BOSTON, Dec. 17, 2025 (GLOBE NEWSWIRE) -- Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics, today announced that the Company will present at the J.P. Morgan 2026 Healthcare Conference on January 14, 2026. Presentation DetailsDate: Wednesday, January 14, 2026 Time: 7:30 AM PT Webcast Link: cmpx.info/jpmorgan Virtual/Replay availability: The presentation will be archived on Compass’ Events page. Investors ...

Core Viewpoint - Compass Therapeutics, Inc. is actively engaging with investors through participation in key healthcare conferences in December 2025, highlighting its focus on oncology and proprietary antibody-based therapeutics [1][2]. Group 1: Upcoming Investor Events - Compass Therapeutics will participate in the Piper Sandler 37th Annual Healthcare Conference on December 2, 2025, at 8:00 AM ET in New York, NY [2]. - The company will also attend the 8th Annual Evercore Healthcare Conference on December 4, 2025, at 10:00 AM ET in Coral Gables, FL [2]. - Presentations from these events will be archived for 90 days on Compass' Events page, allowing for virtual/replay availability [2]. Group 2: Company Overview - Compass Therapeutics is a clinical-stage biopharmaceutical company focused on developing proprietary antibody-based therapeutics for oncology [4]. - The company’s research emphasizes the interplay between angiogenesis, the immune system, and tumor growth, aiming to create a robust pipeline of novel product candidates [4]. - The therapeutic strategies include targeting angiogenesis, inducing immune responses, and overcoming immunosuppressive mechanisms utilized by tumors [4]. - Founded in 2014, Compass Therapeutics is headquartered in Boston, Massachusetts [4].

Core Viewpoint - Compass Therapeutics Inc. (NASDAQ:CMPX) is viewed positively by analysts due to significant advancements in its clinical pipeline, with price targets set at $12 and $24 by different analysts [1][2]. Company Developments - The company has made notable progress in its drug pipeline, particularly with the development of CTX-10726, a tetravalent antibody aimed at inhibiting tumor angiogenesis [2]. - During the third-quarter 2025 results, the CEO highlighted lower mortality rates in a randomized trial of tovecimig for patients with advanced biliary tract cancer (BTC) and anticipates delivering overall survival (OS) and progression-free survival (PFS) data in the first quarter of the next year [3]. - The company expects to support its first Biologics License Application (BLA) filing in the second half of 2026, based on secondary endpoint data that builds on previously reported primary endpoint results [4]. Market Potential - Recent market research indicates approximately 25,000 new BTC diagnoses annually in the United States, suggesting a significant market opportunity for tovecimig, especially for patients lacking approved therapeutic options [4]. Financial Performance - The company reported a net loss of $14.3 million, or $0.08 per share, which is an increase from a net loss of $10.5 million in the same quarter the previous year. This wider loss is attributed to increased research and development expenses, which rose to $12.8 million from $8.6 million year-over-year [5]. Company Overview - Compass Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing proprietary antibody-based therapies for cancer, emphasizing the interplay between angiogenesis, the immune system, and tumor growth [6].

Summary of Tectonic Therapeutics FY Conference Call Company Overview - **Company**: Tectonic Therapeutics (NasdaqGM: TECX) - **Focus**: Development of novel therapeutics targeting heart failure and pulmonary hypertension Key Molecule: TX-45 - **Description**: TX-45 is a long-acting relaxin mimetic with potential applications in heart failure and pulmonary hypertension [3][4] - **Mechanisms of Action**: - Acts as a vasodilator for both peripheral and pulmonary circulation [4] - Functions as a leisotropic agent, relaxing heart muscle during diastole [4] - Exhibits antifibrotic properties by increasing metalloproteinases and inhibiting the TGF beta pathway [5] Target Patient Population - **Heart Failure with Preserved Ejection Fraction (HFpEF)**: Estimated 3.5 to 4 million patients in the U.S. [9] - **Specific Subset**: Approximately 1.4 million patients with Class II and III heart failure and elevated pulmonary pressures, with around 700,000 to 1 million having combined pre- and post-capillary pulmonary hypertension (CPCPH) [10] Competitive Landscape - **Lilly's Program**: Competes with a long-acting relaxin designed differently, leading to fluid retention issues in decompensated heart failure patients [12][13] - **AstraZeneca**: Conducting studies in similar patient populations, focusing on pulmonary vascular resistance [24] - **Merck**: Investigating treatments for pulmonary hypertension, with potential data release expected [29] Clinical Trial Updates - **Phase Ib Study**: Showed a 32% to 35% reduction in pulmonary vascular resistance and an 18% to 19% reduction in pulmonary capillary wedge pressure [38] - **Phase II APeX Trial**: Over 30% enrollment, focusing on patients with high pulmonary vascular resistance [42] - **Future Trials**: Plans to initiate a trial for pulmonary hypertension associated with interstitial lung disease (PHILD) in 2026 [50] Additional Program: Hereditary Hemorrhagic Telangiectasia (HHT) - **Target Population**: 70,000 to 75,000 patients in the U.S., focusing on moderate to severe cases with no approved therapies [61] - **Study Timeline**: Phase I study expected to start in Q1 2026 [62] Platform Technology - **G Protein-Coupled Receptors (GPCRs)**: Tectonic's platform enables the development of antibodies against GPCRs, a significant target for drug development [66] Upcoming Milestones - **Data Releases**: Anticipated data from reduced ejection fraction Phase Ib study in October and further updates on clinical trials throughout 2026 [71][72] Conclusion - Tectonic Therapeutics is positioned to address significant unmet needs in heart failure and pulmonary hypertension with innovative therapies and a robust pipeline, while navigating a competitive landscape with ongoing clinical trials and strategic patient targeting.

Group 1 - Compass Therapeutics, Inc. announced a public offering of 33,290,000 shares of common stock priced at $3.00 per share, along with pre-funded warrants for 6,710,000 shares priced at $2.9999 each, expecting gross proceeds of approximately $120 million [1][2] - The offering is expected to close on or about August 14, 2025, subject to customary closing conditions, with underwriters granted a 30-day option to purchase an additional 6,000,000 shares [1][2] - The net proceeds will be used for commercial readiness preparations, funding research and clinical development of product candidates, and general corporate purposes [2] Group 2 - Jefferies, Piper Sandler, and Guggenheim Securities are acting as joint active bookrunning managers for the offering, with additional firms serving as lead and co-managers [3] - A shelf registration statement for the securities was filed with the SEC on August 30, 2024, and declared effective on September 6, 2024, with a preliminary prospectus supplement already filed [4] Group 3 - Compass Therapeutics is a clinical-stage biopharmaceutical company focused on oncology, developing proprietary antibody-based therapeutics targeting multiple diseases [6] - The company’s scientific focus includes the relationship between angiogenesis, the immune system, and tumor growth, with a robust pipeline of product candidates designed to target critical biological pathways for effective anti-tumor responses [6]

Company Overview - Compass Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on oncology, developing proprietary antibody-based therapeutics to treat various human diseases [3] - The company emphasizes the relationship between angiogenesis, the immune system, and tumor growth, aiming to create a robust pipeline of novel product candidates [3] - Founded in 2014 and headquartered in Boston, Massachusetts, Compass Therapeutics is advancing its product candidates through clinical development as standalone therapies and in combination with other proprietary antibodies [3] Upcoming Financial Results and Updates - Compass Therapeutics will release its financial results for the quarter ended June 30, 2025, and provide updates on the ongoing tovecimig Phase 2/3 study, clinical data for CTX-8371, and preclinical data for CTX-10726 on August 11, 2025, at 8:00 AM ET [1] - A webcast and conference call will be held to discuss these updates, with a replay available for 90 days on the company's Events page [2]