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Menopause and Estrogen's Impact - The decline of estrogen during perimenopause and menopause disrupts immune homeostasis, affecting the brain and emotions [3][7] - Estrogen receptors are located throughout the body, and their decline increases inflammatory cytokines, disrupting immune homeostasis and impacting neurotransmitter balance [7][8] - Decreased estrogen impacts BDNF (brain-derived neurotropic factor), affecting the brain's ability to grow, adapt, and recover, and also influences the hippocampus, impacting emotion and memory [8][9] - Biological disruptions during menopause can manifest as anxiety, depression, and cognitive brain fog [10] Resilience and Adaptation - Resilience is defined as the capacity to adapt and remain functional during biological shifts, and is crucial during menopause [13] - Estrogen modulates brain networks responsible for stress response, cognition, and emotional regulation [15] - Resilience is dynamic and depends on neuromimmune regulation and psychological adaptation [17] - Psychological adaptation is not adequately addressed in menopause treatment, despite the effectiveness of hormone therapy [18] Emotional Intelligence and Research - Cultivating emotional intelligence and capacity can help women adapt and thrive during menopause [20] - Emotional capacity and resilience include emotional stability, regulation, optimism, self-compassion, and self-trust [20] - The scientific community should quantify resilience, utilizing validated psychological questionnaires to assess women's well-being during perimenopause [22] - Combining neuroimmunology with the psychology of adaptation and resilience can redefine menopause, framing it as a dynamic period of growth [24]