Core Message - The "gap," representing challenging or unexpected situations, is presented as a valuable opportunity for growth and development, not just a setback [5][9][18] - Embracing the gap leads to the development of grit, the formation of alliances, and the gaining of perspective, all crucial for success [10][12][15] Entrepreneurial Insights - Success in entrepreneurship requires more than just endurance; it necessitates a mindset shift to recognize the value within challenging situations [9] - Entrepreneurs are often hesitant to seek help, but the "gap" highlights the necessity of collaboration and building a strong network of allies [13] - Teams that embrace clarity and flexible decision-making outperform their peers by 30% [16] Failure and Growth - Failure is an inherent part of the "gap," and the way it is perceived determines future success; it can be either a finality or fuel for growth [19][20] - Startups often fail due to gaps in leadership, collaboration, and perspective, rather than product flaws; CB Insights indicates a 70% failure rate [17] Personal Development - The "gap" is a universal experience, not limited to entrepreneurs, and can manifest in various forms, such as professional setbacks or personal challenges [19] - Embracing the "gap" and allowing it to shape one's path is essential for personal growth and achieving one's potential [23][24]

Having breast cancer in your 20s or 30s brings a unique set of considerations – and agonies https://t.co/YTe9TFFMDH ...

Hormone Replacement Therapy (HRT) Safety and Efficacy - The FDA Commissioner suggests removing black box warnings from HRT products, arguing they have unnecessarily deterred women from using these treatments [1][12] - A 2002 study led to a nearly 50% reduction in HRT use due to concerns about increased risks of heart disease and breast cancer [2] - Subsequent clinical trials have not confirmed that HRT increases breast cancer mortality, and cardiovascular complications are linked to starting HRT more than 10 years after menopause onset [4] - Starting HRT within 10 years of menopause onset can reduce heart disease risk by 30-50% and heart attack deaths by 48% [5] Benefits of HRT - HRT can alleviate menopause symptoms, which 80% of women experience, including hot flashes, night sweats, mood swings, and weight gain [6][7] - Long-term benefits of HRT include reducing cognitive decline by up to 64% and Alzheimer's risk by 35% in some studies, as well as reducing bone fracture rates [7] Considerations for HRT Use - The 2002 study had flaws, including exclusively studying women who were on average 10 years post-menopause with an average age of 63, a demographic already vulnerable to cardiovascular disease [8] - The study only evaluated one delivery method (a daily pill combining estrogen and progesterone), while delivery methods have improved since then [9] - Contraindications for HRT include a predisposing risk to blood clots or active breast cancer, but these are rare [14] - Doctors generally don't prescribe hormone therapy if you're over age 60 or more than 10 years after the onset of menopause [18] - Estrogen reduces cardiovascular risk in post-menopausal women by 30 to 50% [21]

If you were talking to the American public, what would your research do for them. >> My research has the potential to prevent their daughters and their wives and their cousins from developing breast cancer. And I don't think any taxpayer would want to interfere with progress on a project like that.>> Joan Buggie is director of the Lewig Cancer Center at Harvard Medical School. For 50 years, she has applied for and won competitive federal grants that helped uncover how tumors form and resist treatment and di ...

Health & Wellness - Breast cancer in individuals in their 20s or 30s presents distinct challenges and concerns [1]

Personal Health & Genetics - The individual had a 50% chance of inheriting a mutated breast cancer gene (BA) from her mother [4] - Genetic testing revealed a 90% lifetime risk of developing breast cancer and a 60% lifetime risk of ovarian cancer [5][7] - Doctors recommended a double mastectomy and removal of ovaries as preventative measures [7] Coping & Resilience - The individual chose to undergo surgeries out of love for her future and children, not out of fear [9] - The individual received a healing tattoo of a willow tree, symbolizing resilience, to reclaim her body and remind herself that she is more than her scars [11][12] - Sharing scars and stories can heal and empower others to face their own challenges [13][14] Societal Impact & Visibility - The world often encourages flawlessness, but real power lies in facing challenges [3] - Hiding scars isolates individuals, while visibility promotes healing and gives others permission to show their own scars [12][13] - Real strength comes from stepping into the storm and choosing to stand, even with scars [13]

What are the odds that you’ll get breast cancer in the next few years? Soon, AI might have the answer https://t.co/U8kKX0aHLs ...

FDA & HRT Treatment Overview - FDA is clarifying the use of hormone replacement therapy (HRT) for perimenopause and menopause, suggesting previous risk assessments may be overstated [1] - The central argument revolves around whether the benefits of HRT outweigh the risks, particularly concerning stroke, blood clots, dementia, and breast cancer [3][6][8] Risk Assessment & Black Box Warning - Current medication labels include a black box warning about increased risks of heart disease, heart attack, strokes, and breast cancer [2][5] - The FDA is considering removing the black box warning due to arguments that the benefits of HRT outweigh the risks [5][6] - A 2002 women's health initiative study, with an average participant age of 63, is being re-evaluated, as HRT is often prescribed to women in their late 40s and 50s [6] - The perceived risk of breast cancer from HRT is considered by some to be overblown [7] - Baseline risk of developing breast cancer is around 13% for women in the United States [3][4] Benefits of HRT - Potential benefits of HRT include reduced risk of dementia and Alzheimer's, prevention of bone loss, and alleviation of menopause symptoms like hot flashes, poor sleep, and brain fog [8] - Estrogen, a key component of HRT, aids neurotransmitter function, potentially lowering the likelihood of dementia and Alzheimer's [9][10]

Health Considerations - Breast cancer in individuals in their 20s or 30s presents unique challenges [1]