[Music] When I was about to turn 35, I was a very lucky guy. I was healthy. I was fit, fitter than today.Um, and I was pursuing a PhD in astrophysics. I was living my dream until chaos hit me right here on earth. It came with three simple words.You have cancer. Okin lymphoma, a blood cancer, very aggressive type. And suddenly my whole world collapsed.My doctor, she tried to light on the mood by tell me jokes about Sheldon Cooper from the Big Bang Theory. But I quite didn't laugh to that joke. The other joke ...

In 2019, I was preparing for one of the most toughest exams in India. That is the UPSC civil services exam. But life had planned a different more challenging and a tough exam for me.At the age of 29, when I was at the peak of my preparation, I was diagnosed with stage three cancer. Today, I'm here not just to tell you about my painful story, but to tell you about a few life lessons of breaking boundaries as a cancer survivor. Hi, I'm Apurva Kanulkar.I'm the co-founder of Infinite Minds and the president of ...

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AI驱动的药物发现引擎 - Isomorphic Labs 正在构建一个药物设计引擎，旨在为不同疾病领域和适应症设计新的分子，甚至适用于不同的药物形式[2] - 该引擎由一系列AI模型驱动，需要大约六个类似AlphaFold的突破性技术共同作用[3] - 这些模型包括预测蛋白质结构、分子结合强度以及药物安全性和吸收性的能力[3][6] 传统药物发现的变革 - 传统药物设计是迭代的，耗时且成本高昂，而Isomorphic Labs 正在将这一过程转移到虚拟世界，在计算机上进行设计和测试，从而缩短时间并提高效率[8][9][10] - 通过在计算机上进行多次迭代，选择最佳结果进行实验室测试，从而跳过步骤，更快地获得更好的结果[10] 模型能力与挑战 - AlphaFold 已经解决了蛋白质折叠问题，但仍需要提高模型的准确性，并理解分子如何与身体的不同部分相互作用[11][12][13] - 分子空间巨大（约10的60次方），需要生成模型和搜索过程来有效地搜索整个空间，从而减少需要实验室测试的分子数量[15][16] 数据策略与质量 - 机器学习依赖于高质量的数据，Isomorphic Labs 拥有全面的数据战略，利用公共数据、历史数据以及专门为机器学习模型创建的湿实验室数据[24][25] - 公司在理解、摄取、清理数据以及从中提取信号方面投入了大量精力[26] 通用性与可重用性 - Isomorphic Labs 专注于构建通用的技术，可以应用于任何靶点、任何疾病领域，甚至任何不同的药物形式[27][28] - 通用模型更具挑战性，但可以创造针对长期未解决的问题的全新化学物质[30][31] 疾病领域重点 - 公司专注于免疫学和肿瘤学，因为这些领域的临床试验更易于处理，可以在更短的时间内完成，并且对患者的影响很大[33][34] - 目标是将癌症转变为一种慢性疾病，患者可以通过药物治疗获得正常的寿命，这可能在几年内实现[36][37] 模型能力与应用 - 这些模型可以应用于整个人类蛋白质组，并且由于神经网络模型运行速度快，可以并行分析数千个蛋白质[39] - 这改变了实验设计，因为在实验世界中，一次只能研究一个蛋白质[40] 合作与里程碑 - 与诺华和礼来等公司的合作非常密切，在一些具有挑战性的靶点上取得了良好的进展[44] - 在某些情况下，已经识别出与以前未知的蛋白质结合的首批化学物质[45] 未来展望 - 目标是在2-3年内将AI药物发现过程缩短至几个月，关键在于提高计算机实验结果的预测准确性[47][48][49] - 展望未来，AI工具可以帮助诊断疾病，并提供相应的药物治疗，从而对人类健康和疾病产生重大影响[50][51]

Core Message - Life adversities, like cancer, are unwanted gifts that can be returned, exchanged, regifted, or shelved [5][6][9][11][21] - Integrating these unwanted gifts into one's identity can lead to personal growth and resilience [9][22][26] - The experience of adversity can foster compassion, consideration, sensitivity, and caring in individuals [21] Cancer Experience & Impact - A cancer diagnosis evokes terror and enters one into an unimaginable world [3] - The speaker experienced a sense of changing identity and beauty, shame, disfigurement, and devastation after being diagnosed with cancer at 37 [6][7] - The speaker had a breast cancer recurrence seven years after the initial diagnosis and developed skin cancer twice [14] - The speaker's children's conversations shifted from "boooos in her boobies" to life and death discussions during the second cancer experience [19] Coping & Growth - Taking care of oneself can aid in early detection and tolerance of treatments [17] - Resiliency is developed daily by showing up, rewiring neuropathways, and coping with adversity [23] - The speaker chooses not to return, exchange, or regift life, embracing it as a wondrous gift [24] - The speaker emphasizes the importance of grasping onto empowering coping techniques during challenging times [24][25]

Health Impact of 9/11 Toxic Exposure - First responders are battling chronic illnesses due to toxic exposure at disaster sites [1] - Common initial health issues included coughing, asthma, sinus problems, and gastroesophageal reflux disease (GERD), alongside anxiety, PTSD, and depression [7][8] - Over time, chronic conditions like COPD and lung scarring (fibrosis) emerged [8] - Thousands of cancer cases are now being seen, including severe cancers, with early cancers predominantly being blood cancers [9] Program & Funding Needs - Northwell's program provides healthcare to nearly 5,000 first responders, offering annual exams, physicals, blood work, chest X-rays (every other year), breathing tests, and cancer screenings [4][5] - The World Trade Center Health Program monitors and treats individuals affected by 9/11 [12] - There is a need for continued funding to ensure timely and seamless care for affected individuals [11][13] - 9/11-linked cancers have increased by a shocking 143% in the last five years, highlighting the growing need for support [10] Ongoing Suffering - First responders are still getting sick and suffering 24 years later [16] - The 9/11 responder and survivor funding act is currently stalled in Congress [14]

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Core Argument - The presentation emphasizes the importance of acknowledging both the positive and negative aspects of life to cultivate genuine gratitude [12][17][18][21] - It suggests that recognizing both "story one" (difficulties) and "story two" (blessings) leads to a more complete and realistic perspective ("story three") [12][13][19][20] Psychological and Health Benefits of Gratitude - Research indicates that focusing on positive aspects ("tailwinds") can enhance happiness, optimism, and positive emotions [15] - Medical studies suggest gratitude can calm the nervous system, boost immunity and heart health, improve sleep, and strengthen relationships [16] - Psychologists advise practicing gratitude with discernment, ensuring it is realistic and honest [17] Personal Anecdotes - The presentation includes personal stories of hardship, including family illness, loss, and personal health challenges [1][2][3][4][5][6] - It also shares stories of positive experiences, such as a loving family, successful career, and travel [7][8][9][10][11] - The speaker highlights a 35-year teaching career and achieving a PhD after surviving stage four cancer [10] Practical Application - The presentation advocates for a mindset of deep thankfulness for all of life, rather than simply keeping a gratitude journal [20] - It suggests that cultivating gratitude can help individuals embrace both the difficult and the fabulous aspects of their lives [21]

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