Core Viewpoint - The article discusses the discovery of Lac-Phe, a metabolite produced during intense exercise, which suppresses appetite and aids in weight loss without adverse side effects [2][3][10]. Group 1: Research Findings - Lac-Phe is identified as the most significantly increased metabolite in the blood after intense exercise, observed in mice, humans, and racehorses [6]. - The recent study published in Nature Metabolism reveals that Lac-Phe inhibits AgRP neurons, which are responsible for stimulating hunger, thereby reducing food intake [3][10]. - The mechanism by which Lac-Phe suppresses appetite involves the activation of ATP-sensitive potassium channels (K ATP) on AgRP neurons, leading to hyperpolarization and reduced activity of these neurons [11]. Group 2: Implications for Weight Management - The findings provide insights into how exercise naturally lowers appetite and improves metabolism, suggesting potential new targets for obesity treatment [12]. - The research indicates that both metformin and exercise may utilize the same pathway through Lac-Phe to achieve appetite suppression and weight loss [8].