WATERTOWN, Mass., June 30, 2025 (GLOBE NEWSWIRE) -- Tectonic Therapeutic, Inc. (NASDAQ: TECX) ("Tectonic"), a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein coupled receptors (GPCRs), today announced that it has been added to the broad-market Russell 3000 Index. Tectonic's addition follows the conclusion of the 2025 Russell US Indexes annual reconstitution and is effective after the open of US equit ...

Core Insights - Tectonic Therapeutic, Inc. announced complete results from Part A of the Phase 1b clinical trial of TX45 for patients with Group 2 Pulmonary Hypertension in Heart Failure with preserved Ejection Fraction (PH-HFpEF) [1][2] - The trial demonstrated that TX45 is well tolerated and showed significant hemodynamic improvements, including a 19.0% reduction in pulmonary capillary wedge pressure (PCWP) and over 30% reduction in pulmonary vascular resistance (PVR) in a specific patient subgroup [2][11] - The results were presented at the European Society of Cardiology Heart Failure 2025 Congress, highlighting the potential of TX45 as a best-in-class therapy for a condition with high morbidity and no approved treatments [3][4] Clinical Trial Results - The Phase 1b trial included a cohort of 19 patients, confirming the tolerability and hemodynamic effects of TX45 previously reported in interim data [2][6] - TX45 treatment resulted in sustained hemodynamic effects for up to 29 days, with improvements in left ventricular function and pulmonary hemodynamics across various left ventricular ejection fractions (LVEF) [4][5] - Specific improvements included a 19.7% reduction in PCWP for patients with LVEF≥50% and an 18.4% reduction for those with LVEF 41-49% [5] Safety Profile - TX45 was well tolerated with no serious or severe adverse events reported during the trial [7][11] - There were no clinically significant changes in vital signs or safety laboratory values, indicating a favorable safety profile for TX45 [11] Mechanism of Action - TX45 is a long-acting Fc-relaxin fusion protein that activates the RXFP1 receptor, providing both pulmonary and systemic vasodilatory effects [13] - The differentiated mechanism of TX45 improves both left ventricular function and pulmonary hemodynamics, particularly beneficial for patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) [11][12] Future Outlook - The topline data from Part B of the Phase 1b study, which will evaluate TX45 in patients with Heart Failure with reduced Ejection Fraction (HFrEF), is expected in the second half of 2025 [3][9] - The ongoing APEX Phase 2 clinical trial is anticipated to provide further insights into the efficacy of TX45 in PH-HFpEF, with topline results expected in 2026 [2][9]

Tectonic Therapeutic (TECX) 2025 Conference May 15, 2025 12:20 PM ET Speaker0 Hey, everyone. Good morning, and welcome to day three of the twenty twenty five Bank of America Healthcare Conference. And thanks for joining this session with Tectonic Therapeutics. My name is Alex Stranahan. I'm senior biotech analyst at Bank of America. And I'm pleased to introduce Elise Raisin, president and CEO of Tectonic. She'll be running through some slides and going over the company. So with that, Elise, over to you. Spe ...

Tectonic Therapeutic, Inc. (TECX) closed the last trading session at $20.71, gaining 15.9% over the past four weeks, but there could be plenty of upside left in the stock if short-term price targets set by Wall Street analysts are any guide. The mean price target of $74.25 indicates a 258.5% upside potential.The mean estimate comprises four short-term price targets with a standard deviation of $20.71. While the lowest estimate of $51 indicates a 146.3% increase from the current price level, the most optimis ...

Financial Performance - Net loss for Q1 2025 was $15,906 thousand, a 5% increase from the net loss of $15,221 thousand in Q1 2024[108] - Cash used in operating activities was $13.1 million for the three months ended March 31, 2025, compared to $9.3 million in the same period of 2024[115] - As of March 31, 2025, the company had $306.2 million in cash and cash equivalents and an accumulated deficit of $164.5 million[114] Expenses - Research and development expenses increased by 21% from $10,818 thousand in Q1 2024 to $13,036 thousand in Q1 2025[108] - General and administrative expenses surged by 145% from $2,150 thousand in Q1 2024 to $5,262 thousand in Q1 2025[108] - Total operating expenses rose by 41% from $12,968 thousand in Q1 2024 to $18,298 thousand in Q1 2025[108] - Total research and development expenses increased by $2.2 million (21%) to $13.0 million for the three months ended March 31, 2025, compared to $10.8 million in the same period of 2024[110] - General and administrative expenses rose by $3.1 million (145%) to $5.3 million for the three months ended March 31, 2025, compared to $2.2 million in the same period of 2024[111] - The company expects to incur significant expenses and operating losses as it advances preclinical and clinical development, necessitating additional capital[113] - The company anticipates additional costs associated with operating as a public company and ongoing research and development activities[123] Revenue Generation - The company has not generated any revenue since inception and does not expect to do so in the foreseeable future[97] - The company has no approved products and has never generated revenue from product sales, relying on funding from various sources[114] Financing Activities - A private placement in February 2025 raised approximately $185.0 million by issuing 3,689,465 shares of common stock[94][95] - Net cash provided by financing activities was $178.1 million for the three months ended March 31, 2025, primarily from the sale of shares in a Private Placement[119] - Interest income increased significantly by 855%, from $256 thousand in Q1 2024 to $2,444 thousand in Q1 2025[108] - Interest income increased by $2.2 million for the three months ended March 31, 2025, primarily due to an increase in cash and cash equivalents following the Merger and Private Placement[112] Clinical Trials and Development - TX45 is currently in a Phase 1b hemodynamic clinical trial, with 19 patients dosed and preliminary data showing improvements in hemodynamics[92] - TX2100 is expected to enter a Phase 1 clinical trial in Q4 2025 or Q1 2026, pending results from IND enabling studies[93] Mergers and Acquisitions - A merger with AVROBIO was completed on June 20, 2024, enhancing the company's operational capabilities[96] Lease Obligations - Minimum lease payments due as of March 31, 2025, are $2.2 million in 2025, $0.5 million in 2026, and $0.1 million in 2027[127]

Exhibit 99.1 • Full Data from Phase 1b Part A Trial to be Presented at the ESC Congress: Full results from the TX45 Phase 1b trial in the Group 2 PH-HFpEF cohort will be presented as an oral late-breaking presentation at the European Society of Cardiology (ESC) Heart Failure 2025 Congress. The data set includes a total of 19 patients with PH-HFpEF. The presentation is scheduled for May 17, 2025, at 10:40 a.m. ET. • Ongoing Phase 1b Part B Results Expected 2H 2025: Part B of the TX45 Phase 1b hemodynamic cli ...

Interim analysis from the TX45 Phase 1b Part A trial demonstrated meaningful improvements in both left ventricular function and pulmonary hemodynamics in patients with Group 2 Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction (“PH-HFpEF”)Full results from the Phase 1b Part A trial will be presented on May 17, 2025 at the European Society of Cardiology (ESC) Heart Failure Congress in Belgrade, SerbiaPart B of the TX45 Phase 1b trial initiated in March with topline results expected in t ...

The live webcast can also be accessed under "Events & Presentations" on the Investors section of the Tectonic website at www.tectonictx.com. Once the conference has concluded, a replay of the webcast will be available on the Company's website for approximately 90 days. WATERTOWN, Mass., May 07, 2025 (GLOBE NEWSWIRE) -- Tectonic Therapeutic, Inc. (NASDAQ: TECX) ("Tectonic"), a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate th ...

WATERTOWN, Mass., April 15, 2025 (GLOBE NEWSWIRE) -- Tectonic Therapeutic, Inc. (NASDAQ:TECX) ("Tectonic"), a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein coupled receptors ("GPCRs"), today announced that it will make a late-breaking oral presentation at the European Society of Cardiology (ESC) Heart Failure 2025 Congress. The presentation will highlight Phase 1b data for TX45, Tectonic's lead ass ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _________________ to _________________ Commission File Number: 001-38537 TECTONIC THERAPEUTIC, INC. (Exact name of Registrant as specified in its Charter) Delaware ...