Phase 2 randomized, double-blind, placebo-controlled trial planned to evaluate TNX-2900 in children and adolescents (ages 8 to 17.5 years) with Prader-Willi Syndrome under a cleared IND TNX-2900 granted Orphan Drug and Rare Pediatric Disease Designations by the FDA, providing the potential for a Priority Review Voucher upon approval Magnesium-potentiated intranasal oxytocin formulation designed to reduce dose-related inconsistencies in receptor activity CHATHAM, N.J., Sept. 29, 2025 (GLOBE NEWSWIRE) -- Toni ...

Every morning as I walk to school in the neighborhood that I grew up in in Brooklyn, New York, I passed many of the same things. Graffiti cover walls, people standing outside corners who never seem to leave, and sometimes things that a child should never see. Things like used needles, broken glass, and other drug paraphernalia.And also, as you might imagine, the unmistakable exchange of cash for things that at the time were unknown to me. It wasn't unusual to hear sirens or police cars parked outside my sch ...

Drug Use & Addiction - Germany's Ministry of Health indicates 12 million smokers, 16 million (1.6%) ecodependent people, 3 million people with problematic medication use, and 1 million young adults regularly consuming cannabis or illegal drugs [1] - Drug dependence begins when the desire to use drugs arises after the pleasant effects wear off, and this desire is satisfied more and more often [2] - Consumed drugs trick the brain into repeated drug use, leading to addiction [9] Endogenous Drugs & Their Effects - The body has receptors for consumed drugs, primarily located on the surface of nerve cells [2][3] - These receptors are designed to fit the body's own substances, endogenous drugs, which the body naturally produces and have drug-like effects [4] - Endogenous drugs can be stimulated by activities like exercise, singing, social bonding, or sexual activity [5] - Endogenous opioids are stimulated by sexual activity and physical exercise, acting as natural painkillers and mood enhancers [7] - Dopamine, a neurotransmitter, produces feelings of happiness and satisfaction, reinforcing behaviors important for survival [8] Oxytocin & Bonding - Oxytocin, also called the cuddle hormone, plays a major role in mammalian reproduction, strengthening labor during birth and enabling milk flow during lactation [10] - Oxytocin enhances the motivation to care for and bond with offspring by strongly activating the brain's reward system [12][13] - Oxytocin is essential for individual social recognition, enhancing social salience and enforcing the sensory detection of individual social cues [18][19] Activities & Endogenous Drug Release - Physical exercise, like running, boosts endogenous drug-like systems, with elevated levels of oxytocin and cortisol found after running [20][21] - Singing, whether alone or in a choir, has beneficial effects on mental and physical health, increasing oxytocin levels and reducing stress [24][25]

Smiling and Well-being - Smiling, even fake smiling, can trick the brain into recovering from stress faster [9][10] - Smiling at someone can give them a hit of dopamine, making them feel good [10] - Smiling makes individuals more approachable and is contagious [11] - Smiling can lead to the production of dopamine, oxytocin, serotonin, and endorphins, the four happy hormones [12] - Smiling makes individuals 40% more attractive [21] - Smiling has overall long-term effects on well-being and makes individuals more approachable [22] Brain Rewiring and Affirmations - Individuals can rewire their brain in real time by using affirmations [16] - Repeating affirmations can help overcome resistance and change negative thought patterns [17][18] Muscle Memory and Facial Expressions - Facial expressions become etched into the face over time, and individuals can train their face muscles [14][15]