Core Viewpoint - The combination of GLP-1 medication and regular exercise significantly enhances weight loss effects and reduces weight regain by over 60% after discontinuation of the drug [2][5][11]. Group 1: Research Overview - A two-year study targeted obese individuals with a BMI of 32-43 kg/m², starting with an 8-week low-calorie diet that resulted in an average weight loss of 13.1 kg [3]. - Participants were divided into four groups: placebo, liraglutide only, exercise only, and liraglutide + exercise [3]. Group 2: Results and Findings - Participants using liraglutide alone regained an average of 6.0 kg after one year, while the exercise group only regained 2.5 kg, indicating a 58% reduction in weight regain [5]. - By week 104, the combined group lost an additional 5.1 kg compared to the liraglutide-only group, with a body fat percentage decrease of 2.3% [5]. Group 3: Exercise Insights - The study emphasizes that significant results can be achieved without high-intensity exercise; just two hours of exercise per week can prolong the weight loss benefits of medication [7]. - Exercise types can be tailored to individual health conditions, ranging from brisk walking for those with lower fitness levels to running or cycling for healthier individuals [7]. Group 4: Clinical Implications - The research provides critical insights for obesity treatment, suggesting that healthcare providers should create personalized exercise plans alongside GLP-1 prescriptions to improve treatment success rates [11]. - The findings indicate that structured exercise can maintain weight and body composition improvements even after the intervention ends, contrasting with the diminishing benefits of liraglutide alone after one year [11][15]. Group 5: Future Research Directions - Future studies will explore the impact of different types of exercise, such as strength training and aerobic activities, on the effectiveness of GLP-1 medications [11]. - There will also be a focus on enhancing patient adherence to exercise regimens and the long-term effects of combined interventions on cardiovascular health [11].