Group 1 - The research conducted by Professor Yu Jun's team at the Chinese University of Hong Kong demonstrates that Pien Tze Huang may be an effective drug for the prevention and treatment of non-alcoholic steatohepatitis (NASH) [1] - Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population, with a prevalence of 34% in Asian populations, and about 20% of NAFLD patients progress to NASH [2] - The study indicates that Pien Tze Huang effectively prevents the progression of NASH induced by various diets, significantly inhibiting liver damage, triglyceride accumulation, and lipid peroxidation [2] Group 2 - The incidence of fatty liver disease in China has been rising, with adult prevalence reaching 12.5% to 35.4%, indicating that one in three adults may suffer from fatty liver [3] - The research by Professor Yu Jun's team provides a new approach for the prevention and treatment of the leading liver disease in China [3] - The company has been actively exploring the secondary development of Pien Tze Huang and related products, with 11 clinical research projects and 23 pharmacological studies initiated in 2024 [3]

Core Insights - The research conducted by Professor Yu Jun's team at the Chinese University of Hong Kong focuses on the effects of Pien Tze Huang in preventing and treating non-alcoholic steatohepatitis (NASH) through modulation of gut microbiota and metabolites in mice [1][3] Group 1: Health Issue Overview - Non-alcoholic fatty liver disease (NAFLD) is a significant global health issue, affecting 25% of the world's population, with an even higher prevalence of 34% in Asian populations [3] - Approximately 20% of NAFLD patients may progress to more severe NASH, for which there are currently no effective treatments [3] Group 2: Traditional Medicine Focus - Traditional Chinese medicine, particularly Pien Tze Huang, is gaining attention due to its multi-target and multi-pathway mechanisms, with key ingredients including Panax notoginseng, musk, bezoar, and snake bile [3] Group 3: Research Findings - The study evaluates the role of Pien Tze Huang in the prevention and treatment of NASH, elucidating its effects on gut microbiota distribution and gut barrier function improvement in NASH models [3] - Metagenomic sequencing of mouse fecal samples revealed that Pien Tze Huang can restore gut microbiota imbalance and improve gut barrier function in mice with fatty liver disease [3] - The results indicate that Pien Tze Huang effectively prevents the progression of NASH induced by high-fat and high-cholesterol diets, significantly inhibiting liver damage, triglyceride accumulation, and lipid peroxidation [3] - Additionally, Pien Tze Huang significantly improves fatty degeneration and liver damage in mice [3]