以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 限时进食（TRE）正在掀起一场健康革命，这项源自古老智慧的新型饮食模式已成为当代健康生活的标志性实践。从社交平台到健身社 群，从16: 8轻断食到5: 2间歇性禁食，各种改良版的进食方案层出不穷，俨然构建起一个庞大的限时饮食生态系统。最新发表在 《Na t ur e Me di c i ne》的研究为此热潮提供了坚实的科学依据：仅仅坚持三个月的"过5不食"（即每日进食时间控制在5小时以内），就 能显著减少腹部皮下脂肪堆积、降低空腹及夜间血糖水平，展现出惊人的代谢调节功效。 这项突破性研究揭示了限时进食远不止于体重管理的表层效益。在科学验证的加持下，TRE已从时尚生活方式跃升为改善代谢健康的有 效干预手段。数据显示，这种进食模式不仅能帮助人们获得理想体型，更重要的是可以调节血糖代谢、优化脂肪分布，甚至展现出潜在 抗衰老特性。这些发现为代谢综合征、糖尿病等慢性疾病的预防和管理提供了全新思路，也让限时进食从流行趋势转变为具有循证医学 价值的健康策略 ...

Core Viewpoint - Taurine deficiency is identified as a potential driver of aging, with supplementation showing promise in extending healthspan and lifespan in various model organisms [3][7]. Group 1: Research Findings on Taurine - A study published in Science on June 9, 2023, suggests that taurine deficiency contributes to aging, and its supplementation can slow aging in model organisms, extending the healthspan of middle-aged mice by 12% [3][7]. - Subsequent studies in top journals like Cell and Nature have revealed taurine's new functions, including enhancing cancer treatment efficacy and anti-obesity effects [3]. - However, a study published in Nature on May 14, 2025, indicates that taurine in the tumor microenvironment may promote leukemia cell growth, suggesting a complex role of taurine in cancer [4]. Group 2: Critiques and Counterarguments - A study published in Science on June 5, 2025, questions taurine as an aging biomarker, showing no significant correlation between taurine levels and aging [5]. - Research published in Aging Cell on August 11, 2025, assessed 137 adults aged 20-93 and found no relationship between serum taurine levels and age, muscle mass, strength, or physical function [8][10]. - The findings indicate that taurine deficiency is unlikely to be a primary driver of human aging, challenging previous assumptions about its role [12].

"时间就是金钱"，但对于富豪群体来说，"时间"甚至比金钱更珍贵。近年来，频频有媒体报道高净值人群如何愿意投入高额金钱，只为延长和提升生命的每 一个维度。 2020年，特拉维夫大学一项关于2.0ATA高压氧的实验震动全球：吸三个月高压氧后，受试者细胞端粒延长20%以上，衰老细胞减少10%-37%。这一成果经 《Aging》权威期刊刊载后，高压氧疗及相关产业在全球迎来爆发。国产品牌瑞健·未来Rlab迅速占据国内高压氧舱行业高地，其新一代"大方舰"单价40万， 依然吸引众多高净值客户争相体验、抢先购入。 风口之下，质疑也在发酵。不少媒体引用专家观点，称"青春舱"只是收割有钱人的"智商税"，"专割有钱人韭菜"。 各方争议不断，真相究竟如何？ 1. 明星拥簇，富豪争抢："青春舱"成圈层新宠 高压氧最初广泛应用于医疗领域，用于减压病、一氧化碳中毒等急症。随着科研的深入，其应用高压氧舱逐渐扩展到抗衰老、改善睡眠质量等方面，日益受 到追求高品质生活人群的青睐。 需求火爆的同时，关于高压氧舱的争议声也甚嚣尘上。许多报道直接把"青春舱"定义为"智商税"，调侃它专门为有钱人打造"高价虚荣"。舆论焦点聚集在： 高价是否真的等于效果？ ...

Core Insights - The company reported a revenue of 3.532 billion yuan and a net profit of 737 million yuan for the first half of 2025, showing a narrowing decline in revenue and a positive growth rate in net profit in the second quarter [1] Group 1: Financial Performance - The revenue for the first half of 2025 was 3.532 billion yuan, with a net profit of 737 million yuan attributed to the company's innovative product drive and operational efficiency improvements [1] - The second quarter saw a year-on-year reduction in revenue decline, while net profit growth turned positive [1] Group 2: Market Trends and Strategies - Sales of dietary supplements in pharmacies saw a year-on-year decline of approximately 25% from January to May 2025, prompting the company to focus on consumer-centered solutions [3] - The company is concentrating on basic nutrient categories with high penetration and frequency of purchase, while also enhancing high-quality, cost-effective products [3] - New product launches have shown growth, contributing to an increase in market share, with notable performance in both offline and online channels [3] Group 3: Research and Development - The company is advancing its research in areas such as anti-aging, precision nutrition, and biosynthesis technology, with recent findings published in prestigious journals [4] - The company has partnered with China's Antarctic research team to provide specialized nutritional products, showcasing its commitment to leveraging research for product innovation [4] Group 4: Future Outlook - According to industry reports, the company is expected to see improved performance starting from the second quarter of 2025 due to easing base pressure, demand recovery, new product launches, and operational efficiency [4] - The company is also accelerating its expansion into overseas markets, aiming to create more health value for consumers as new products continue to be released [4]

Core Viewpoints - Semaglutide is recognized as a significant medical breakthrough with potential applications beyond obesity and sleep apnea, including cardiovascular health and various diseases [4][6] - The drug shows promise in anti-aging effects, particularly in populations at risk of accelerated aging, such as HIV patients [6][8] Group 1: Medical Breakthroughs - Semaglutide is being considered for broader applications, including treatment for heart failure, arthritis, Alzheimer's disease, and cancer, due to its cardiovascular metabolic health benefits [4][6] - The drug's potential to improve health outcomes and delay aging has been highlighted in recent studies, indicating its transformative impact on cardiovascular care [6][13] Group 2: Research Findings - A recent study published on medRxiv demonstrated that semaglutide can slow down epigenetic aging in HIV patients, providing clear evidence of its effects on biological aging markers [7][10] - The study involved 108 participants, showing significant reductions in various epigenetic clocks, with notable decreases in biological age indicators such as PhenoAge and OMICmAge [10][11] Group 3: Implications for Aging - Semaglutide may disrupt "obesity epigenetic memory" in fat tissue, potentially offering further support for its role in delaying aging [12] - The drug has shown significant improvements in organ-specific aging markers, including reductions in biological age for the brain, heart, and kidneys [11] Group 4: Clinical Trials and Outcomes - The Select trial involving over 17,600 patients indicated that semaglutide significantly reduced all-cause mortality, particularly in cardiovascular disease and COVID-19 related deaths [13] - The drug's use was associated with a lower mortality rate of 2.6% compared to 3.1% in the placebo group, highlighting its effectiveness in high-risk populations [13]

Core Viewpoint - The article discusses new evidence regarding nicotine's potential anti-aging effects, suggesting that nicotine can reprogram aging-related metabolism and protect against motor decline in mice [3]. Group 1: Research Findings - A study published by researchers from the Shenzhen Institute of Advanced Technology indicates that chronic low-dose nicotine acts as an activator of NAD⁺ biosynthesis, improving glucose metabolism and cognitive function in mice [8]. - The research highlights that the beneficial effects of nicotine occur at significantly lower concentrations than those typically associated with smoking, emphasizing the need for further studies on nicotine dosage and duration [10]. - The study also found that long-term oral nicotine treatment can mitigate age-related declines in motor function in mice, with no pathological changes observed in peripheral organs related to metabolism [11][13]. Group 2: Aging and Metabolism - Aging is characterized by systemic physiological deterioration, including metabolic dysregulation and reduced physical activity, which are critical factors for healthy aging [5]. - Recent advancements in aging research utilize multi-dimensional omics and machine learning to depict biological aging trajectories, revealing the interconnectedness of energy metabolism, mitochondrial efficiency, and nutrient signaling networks [6]. - The decline in NAD⁺ levels during aging negatively impacts cellular energy homeostasis and genomic integrity, while restoring NAD⁺ can alleviate age-related decline [6]. Group 3: Nicotine's Biological Activity - Epidemiological data show a paradoxical relationship between smoking and certain diseases, where nicotine may have protective associations against conditions like ulcerative colitis and Parkinson's disease [7]. - The study indicates that nicotine influences the gut microbiome, which plays a crucial role in overall physiology, and its effects vary depending on conditions, necessitating context-specific analyses [10]. - Nicotine's impact on sphingolipid metabolism is linked to improved energy metabolism and reduced accumulation of neurotoxic ceramides, which are associated with age-related muscle dysfunction [13][15].

以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 限时进食（TRE）正在掀起一场健康革命，这项源自古老智慧的新型饮食模式已成为当代健康生活的标志性实践。从社交平台到健身社 群，从16: 8轻断食到5: 2间歇性禁食，各种改良版的进食方案层出不穷，俨然构建起一个庞大的限时饮食生态系统。最新发表在 《Na t ur e Me di c i ne》的研究为此热潮提供了坚实的科学依据：仅仅坚持三个月的"过5不食"（即每日进食时间控制在5小时以内），就 能显著减少腹部皮下脂肪堆积、降低空腹及夜间血糖水平，展现出惊人的代谢调节功效。 这项突破性研究揭示了限时进食远不止于体重管理的表层效益。在科学验证的加持下，TRE已从时尚生活方式跃升为改善代谢健康的有 效干预手段。数据显示，这种进食模式不仅能帮助人们获得理想体型，更重要的是可以调节血糖代谢、优化脂肪分布，甚至展现出潜在 抗衰老特性。这些发现为代谢综合征、糖尿病等慢性疾病的预防和管理提供了全新思路，也让限时进食从流行趋势转变为具有循证医学 价值的健康策略 ...

Group 1 - The global anti-aging product market is projected to reach $266.2 billion by 2024, with a compound annual growth rate (CAGR) of 8% driven by an aging population [2] - In January 2024, the State Council of China officially recognized the anti-aging industry, marking a significant policy shift that is expected to lead to clearer industry standards and regulatory frameworks [3] - The aging population in China, with over 19% aged 60 and above, is driving demand for anti-aging products, while younger generations are also emerging as significant consumers due to heightened health awareness [3] Group 2 - The anti-aging market is thriving across multiple sectors, including aesthetic medical institutions, where non-surgical facial rejuvenation projects are experiencing rapid growth [4] - The health supplement market is seeing substantial demand for oral anti-aging products, with collagen-based products alone exceeding a market size of $10 billion [5] - Smart home devices for anti-aging, such as radiofrequency beauty devices and laser hair removal instruments, are gaining popularity, significantly impacting traditional beauty salon market shares [7] Group 3 - Advances in life sciences and technology are propelling the anti-aging industry, with stem cell technology being explored for skin rejuvenation and disease treatment [8] - Research into molecular mechanisms of aging is ongoing, with major biopharmaceutical companies focusing on developing drugs targeting pathways like mTOR and AMPK to potentially extend healthy lifespan [8] - Synthetic biology is being utilized to efficiently produce rare natural anti-aging active substances, reducing costs and increasing availability for consumers [8] Group 4 - The anti-aging market is transitioning from rapid growth to a phase of standardization and technological advancement, with the potential for significant growth in the health sector [10] - The industry is becoming a key growth area within the broader health market, driven by both technological innovations and changing consumer demands [10]

Core Insights - The research led by Chinese scientists reveals that extracellular vesicles from antler blastema progenitor cells can reverse bone loss and mitigate aging-related phenotypes in mice and macaques, providing a new treatment strategy for age-related diseases such as Alzheimer's and osteoporosis [1][3][11] - The findings are expected to drive the traditional deer industry towards biotechnology, creating a new ecosystem that combines ancient Chinese medicine wisdom with modern biotechnological advancements [3][4][18] Company Overview - Jilin Aodong (000623) is the largest deer product processing company in China, with over 60 years of experience in breeding sika deer and continuous research on deer antler [3][4][18] - The scientific discoveries related to deer antler have validated the traditional efficacy of Jilin Aodong's product, Anshen Bnona Liquid, which is believed to contain "longevity" secrets that will be gradually unveiled with the research outcomes [3][12][16] Market Potential - Jilin Aodong aims to integrate traditional deer antler value with cutting-edge biotechnology, potentially capturing a significant share of the "brain health" market, which is projected to be worth hundreds of billions [4][18] - The company has a strong foothold in the market, holding 60%-70% of the national market share for Anshen Bnona Liquid, which generates over 700 million yuan in annual sales [16][17] Research and Development - The research on deer antler regeneration has opened new avenues for anti-aging interventions, particularly in reversing bone loss and improving multi-organ aging [11][19] - Jilin Aodong has been actively investing in research and development, achieving breakthroughs in deer breeding technology and establishing a comprehensive disease prevention system [19][20] Policy Support - The company benefits from favorable government policies aimed at promoting the deer industry, including the recent development plan for the sika deer industry (2025-2029) that encourages the exploration of classic formulas and modern biotechnological applications [20][21] - Jilin Aodong has already obtained GMP compliance and "blue hat" certification for its health products, positioning itself well to leverage policy support for quality enhancement [20]

Group 1: Health Impacts of High Temperatures - Extreme heat poses significant health risks, including heatstroke and accelerated aging processes in humans [1] - High temperatures induce oxidative stress, disrupt protein homeostasis, activate inflammatory pathways, and directly age skin and organs [1][3] - Chronic inflammation triggered by high temperatures can silently damage various body tissues [3] Group 2: Antioxidant Properties of Astaxanthin - Astaxanthin, a potent antioxidant, can penetrate cell membranes and effectively neutralize free radicals throughout the body [3] - It inhibits the production and release of inflammatory factors such as IL-6 and TNF-α, providing a balanced anti-inflammatory effect [3][5] - Astaxanthin offers protective benefits against UV-induced skin damage, reducing the penetration and harm caused by UVA and UVB rays [5] Group 3: Industry Leadership and Product Development - Green A Bio is a leading player in the astaxanthin industry, having developed proprietary technologies that break the technological monopoly held by the US and Japan [7] - The company has launched innovative products, including the "Red A Aista" and the anti-aging astaxanthin series, which combine natural astaxanthin with GABA and collagen peptides [7] - The growing medical research on astaxanthin suggests expanding applications in anti-aging and disease prevention, positioning it as a key health supplement [7]