智通财经APP获悉，周三，阿斯利康(AZN.US)涨逾2%，报81.99美元。高盛近日发布研报称，阿斯利康 此前在2025欧洲心脏病学会(ESC)年会上公布了Baxdrostat在BaxHTN III期临床试验中取得积极结果。 Baxdrostat在临床试验中展现出了在治疗高血压方面的强劲效果，有望给阿斯利康带来数十亿美元的销 售机会。高盛予阿斯利康"买入"评级，12个月目标价为99美元。这一目标价较该股周二收盘价80.19美 元有约23%的上涨空间。 资料显示，Baxdrostat是一种高选择性的醛固酮合成酶抑制剂(ASI)，靶向作用于导致血压升高及心血管 和肾脏风险增加的激素之一。目前，该药正在全球范围内开展临床试验，累计入组患者超过20,000人， 试验包括作为单药疗法治疗高血压和原发性醛固酮增多症，及与达格列净联用治疗慢性肾脏病和高血 压，以及高血压患者预防心力衰竭。据悉，Baxdrostat有望于2026年上半年率先在美欧获批，成为全球 首个上市的醛固酮合成酶抑制剂(ASI)降压药。 ...

高盛在研报中表示，Baxdrostat的BaxHTN III期试验数据对阿斯利康构成明显利好，其疗效符合该行此 前预期。该行补充称，基于与行业人士的交流，Baxdrostat的疗效很可能引发医生群体的显著兴趣。 智通财经APP获悉，高盛近日发布研报称，阿斯利康(AZN.US)此前在2025欧洲心脏病学会(ESC)年会上 公布了Baxdrostat在BaxHTN III期临床试验中取得积极结果。Baxdrostat在临床试验中展现出了在治疗高 血压方面的强劲效果，有望给阿斯利康带来数十亿美元的销售机会。高盛予阿斯利康"买入"评级，12个 月目标价为99美元。这一目标价较该股周二收盘价80.19美元有约23%的上涨空间。 高盛提到了制药公司Mineralys Therapeutics也在研发的降压药Lorundrostat。该行指出，相比Lorundrostat 在Launch-HTN试验中的数据，Baxdrostat在平均坐位收缩压较基线降幅方面的数据稍逊一筹。数据显 示，在治疗第12周时，Baxdrostat 2毫克剂量组平均坐位收缩压较基线经安慰剂校正后的降幅为 9.8mmHg(p<0.001)。而在治疗第 ...

Core Viewpoint - The article emphasizes the long-term journey of innovation in the pharmaceutical industry, particularly in the hypertension treatment sector, highlighting the recent advancements and unmet needs in this area [3][4]. Group 1: Hypertension Overview - Hypertension affects approximately 1 billion people globally and has seen no significant breakthroughs in core treatment targets for over 40 years [4][5]. - It is a leading cause of cardiovascular diseases and overall mortality, with 10.8 million deaths attributed to high systolic blood pressure in 2019, accounting for about 20% of total deaths [6]. - The prevalence of hypertension is approximately 1.4 billion globally, with 80 million in the U.S. and 90 million in the EU, representing 31% and 24% of the adult population, respectively [6]. Group 2: Treatment Landscape - Current hypertension treatments include lifestyle changes, antihypertensive medications, and some devices [21]. - The article outlines the classification of hypertension into controlled and uncontrolled categories based on blood pressure readings and medication regimens [14]. - The recommended initial medications for hypertension treatment include ACE inhibitors, ARBs, thiazide diuretics, and calcium channel blockers [23]. Group 3: Recent Developments - The recent success of Mineralys in advancing hypertension treatment through innovative drug mechanisms has opened new possibilities in the field [4][5]. - The article discusses the concept of "aldosterone escape," where patients experience a rebound increase in aldosterone levels despite treatment, leading to resistant hypertension [36][39]. - Aldosterone synthase inhibitors (ASI) are highlighted as a promising new class of drugs that can directly inhibit aldosterone production, addressing both RAAS and non-RAAS pathways [40][42]. Group 4: Mechanisms of Hypertension - The pathophysiology of hypertension involves multiple systems, including renal, vascular, neural, and the RAAS system, with obesity also playing a significant role [26][27]. - The article explains the mechanisms by which aldosterone contributes to hypertension, including both direct and indirect pathways [29][36]. Group 5: Clinical Implications - The article emphasizes the importance of accurate blood pressure measurement techniques to avoid misdiagnosis of hypertension, such as white coat hypertension and masked hypertension [18][20]. - It also discusses the need for personalized treatment goals based on individual patient circumstances, particularly for older adults or those with multiple comorbidities [20].