 3: Health Risks Associated with Obesity - Obesity is associated with numerous health risks, including hypertension, high blood sugar, high blood lipids, fatty liver, coronary heart disease, myocardial infarction, stroke, and certain cancers [17][19]. - Recent research indicates that obesity in youth significantly increases the risk of developing 17 different types of cancer later in life [19]. Group 4: Dietary Recommendations for Weight Management - A balanced diet is crucial for effective weight management, with recommendations to prioritize whole grains, fresh vegetables, and low-fat protein sources while limiting high-calorie foods [21][22]. - Specific food categories are suggested for consumption, including whole grains, a variety of vegetables, and lean proteins, while avoiding fried foods, sugary snacks, and high-fat meats [23][24]. Group 5: Tips for Sustainable Weight Loss - Emphasizing the importance of not making healthy eating feel like a punishment, the article suggests that sustainable weight loss comes from developing good habits and finding a balanced approach to nutrition [27][28]. - It is advised to monitor body measurements rather than just weight, as changes in body composition can occur without significant weight loss [29][30]. - Intermittent fasting is highlighted as an effective method for weight management, with recommendations to consult a professional for guidance [32].

Core Viewpoint - The article emphasizes the growing global challenge of obesity and its significant health implications, highlighting the urgent need for effective weight management strategies in response to the "Healthy China 2030" initiative [5]. Global Overweight and Obesity Status - By 2030, over 2.9 billion adults worldwide are projected to have a high BMI, with 1.1 billion classified as obese (BMI ≥ 30 kg/m²), including 487 million men and 643 million women [7]. - In China, the proportion of adults with high BMI (BMI ≥ 25 kg/m²) has been steadily increasing, expected to reach 41% by 2025, with an obesity prevalence of 9%. The estimated number of adults with high BMI in China by 2030 is projected to be 515 million [7]. Non-Communicable Diseases and High BMI - In 2021, over 17 million people under 70 died from non-communicable diseases, with 11 million of these deaths attributable to avoidable risk factors, where high BMI accounted for 15% of these preventable early deaths [9]. - The report highlights four major categories of non-communicable diseases linked to high BMI: diabetes, cardiovascular diseases, cancer, and chronic respiratory diseases, with high BMI significantly increasing the risk of these conditions [9]. Effective Control of Overweight/Obesity - The World Health Organization stresses that regular physical activity is crucial for preventing and controlling obesity, as well as reducing the risk of various diseases, including hypertension, multiple cancers, osteoporosis, type 2 diabetes, stroke, and heart disease [10]. - Despite the benefits, approximately one-third of adults and 81% of adolescents globally do not meet recommended physical activity levels, with sedentary behavior becoming increasingly common due to lifestyle changes [10]. - Unhealthy dietary factors, such as high sodium intake, insufficient whole grain consumption, excessive processed meat and sugary drink intake, and inadequate fruit and vegetable consumption, are closely linked to the risk of non-communicable diseases and premature death [10].

Core Viewpoint - Obesity is a chronic metabolic disease that poses significant health risks, including the development of various serious chronic diseases such as diabetes, coronary heart disease, and stroke. The perception of obesity as merely a personal behavior issue is misleading, as societal changes have contributed to a rapid increase in obesity rates in China, making it the country with the fastest-growing prevalence of overweight and obesity globally [3][4]. Summary by Sections Understanding Obesity - Obesity is not just a simple condition but a complex health issue with various classifications based on genetic, metabolic, and anatomical factors. The World Health Organization (WHO) defines obesity with a BMI threshold of ≥30.0 kg/m², while Chinese guidelines set it at ≥28 kg/m². This classification reflects the need for a nuanced understanding of obesity beyond mere weight [5][6]. Health Risks Associated with Obesity - Obesity significantly increases the risk of developing type 2 diabetes, hypertension, sleep apnea, and can lead to a reduction in life expectancy by 6 to 14 years. The healthy BMI range for adults is defined as 18.5-23.9 kg/m², and exceeding this range indicates potential health risks [4][5]. Types of Obesity - Obesity can be categorized into various types, including genetic obesity, acquired obesity, central obesity, and peripheral obesity. The modern classification emphasizes clinical practicality, distinguishing between metabolically healthy and unhealthy obesity, and recognizing the importance of identifying underlying pathological factors [5][6]. Specific Conditions Related to Obesity - **Hypothyroidism**: Often goes unnoticed due to its subtle symptoms, which include weight gain, fatigue, and cold intolerance. Early recognition is crucial for effective management [6]. - **Cushing's Syndrome**: Characterized by excessive cortisol levels, leading to central obesity and other systemic complications. Early identification of its clinical features is vital for timely treatment [9][10]. - **Polycystic Ovary Syndrome (PCOS)**: A prevalent endocrine disorder among women in China, with a high incidence of hyperandrogenism, leading to abdominal obesity and insulin resistance [11][12]. - **Genetic Obesity**: Rare but significant, often linked to specific genetic mutations affecting energy metabolism. Early diagnosis through genetic testing can guide treatment [12][14]. Contributing Factors to Obesity - **Medication-Induced Obesity**: Certain medications, including those for diabetes and psychiatric conditions, can lead to weight gain. Identifying these medications is essential for effective weight management [17]. - **Psychological Factors**: Increased anxiety and stress in modern society contribute to unhealthy eating behaviors and sedentary lifestyles, exacerbating obesity [18]. - **Gonadal Dysfunction**: Can lead to complex clinical presentations, including obesity, and requires careful evaluation for effective management [19]. Conclusion - Recognizing obesity as a chronic condition requiring long-term management is essential. Understanding the multifaceted causes of obesity can help in developing targeted interventions to prevent related complications and promote healthier lifestyles [20].

Core Viewpoint - The article emphasizes the increasing prevalence of obesity in China and the need for effective weight management strategies in line with the "Healthy China 2030" initiative. It highlights the importance of lifestyle changes over temporary dieting methods for sustainable weight loss. Group 1: Obesity Trends - The global obesity rate has surpassed that of underweight individuals, with China having the highest number of obese individuals, exceeding 89.6 million in 2016 [5][11] - Over 50% of adults in China are classified as obese, with nearly 20% of children and adolescents also affected [5][13] - The rise in obesity is attributed to various factors, including genetic predisposition, lifestyle habits, and societal changes that promote sedentary behavior and unhealthy eating [11][12] Group 2: Challenges in Weight Loss - Many popular weight loss methods, such as intermittent fasting, often lead to temporary results and can result in weight regain [6][20] - Psychological factors, such as emotional eating, complicate the weight loss journey, making it difficult for individuals to maintain their goals [12][19] - The article stresses that successful weight management requires a comprehensive approach that includes behavioral changes and medical intervention when necessary [18][21] Group 3: Recommended Strategies for Weight Management - A successful weight loss strategy should focus on lifestyle changes, including adequate sleep, regular self-monitoring of weight, and a balanced diet low in salt, oil, and sugar [22][23] - The article advocates for a balanced approach to diet, emphasizing the importance of consuming whole grains and high-fiber foods while avoiding refined sugars [25][27] - Regular physical activity is crucial, with recommendations for a mix of aerobic and strength training exercises to enhance weight loss and body composition [31][32]

Core Viewpoint - The article emphasizes the launch of a three-year "Weight Management Year" initiative by the National Health Commission to address the increasing issues of overweight and obesity in China, promoting scientific weight loss and healthy lifestyles [3][4]. Group 1: Current Situation of Overweight and Obesity - The report indicates that the overweight and obesity rates among Chinese youth aged 6-17 have reached 19%, while the adult population's rate stands at 50.7% [5]. - Over the past 15 years, the obesity rate among adolescents has surged by 12 times, with workplace-related obesity and elderly obesity becoming more prevalent [5]. - Chronic diseases related to obesity, such as hypertension, diabetes, and cardiovascular diseases, account for over 70% of the national disease burden, with direct medical expenses exceeding 240 billion yuan annually [5]. Group 2: Obesity Assessment Criteria - Obesity is primarily assessed using BMI and waist circumference metrics, with a normal BMI range defined as 18.5 to 23.9 [6]. - Waist circumference is a critical indicator of abdominal obesity, with men exceeding 90 cm and women exceeding 85 cm at risk [8]. - Other common obesity assessment indicators include body fat percentage and waist-to-hip ratio, with specific thresholds indicating obesity risk [9]. Group 3: Consequences of Obesity - Obesity is linked to increased body weight and is closely associated with blood sugar and lipid levels, leading to insulin resistance and elevated blood sugar, which can progress to diabetes [10]. - It is also a significant risk factor for dyslipidemia, with excess body fat leading to abnormal blood lipid levels [11]. - Regular monitoring of blood sugar and lipid levels is essential, even for individuals with a normal BMI, to ensure metabolic health [12]. Group 4: Multi-Dimensional Weight Management Strategies - Enhancing basal metabolic rate (BMR) through muscle gain and regular exercise is crucial for effective weight management [13]. - B vitamins play a vital role in energy metabolism, influencing both basal and activity metabolic rates, and their deficiency can lead to metabolic disorders [14]. - Reducing exposure to toxic elements and endocrine disruptors is important for maintaining metabolic balance and preventing obesity [15]. Group 5: Gut Health and Digestion - A healthy gut is essential for nutrient absorption and waste elimination, with gut microbiota playing a significant role in weight regulation [17]. - Hormonal balance, regulated by the endocrine system, is critical for metabolism and energy management, with disruptions potentially leading to obesity [17]. - A balanced diet, incorporating various nutrients, is fundamental for effective weight management and healthy weight loss [17].

Core Viewpoint - Obesity is a significant public health challenge globally, with approximately 40% of adults being overweight or obese. In China, over half of the adult population is affected, and nearly one-fifth of school-aged children are overweight. The article emphasizes the importance of scientific and healthy weight management strategies to combat obesity and its associated health risks [4]. Summary by Sections Weight Management Strategies - The article introduces the "20 Action Points for Weight Management" based on scientific evidence, focusing on dietary, exercise, and behavioral interventions [4]. Dietary Recommendations - A balanced diet primarily consisting of grains is recommended for healthy weight loss, with an emphasis on including grains, fruits, vegetables, and protein sources while reducing fats, salt, and sugar intake [5]. - Increasing dairy intake is beneficial for weight control, with studies indicating positive effects of milk on overweight, obesity, type 2 diabetes, and cardiovascular diseases. The recommended daily intake is 300-500 grams of liquid milk or equivalent dairy products [6][7]. - Avoiding late-night snacks and skipping breakfast is crucial, as these habits are linked to increased obesity risk. Eating breakfast stabilizes blood sugar and enhances insulin sensitivity, while late-night eating can negatively impact metabolism [8]. - Eating slowly is advised, with meals taking over 20 minutes to consume, as rapid eating is associated with obesity. Slower eating can reduce calorie intake and enhance feelings of fullness [8]. - The effectiveness of dietary supplements for weight loss is uncertain, and caution is advised in their use due to a lack of conclusive scientific evidence [9]. Exercise Recommendations - Various forms of exercise, including aerobic, resistance training, and high-intensity interval training, are effective for weight loss [10]. - A weekly total of over 250 minutes of moderate-intensity exercise is recommended for significant weight loss, with higher intensity yielding better results. The target heart rate for moderate exercise is 40%-60% of maximum heart rate [12]. Sleep and Stress Management - Quality sleep is essential for weight management, with a recommendation of at least 7 hours of sleep per night to prevent obesity, particularly abdominal fat accumulation [14]. - Managing psychological stress is also important, as chronic stress can increase obesity risk. Maintaining a positive mental state supports ideal weight maintenance [15].