Core Insights - Rigel Pharmaceuticals reported strong financial performance in 2025, with record net product sales and significant cash generation, anticipating continued growth in 2026 [2][4][11] Financial Performance - Preliminary total revenue for Q4 2025 is expected to be approximately $69.8 million, a 21% increase from $57.6 million in Q4 2024 [5] - For the full year 2025, total revenue is projected to be $294.3 million, up from $179.3 million in 2024, representing a growth of 64% [5] - Net product sales for 2025 are expected to be $232.0 million, a 60% increase compared to 2024 [7] Product Sales Breakdown - Q4 2025 net product sales include: - TAVALISSE: $45.6 million, up from $31.0 million in Q4 2024 - GAVRETO: $10.2 million, up from $8.1 million in Q4 2024 - REZLIDHIA: $9.6 million, up from $7.4 million in Q4 2024 [5] Clinical Development - Rigel is advancing its Phase 1b clinical study of R289 for lower-risk MDS, with preliminary data indicating 33% of patients achieved red blood cell transfusion independence [9] - The company plans to complete enrollment in the dose expansion phase of the R289 study by the second half of 2026 and share preliminary results by the end of 2026 [9][11] 2026 Outlook - Rigel anticipates total revenue for 2026 to be between $275 million and $290 million, with net product sales projected at $255 million to $265 million [11] - The company expects to report positive net income for the full year 2026 while funding existing and new clinical development programs [11]

Health & Medical Industry - Former Republican senator Ben Sasse diagnosed with metastasized, stage-four pancreatic cancer [1]

Despite pressure from the administration, a rough start to the year, biotech has seen a rebound this year. Our next guest is betting that that recovery will continue into 2026. So joining us now, Salivine Richtor.She is the lead US biotech analyst at Goldman Sachs Research. And Salivine, it's great to have you on the show. Welcome.>> Thank you for having me. What's interesting to me is that these names of these, you know, these stocks of these pharma companies that did inc this deal with the president just ...

Hi, my name is Sophia and I'm 13 years old. I want to take you back to March 2020. I was only seven.One day, school closed. The streets went quiet. People stopped hug hugging and suddenly the world felt different.At first, I thought it was a long holiday, but it wasn't. It was the start of something big, something scary, something called a pandemic. A pandemic was a long, unfamiliar word I didn't understand.What did it mean. And how is it different from words I was used to, like the cold or a flu. A pandemi ...

Good Friday morning. We've been tracking extreme weather all week >> and from coast to coast, it's far from over as we head into the weekend. It is December 12th. This is today. >> Double trouble. The flooding emergency only growing in the Pacific Northwest. >> My house is underwater and I don't know what's left. More than a 100,000 already evacuated and even more expected with rivers still rising. We're there live and how's monitoring a new winter storm on the move set to bring snow from the Rockies to the ...

Hey everyone, my name is Jean King and I get to be on this TEDex red carpet here because I got to work at top tech companies like LinkedIn, Meta, and Figma. And I grew my online audience to almost 400,000 friends. But to be clear, this talk isn't about how I landed dream jobs.It's not about how I grew on LinkedIn. It's actually about the moments when life punched me in the face and forced me to get back up because life wasn't always this good. At 23, my very first job out of school, I remember my manager pu ...

Thank you very much for all you attending and Allison for your lovely work. It always takes a lot of work to organize anything in life, I can assure you. And Allison's done a fantastic job for us speakers and for all you out there.Hopefully I can just match her brilliance. Okay, my story starts on the 25th of November 2019. I was sitting in my house in Portugal with my wife and I said, "Gee, I've got this terrible back and I'd had an MRI and I got that call. Some of you might have had that call already. Som ...

Cancer survivor scales Kilimanjaro for charity https://t.co/2XorQWnUKH ...

Overcoming Adversity - The speaker, a teacher, shares her experience of being diagnosed with breast cancer after 30 years of teaching [1] - A student's words of encouragement ("You're a soldier, miss") became a source of strength during her cancer journey [1] - The speaker reflects on her difficult relationship with her mother and how teaching helped her understand her mother's hardships [3][4] - The speaker found solace and healing in the words and actions of her students during her cancer treatment [6][7] The Power of Youth - Teenagers possess unfiltered honesty and unrehearsed kindness, offering wisdom beyond their years [2] - Young people approach adversity like poets, offering empathy and belief in healing [12] - Generosity and philanthropy are not limited to older adults; some of the most philanthropic souls are under 18 [13] The Impact of Teaching - Teaching provided joy and acceptance, transforming the pain from her upbringing into a positive force [6] - Students' words served as a "lifeboat" during the speaker's cancer battle [7] - The classroom is a sanctuary of becoming, where kindness, perseverance, and vulnerability matter [11] - The speaker's legacy lies in the words her students have etched in her heart, providing courage and sunlight [17]

Health & Personal Tragedy - Tatiana Schlossberg, granddaughter of President John F Kennedy, reveals terminal diagnosis of acute myeloid leukemia in The New Yorker essay [1][4] - Doctors estimate she may only have a year to live following diagnosis after delivering her second child in 2024 [4][5] - Median survival rate for this form of cancer is 6 to 18 months [6] - She underwent multiple rounds of chemotherapy and an allogeneic stem cell transplant from her sister [5][6][7] Family & Societal Impact - Tatiana criticizes her cousin, Robert F Kennedy Jr, for his vaccine skepticism, stating it is an embarrassment to her family, given her immunocompromised condition [9] - The essay highlights the importance of vaccines for immunocompromised individuals [10] - Maria Shriver encourages readers to read Tatiana's extraordinary piece [12]