Group 1 - The 15th Peking University Digestive Tumor Forum and the annual meeting of the China Gastrointestinal Oncology Clinical Research Collaborative Group (CGOG) were held in Beijing, focusing on precision diagnosis and translational research in digestive system tumors [1] - The theme of the conference was "Innovation, Precision, and Synergy," emphasizing the advancement of innovative diagnostic and treatment models as well as new drug development [1] - The Human Proteome Navigation Plan (π-HuB Plan) was introduced, aiming to uncover life-related information from the complexity and dynamics of the human proteome, with four main objectives outlined [1] Group 2 - Professor Shen Lin from Peking University Cancer Hospital proposed a "B to B" bidirectional translational research model to explore new treatment options targeting HER2, EGFR, and CLDN18.2 for upper digestive tract tumors [2] - The complexity of the tumor microenvironment necessitates a multidimensional exploration of tumor heterogeneity, precise selection of beneficiaries for targeted therapy, and enhanced efficacy monitoring [2] - The improvement of CAR-T therapy efficacy in solid tumors is identified as an urgent research topic, with a call for a comprehensive clinical-translational-basic bidirectional research system to promote clinical application of precision treatment for upper digestive tract tumors [2]