Summary of FibroBiologics Special Meeting of Stockholders Company Overview - **Company**: FibroBiologics (NasdaqGM:FBLG) - **Industry**: Biotechnology, specifically focusing on regenerative medicine and fibroblast technology Key Points from the Meeting Corporate Governance - The meeting was presided over by Pete O'Heeron, Founder, Chairman, and CEO, with other board members and executives present [2][17] - A quorum was established with 54,971,343 votes representing approximately 56% of the total votes available [5] Proposals Voted On 1. **Reverse Stock Split**: Proposal to amend the certificate of incorporation for a reverse stock split at a ratio between 1-for-5 and 1-for-30, approved [9][15] 2. **Issuance of Shares**: Multiple proposals to approve the issuance of shares upon the exercise of outstanding common warrants, all approved: - Up to 12,110,203 shares from a securities purchase agreement dated November 18, 2025 [10][15] - Up to 4,477,614 shares from agreements dated November 24, 2025, and 313,433 shares from an engagement letter dated November 10, 2025 [11][15] - Up to 5,227,275 shares from agreements dated December 14, 2025, and 365,909 shares from an engagement letter [12][15] 3. **Adjournment of Meeting**: Approved to solicit additional votes if necessary [13][15] Corporate Update Highlights - **Mission**: To harness the immune modulation and regenerative potential of fibroblasts to treat and cure chronic diseases [18] - **Clinical Trials**: - Currently conducting a Phase 1/2 clinical trial for diabetic foot ulcers [19] - IND submitted for psoriasis at the end of December 2025, with plans for IND-ready assets for multiple sclerosis and degenerative disc disease [19] - **Financial Position**: Clean balance sheet with $4.9 million in cash as of September 30, 2025, and over 270 issued and pending patents [19][20] Technology and Innovation - **Fibroblast Technology**: - Fibroblasts are positioned as a promising alternative to stem cells for regenerative medicine due to their regenerative and immune-modulating properties [21][22] - Fibroblasts are abundant, well-characterized, and offer advantages in non-invasive sourcing, immune modulation, and cost-effectiveness [22][23] - **Pipeline**: Focus on diabetic foot ulcers, multiple sclerosis, degenerative disc disease, and psoriasis, with potential applications in longevity and cancer treatment [30][31][32] Market Opportunity - **Diabetic Foot Ulcers**: Approximately 33 million diabetes patients develop diabetic foot ulcers, representing a significant commercial opportunity [24] - **Multiple Sclerosis**: Affects 2.9 million globally, with a focus on addressing root causes rather than just symptom management [27] - **Psoriasis**: Affects 123 million worldwide, with current treatments being inadequate; fibroblast modulation offers a new approach [30] Future Outlook - The company aims to become a leader in regenerative medicine, focusing on impactful innovations rather than size [19] - Plans to advance clinical trials and potentially bring products to market rapidly, contingent on FDA approvals and trial results [36] Additional Insights - The meeting emphasized the importance of innovation, teamwork, and a commitment to curing chronic diseases rather than merely managing symptoms [19][20] - The leadership team has over 60 years of combined experience in medical innovation and capital markets, providing strategic guidance for the company's direction [20] This summary encapsulates the key discussions and proposals from the FibroBiologics special meeting, highlighting the company's strategic focus on fibroblast technology and its potential to transform the treatment of chronic diseases.

Market Overview - Major stock indexes declined in premarket trading, influenced by economic reports affecting the Federal Reserve's interest rate decision [1] - Dow Jones Industrial Average futures were down 0.2%, S&P 500 futures also decreased, and Nasdaq 100 futures slipped 0.3% [1] Economic Indicators - The Personal Consumption Expenditures (PCE) price index rose 2.9% year-over-year in December, exceeding economists' expectations [2] - Core inflation increased to 3% from 2.8% in November, aligning with forecasts [2] - U.S. GDP grew at an annualized rate of 1.4%, significantly below expectations and down from 4.4% in the previous quarter [2] Treasury Yields - The 10-year Treasury yield rose slightly to 4.07% following the inflation and GDP reports, although yields are down slightly since the beginning of the year [3] Company Performance - Applovin (APP) shares rose 4% amid reports of developing a social media platform [4] - Grail (GRAL) shares fell nearly 50% after disappointing trial results for a cancer treatment [4] - Akamai Technologies (AKAM) shares dropped 8% due to first-quarter guidance falling short of estimates [4] Commodity Prices - West Texas Intermediate crude oil futures were slightly down at $66.25 per barrel [5] - Gold futures increased by about 1% to $5,050 per ounce, while silver gained 4% to trade at $80.65 per ounce [5] - Bitcoin was trading slightly below $67,000, down from earlier highs above $68,000 [5] - The U.S. dollar index slipped 0.1% to 97.80 [5]

Core Insights - Ardelyx, Inc. (ARDX) reported fourth quarter results, beating revenue expectations but slightly missing on earnings, which negatively impacted market perception [1] Financial Performance - The company achieved revenue growth, surpassing market expectations, but the earnings miss led to a negative market reaction [1] Analyst Background - The analysis is conducted by a professional with a Master's degree in Cell Biology and extensive experience in drug discovery and biotechnology investment, focusing on identifying innovative biotech companies [1] Investment Focus - The emphasis is on evaluating the science behind drug candidates, competitive landscape, clinical trial design, and market opportunities while balancing financial fundamentals and valuation [1] Sector Insights - The biotech sector is characterized by the potential for breakthrough science to yield significant returns, necessitating careful scrutiny of investment opportunities [1]

Core Insights - Ardelyx, Inc. (ARDX) reported fourth quarter results, beating revenue expectations but slightly missing on earnings, which negatively impacted market perception [1] Financial Performance - The company achieved revenue growth, surpassing market expectations, although specific figures were not disclosed [1] - Earnings fell short of expectations, contributing to a negative market reaction [1] Company Background - Ardelyx is involved in biotechnology, focusing on innovative drug development with unique mechanisms of action and first-in-class therapies [1] - The company aims to reshape treatment paradigms through its platform technologies [1]

Core Insights - Senti Biosciences, Inc. is advancing its proprietary Gene Circuit platform for next-generation cell and gene therapies, participating in a Cell & Gene Live virtual event to discuss innovative cell therapy technologies [1][2][3] Company Overview - Senti Bio is a clinical-stage biotechnology company focused on developing cell and gene therapies for incurable diseases, utilizing synthetic biology to engineer Gene Circuits that enhance precision and control in targeting cancer cells while sparing healthy cells [6] Product Development - SENTI-202 is the first Logic Gated off-the-shelf CAR-NK cell therapy designed to target CD33 and/or FLT3 expressing hematologic malignancies, such as AML and myelodysplastic syndrome (MDS), while protecting healthy bone marrow cells [4] - The therapy includes an OR GATE for targeting cancer cells, a NOT GATE to protect healthy cells, and calibrated-release IL-15 to enhance cell persistence and activity [4] - Currently, Senti Bio is enrolling adult patients with relapsed/refractory CD33 and/or FLT3 expressing hematologic malignancies in a Phase 1 clinical trial for SENTI-202, which may become a first-in-class allogeneic treatment for AML/MDS patients [4] Regulatory Designations - The FDA has granted Orphan Drug Designation (ODD) and Regenerative Medicine Advanced Therapy (RMAT) designation to SENTI-202 for treating relapsed/refractory hematologic malignancies, including AML [5]

About this content About Emily Jarvie Emily began her career as a political journalist for Australian Community Media in Hobart, Tasmania. After she relocated to Toronto, Canada, she reported on business, legal, and scientific developments in the emerging psychedelics sector before joining Proactive in 2022. She brings a strong journalism background with her work featured in newspapers, magazines, and digital publications across Australia, Europe, and North America, including The Examiner, The Advocate, ...

Core Insights - Conestoga Capital Advisors reported solid returns in US equities for 2025, with double-digit gains across all major indices [1] - The Conestoga Micro Cap Composite returned -1.91% net of fees in Q4 2025 and 16.24% for the full year, underperforming the Russell Microcap Growth Index [1] Company Overview: Alpha Teknova, Inc. (NASDAQ:TKNO) - Alpha Teknova, Inc. is a biotechnology company that provides critical reagents for the development of biopharmaceutical products [3] - As of February 19, 2026, Alpha Teknova's stock closed at $2.09 per share, with a one-month return of -37.05% and a 52-week loss of 71.95% [2] - The company has a market capitalization of $111.876 million [2] Performance and Market Indicators - Alpha Teknova reported a solid quarter, with positive leading indicators in end markets driven by biotech funding and growth with large pharmaceutical companies [3] - Despite positive indicators, these have not yet translated into sales, leading to a cautious investor sentiment regarding early-stage biotech funding [3] Hedge Fund Interest - Alpha Teknova is not among the 30 most popular stocks among hedge funds, with 12 hedge fund portfolios holding the stock at the end of Q3 2025, an increase from 11 in the previous quarter [5] - While the potential of Alpha Teknova as an investment is acknowledged, certain AI stocks are considered to offer greater upside potential and less downside risk [5]

SAN DIEGO, Feb. 20, 2026 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics, Inc. (NYSE American: CLDI) (“Calidi” or the “Company”), a biotechnology company pioneering the development of targeted genetic medicines, today presented data on its novel approach to the use of BiTEs in solid tumors by utilizing its systemically delivered RedTail platform at the AACR Immuno-Oncology (AACR-IO) conference being held in Los Angeles, California. A link to the poster is available here and on the company’s website. RedTail is C ...

Core Viewpoint - AtaiBeckley Inc. is hosting a Virtual Investor Day on March 6, 2026, to present its mission and pipeline of mental health treatments [1][2]. Company Overview - AtaiBeckley Inc. is a clinical-stage biotechnology company focused on developing rapid-acting, durable, and convenient mental health treatments [3]. - The company's pipeline includes BPL-003 (mebufotenin benzoate nasal spray) for treatment-resistant depression (TRD), VLS-01 (DMT buccal film) for TRD, and EMP-01 ((R)-MDMA HCI) for social anxiety disorder [3]. - BPL-003 is in Phase 3 planning, while VLS-01 and EMP-01 are in Phase 2 clinical development [3]. - The company is also working on a drug discovery program for novel, non-hallucinogenic 5-HT2AR agonists targeting opioid use disorder and TRD [3]. Event Details - The Virtual Investor Day will feature presentations and live Q&A sessions with the executive leadership team and external key opinion leaders [1]. - Investors, analysts, and media members can register for the live webcast, with a replay available afterward on the company's investor website [2].

Core Insights - The biotech company reported that its multi-cancer screening test, Galleri, did not achieve a statistically significant reduction in stage 3 and 4 cancer during a trial conducted in the U.K. [1] Company Summary - The company is focused on developing innovative cancer screening solutions [1] - Galleri is positioned as a multi-cancer screening test aimed at early detection [1] Industry Summary - The trial results highlight challenges in the effectiveness of current cancer screening technologies [1] - The findings may impact the perception and adoption of multi-cancer screening tests in the healthcare market [1]