Health & Longevity - VO2 max is more strongly correlated with lifespan than other metrics [1] - Muscle mass, strength, and cardiorespiratory fitness have a higher correlation with all-cause mortality than blood pressure, cholesterol, or smoking [1] - VO2 max measures how much oxygen the body and muscles use to create energy, correlating with longevity [2] VO2 Max Assessment - Individuals can estimate VO2 max using the Cooper test: run for 12 minutes, measure the distance, and use a calculator [3] - Wearable devices can estimate VO2 max, though the number may vary slightly from treadmill tests [3][4] VO2 Max Improvement - Regular running, jogging, or cycling is beneficial, but intense exercise at least once a week is crucial for improving VO2 max [5] - Aim for an "elite" VO2 max category, which is typical for someone two decades younger [4]

Gene Therapy Performance - MinicircleDNA follistatin gene therapy shows potential to increase VO2 max, with one individual reporting an increase comparable to 3 months of training within a week [1] - The individual experienced an almost 50% increase in running endurance with the same effort after the therapy [3] - The individual participated in a reversibility study to turn off the gene therapy and subsequently received the therapy again [3] VO2 Max Data - Baseline VO2max increased by 4.8 ml/kg/min over 2 months of training [4] - VO2max increased by 4.3 ml/kg/min in one week after the gene therapy [4] - VO2max increased by an additional 3.6 ml/kg/min over 3 months of training [4] - The reported VO2max differences exceed the expected 2%-5% per-trial variation of 1-3 ml/kg/min [4] Skepticism and Call to Action - The individual acknowledges skepticism due to the novelty of the treatment and limited public data [5] - The individual encourages others undergoing the therapy to collect and share data [5]