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加科思-B(01167):pan-KRAS 抑制剂价值重估空间大
Huachuang Securities· 2026-02-24 08:04
Investment Rating - The report assigns a "Strong Buy" rating to the company for the first time [5][8]. Core Insights - The company has significant potential for value re-evaluation, particularly with its pan-KRAS inhibitors and strategic collaborations, notably with AstraZeneca [5][6]. - The first commercial product, KRAS G12C inhibitor Goleirese, has been approved and is expanding its indications, contributing to cash flow [5][33]. - The next-generation ADC platforms, tADC and iADC, are expected to overcome traditional treatment limitations and enhance the company's competitive edge in oncology [5][6][7]. Financial Summary - Projected total revenue (in million CNY) for 2024A, 2025E, 2026E, and 2027E is 156, 234, 627, and 508 respectively, with year-on-year growth rates of 145.1%, 50.5%, 167.6%, and -19.1% [5][8]. - Expected net profit attributable to shareholders (in million CNY) for the same years is -156, -15, 313, and 192, with growth rates of 56.6%, 90.7%, 2,258.6%, and -38.6% [5][8]. - The estimated price-to-earnings ratio (P/E) for 2026 is 14, and for 2027 is 23, indicating a potential for profitability [5][8]. Product Pipeline and Collaborations - The company has developed a differentiated innovation drug research system targeting difficult drug targets like KRAS, with a focus on pan-KRAS inhibitors [6][33]. - The collaboration with AstraZeneca for the pan-KRAS inhibitor JAB-23E73 is expected to accelerate the global value realization of the company's pipeline [5][6][7]. - The company is advancing its ADC platforms, with tADC utilizing KRAS inhibitors as payloads and iADC using STING agonists, aiming to address challenges in traditional therapies [5][6][7]. Market Position and Competitive Landscape - The company is positioned to leverage its innovative drug development capabilities in the oncology sector, particularly with its KRAS-targeted therapies [5][6][7]. - The competitive landscape for pan-KRAS inhibitors is evolving, with the company’s JAB-23E73 showing promising clinical data and safety profiles compared to competitors [5][6][7].