Core Insights - The article discusses the complex process of aging and the importance of finding effective strategies to combat age-related changes, which could improve overall health and extend healthy lifespan [2] - Various promising strategies have been identified, including mTOR inhibitors, senolytics, NAD enhancers, taurine supplements, intermittent fasting, caloric restriction, and cellular reprogramming [2] - An ideal anti-aging method should involve drug-based approaches, have good safety profiles, be applicable to various age-related diseases, and exhibit potential synergistic effects with other treatment targets [2] Summary by Sections - The need for practical methods to combat aging and related degenerative diseases is emphasized, highlighting the role of GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) in insulin release and metabolic regulation [5] - GLP-1 receptor agonists (GLP-1RAs) have shown significant efficacy in treating diabetes and obesity, with additional benefits in cardiovascular health, cognitive decline, and certain cancers [6] - Recent research indicates that GLP-1RAs can induce broad anti-aging effects in aged male mice, with significant improvements observed after 30 weeks of treatment starting at 11 months of age [6][10] - The study found that the anti-aging effects of GLP-1RAs are dependent on GLP-1R in the hypothalamus, suggesting a brain-body axis regulating aging [7][10] - The multi-omic effects of GLP-1RA treatment were found to be significantly similar to those of mTOR inhibitors, indicating a potential new avenue for anti-aging therapies [7][10]