Core Insights - On May 28, 2025, a total of 23 papers were published in the prestigious journal Nature, with 13 authored by Chinese scholars, highlighting the significant contribution of Chinese researchers to global scientific advancements [1][3][5]. Group 1: Research Highlights - The research by Huang Xiaoqiang from Nanjing University focuses on electricity-driven enzymatic dynamic kinetic oxidation, achieving a breakthrough in the compatibility of traditional electrochemistry and enzyme catalysis, paving the way for asymmetric biosynthesis of phenylpropanoids like ibuprofen [1]. - Stephen Tang from Columbia University revealed a novel antiviral mechanism of the DRT9 reverse transcriptase family, demonstrating its role in synthesizing poly-dA to combat infections, thus expanding the understanding of bacterial immune systems [2]. - The study by professors Bao Xiaojun and Zhu Haibo from Fuzhou University, along with Ye Mao from the Dalian Institute of Chemical Physics, discusses platinum migration in zeolites for stable propane dehydrogenation catalysts, contributing to advancements in catalytic processes [3]. Group 2: Cancer Research - The research led by Academician Zhang Zemin from Peking University and Chongqing Medical University introduces the concept of "Cross-tissue Cellular Modules" (CM) and develops a computational framework (CoVarNet) to identify these modules, providing insights into multicellular coordination in cancer progression [4]. Group 3: Environmental Studies - A study by Zhang Liangpei and colleagues discusses the reduction of radiative forcing due to increased land albedo in the early 21st century, emphasizing the impact of land surface changes on climate dynamics [6]. - Research by Zheng Bo and Zhao Yuanhong examines how air pollution affects global methane budget trends and variability, highlighting the interplay between environmental factors and greenhouse gas emissions [7]. Group 4: Semiconductor Research - The work by Professor Pei Jian from Peking University presents a method for light-triggered regionally controlled n-doping of organic semiconductors, which could enhance the performance of electronic devices [8]. Group 5: Quantum Physics - The research by Guo Yanliang discusses the observation of anyonization of bosons in a quantum gas, contributing to the understanding of quantum states and their applications [9]. Group 6: Behavioral Science - The study by Andrew Wang from Yale University reveals that gut-derived T cells act as a communication link to the brain, influencing behavior through the subfornical organ, thus bridging immunology and neuroscience [11]. Group 7: Seasonal Dynamics - Research by Professor Long Di from Tsinghua University highlights the global dominance of seasonality in shaping lake-surface extent dynamics, providing insights into ecological changes driven by seasonal variations [12]. Group 8: Magnetism - The study by Qian Song from MIT explores the electrical switching of a p-wave magnet, which could have implications for future magnetic materials and technologies [13].

Core Viewpoint - The article discusses a groundbreaking study published in Nature by a team led by Academician Zhang Zemin, focusing on the concept of "cross-tissue cellular modules" and their role in multicellular coordination within human tissues, particularly in the context of cancer progression [2][16]. Group 1: Research Background - The study integrates single-cell transcriptomic data from 706 healthy samples across 35 human tissues, creating the most comprehensive cross-tissue single-cell atlas to date, covering 2.29 million cells [8][16]. - The research identifies significant differences in cellular composition across various healthy tissues, revealing 12 distinct cross-tissue cellular modules (CMs) with unique cellular compositions and distributions [9][16]. Group 2: Cellular Modules and Their Functions - The identified cellular modules include CM04, CM05, CM06, and CM09, which are abundant in primary and secondary immune organs, indicating their roles in immune cell production and maturation [10][13]. - Other modules, such as CM02 and CM03, are primarily found in the urinary system and gastrointestinal tract, while CM08 is enriched in barrier tissues like skin and mucosal surfaces, suggesting their specific functional roles [10][11]. Group 3: Spatial Dynamics and Aging - The study employs spatial transcriptomics to illustrate how these cellular modules are spatially organized within tissues, highlighting their functional roles in maintaining tissue homeostasis [14][16]. - Notably, the immune cell modules CM05 and CM06 exhibit contrasting temporal dynamics with aging, where CM05 increases while CM06 decreases, indicating their potential as biomarkers for age-related changes [14][16]. Group 4: Implications for Cancer Research - The research extends to the tumor microenvironment (TME), analyzing single-cell transcriptomic data from 1,062 clinical samples across 29 cancer types, identifying 91 cell subpopulations [15][16]. - It reveals a dual remodeling of cellular modules during tumor progression, where healthy tissue-specific modules are lost, and cancer-associated modules emerge, providing insights into the fundamental organizational principles of multicellular ecosystems in health and disease [15][16].