RAPT Therapeutics (RAPT) FY 2025 Conference September 03, 2025 12:45 PM ET Speaker0Are we live yet? Okay. All right. Thanks everyone for coming. My name is Yatin Zhu.I'm one of the biotech analysts here at Wells Fargo. It is our privilege to have the management team of Wrap Therapeutics here for this fireside chat. With me here is Brian Wong, CEO and President of the company and also Rodney Young, CFO of the company. Brian and Rodney, thank you for being here with us. Thanks for having us.Thanks. Great. I t ...

Protein Degraders to Outmatch Cancer and Autoimmune Disease Investor Presentation September 2025 Important Notice and Disclaimers This presentation contains statements that relate to future events and expectations and as such constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. When or if used in this presentation, the words "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "outlook," "plan," "predict," "should," "will," and ...

Wave Life Sciences Ltd. WVE stock is trading lower on Wednesday after the company shared data from the ongoing Phase 1b/2a RestorAATion-2 Trial of WVE-006 in alpha-1 antitrypsin deficiency.WVE is encountering selling pressure. Review the technical setup here.Alpha-1 antitrypsin (AAT) deficiency is an inherited genetic disorder that reduces the production of the AAT protein, which is crucial for protecting the lungs and liver.Also Read: Wave Life Sciences Stock Jumps On Positive Data From Muscle Disorder Dru ...

Core Insights - Microbix Biosystems Inc. hosted Ontario's Minister of Public and Business Service Delivery and Procurement, Stephen Crawford, to showcase its biotechnology facilities and discuss advancements in diagnostics that can enhance health outcomes and reduce healthcare costs for Ontarians [1][2] - The company has received over C$ 2.0 million in grant funding from the Ontario Together Funds, which has supported the development of state-of-the-art manufacturing capabilities and healthcare products [1][3] - Microbix supplied over 2 million units of Viral Transport Medium (VTM) to Ontario during the pandemic years of 2021 and 2022, including a significant emergency order of 1.2 million units in December 2021 [1] Company Overview - Microbix is an Ontario-based life sciences innovator with over 120 skilled employees, producing proprietary biological products for human health [3][4] - The company manufactures critical ingredients for the global diagnostics industry, including antigens for immunoassays and laboratory quality assessment products (QAPs™) [3] - Microbix's products are distributed in over 30 countries and are supported by a network of international distributors, with various accreditations including ISO 9001 & 13485 and U.S. FDA registration [3][4] Product Development - Microbix develops proprietary products such as Kinlytic urokinase, a thrombolytic drug for treating blood clots, and reagents for molecular diagnostic testing [4] - The company emphasizes its commitment to innovation and the development of Ontario-made products that contribute to global health [2][3]

Core Insights - Immunovant, Inc. presented six-month off-treatment data for batoclimab in uncontrolled Graves' disease patients, indicating potential disease modification and strong durability of response [1][2][3] Study Details - The proof-of-concept study involved a 24-week treatment with batoclimab, followed by a 24-week off-treatment follow-up, focusing on patients with active Graves' disease [3][4] - The key endpoint was the normalization of free triiodothyronine (T3) and free thyroxine (T4) levels without increasing anti-thyroid drug (ATD) doses from baseline [3] Remission Data - Out of 21 patients in the follow-up period, approximately 80% (17/21) maintained normal thyroid function at the end of six months [6][7] - Among the responders, about 50% (8/17) achieved ATD-free remission, while an additional 30% (5/17) were on low ATD doses [6][7] Future Trials - Two potentially registrational trials for Immunovant's lead compound IMVT-1402 in Graves' disease are currently enrolling, with topline readouts expected in 2027 [5][6]

Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses In Unicycive To Contact Him Directly To Discuss Their Options If you purchased or acquired securities in Unicycive between March 29, 2024 and June 27, 2025 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310). [You may also click here for additional information] NEW YORK, Sept. 03, 2025 (GLOBE NEWSWIRE) -- Faruq ...

Zevra Therapeutics (ZVRA) 2025 Conference September 03, 2025 11:30 AM ET Company ParticipantsNeil McFarlane - President, CEO & DirectorConference Call ParticipantsKristen Kluska - Equity Research AnalystKristen KluskaHi, good morning everybody. I'm Kristen Kluska at Cantor, very happy to be hosting Neal McFarlane at Zevra Therapeutics. Thank you for being here today.Neil McFarlaneThanks for having us.Kristen KluskaThis is our first fireside together since I launched coverage earlier in the year so it's been ...

Summary of Arcus Biosciences Conference Call - September 03, 2025 Company Overview - **Company**: Arcus Biosciences (RCUS) - **Focus**: Development of innovative cancer therapies, particularly in the area of HIF-2 alpha inhibitors Key Points and Arguments Product Pipeline and Clinical Trials - **Casdatafan**: - Positioned as a best-in-class HIF-2 alpha inhibitor, with compelling data from 120 patients indicating superior efficacy compared to Merck's belzutafan [6][17] - Total addressable market estimated at $10 billion [7] - Phase 3 studies initiated, including a combination with cabozantinib (cabo) and a collaboration with AstraZeneca for frontline settings [8][10] - Expected rapid enrollment due to investigator enthusiasm [7][11] - **Domzim**: - An anti-TIGIT, anti-PD-1 combination therapy, with data to be presented at ESMO [9][10] - **Quemly**: - A CD73 inhibitor in pancreatic cancer, fully enrolled ahead of schedule, with results expected in the next 12-18 months [12][97] Competitive Landscape - **Comparison with Merck's Belzutafan**: - Casdatafan shows a lower rate of primary progression (15% vs. 35% for belzutafan) and better overall response rates (over 30% vs. just over 20%) [17][18] - Arcus believes their development strategy is superior, focusing on combining with cabo, which is more widely used and easier to manage than Merck's lenvatinib [22][24] Strategic Advantages - **Development Strategy**: - Arcus employs a cleaner statistical analysis plan with a single primary endpoint of progression-free survival (PFS) [30] - Two-to-one randomization in trials to enhance patient enrollment [32] - **Collaboration with AstraZeneca**: - Cost-sharing arrangement for a phase 1b/3 study combining Casdatafan with AstraZeneca's bispecific anti-PD-1/CTLA-4 [40][41] Upcoming Data and Events - **Investor Event**: - Scheduled for October 6, 2025, to present updated data on Casdatafan and other therapies [8] - **Data Readouts**: - Continuous flow of data expected from various studies, including OS data from the Edge Gastric study and the phase 3 study for upper GI cancers [10][66] Market Positioning - **TKI-Sparing Regimen**: - Arcus aims to shift the use of TKIs to later lines of therapy, enhancing patient quality of life by avoiding early toxicities associated with TKIs [49] Other Important Insights - **Safety Profile**: - Casdatafan is expected to have minimal overlapping toxicity with other treatments, which could make it a backbone agent in clear cell renal cell carcinoma (CCRCC) [60] - **Regulatory Landscape**: - No competing phase 3 studies currently exist for Casdatafan, positioning Arcus favorably in the market [35] Conclusion - Arcus Biosciences is in a transformative phase with multiple late-stage clinical trials and a strong competitive position against Merck's belzutafan. The company is focused on delivering innovative therapies with a favorable safety profile and robust efficacy data, aiming to capture significant market share in the oncology space.

Kyverna Therapeutics (KYTX) FY 2025 Conference September 03, 2025 11:00 AM ET Speaker0right, everyone. I think we'll get started with our fireside discussion. My name is Derek Archila. I'm one of the Wells biotech analysts. Very excited to have Qiverna Therapeutics and their CEO, Warner Biddle.Warner, thank you so much for joining us.Speaker1Thanks for inviting us, Derek, and thanks for hosting us. It's been great so far. Awesome. Well I didn't know there was a Las Vegas casino in the middle of Boston. Here ...

Disc Medicine (IRON) 2025 Conference September 03, 2025 10:55 AM ET Company ParticipantsJohn Quisel - CEO & DirectorConference Call ParticipantsKristen Kluska - Equity Research AnalystJohn QuiselReady.Kristen KluskaOkay. Hi. Good morning. I think it's still morning, everybody. I'm Kristen, one of the biotech analysts at Cantor.Very happy to be hosting Disc Medicine. We have doctor John Quisel from the team here. Thank you so much for taking the time to come to our conference today.John QuiselThank you. Grea ...