Immunome, Inc. (IMNM) shares rallied 6% in the last trading session to close at $9.3. This move can be attributable to notable volume with a higher number of shares being traded than in a typical session. This compares to the stock's 0.1% gain over the past four weeks.The sudden price rise can be attributed to growing investor optimism regarding the company’s efforts to develop its lead pipeline candidate, varegacestat, which is currently in late-stage clinical studies for the treatment of desmoid tumors. I ...

Immunome, Inc. (IMNM) could be a solid addition to your portfolio given its recent upgrade to a Zacks Rank #2 (Buy). An upward trend in earnings estimates -- one of the most powerful forces impacting stock prices -- has triggered this rating change.The Zacks rating relies solely on a company's changing earnings picture. It tracks EPS estimates for the current and following years from the sell-side analysts covering the stock through a consensus measure -- the Zacks Consensus Estimate.Individual investors of ...

Shares of Immunome, Inc. (IMNM) have gained 19.1% over the past four weeks to close the last trading session at $9.49, but there could still be a solid upside left in the stock if short-term price targets of Wall Street analysts are any indication. Going by the price targets, the mean estimate of $24.50 indicates a potential upside of 158.2%.The mean estimate comprises eight short-term price targets with a standard deviation of $5.76. While the lowest estimate of $20 indicates an 110.8% increase from the cu ...

Immunome (IMNM) FY Conference June 10, 2025 02:00 PM ET Speaker0 Good afternoon, everyone. Thank you so much for joining us. I'm Salveen Richter, biotechnology analyst at Goldman Sachs. And really pleased to have with us Clay Siegel, who's the president and CEO of Immunome. So to start here, Clay, you formed this company. Maybe you could just level set for everyone in the room who isn't as familiar with regard to your strategy, your pipeline, and really the key focus points you want us to look at in the hal ...

Summary of Immunome (IMNM) FY Conference Call - May 27, 2025 Company Overview - **Company**: Immunome (IMNM) - **Focus**: Development of innovative therapies, particularly in oncology, with a strong emphasis on antibody-drug conjugates (ADCs) Key Points Discussed Advanced Asset: Varagastat - Varagastat, previously known as AL-102, is being developed for the treatment of desmoid tumors - The acquisition of Varagastat was driven by its superior potency compared to competitors like OXIVIO and SpringWorks [4][5] - Phase two data showed an objective response rate (ORR) of 64% for Varagastat, compared to 41% for SpringWorks [6] - The broader phase two cohort showed a 54% ORR, even with a significant portion receiving suboptimal dosing [6] - Emphasis on the quality of life impact of desmoid tumors, which are not typically fatal but severely affect daily living [7][8] - The primary endpoint for the ongoing trial is progression-free survival, but other measures like tumor volume reduction are also critical [8][11] Upcoming Data and Expectations - Top-line data from the phase three Ringside trial is expected in the second half of 2025 [12][13] - Confidence in the timing of data readout is based on event accrual rates and overall data maturity [13] - The company aims to provide a comprehensive data package, including secondary endpoints, at a major medical meeting [14] Market Opportunity - The desmoid tumor market is viewed as having significant potential, with SpringWorks previously achieving $70 million in sales in its first year [22] - Varagastat is positioned to compete effectively against OXIVIO, which has a high enterprise value despite challenges [19][22] ADC Development Strategy - Immunome has assembled a strong team for ADC development, focusing on operational excellence and innovative target exploration [26][28] - The company is pursuing novel targets and underexplored areas rather than established ones, aiming for differentiated ADCs [30][31] - HC74, a proprietary ADC, is highlighted for its unique characteristics that enhance efficacy and overcome resistance [35] Other ADC Programs - The company is advancing multiple ADC candidates, with ongoing IND-enabling studies for several novel solid tumor ADCs [42][44] - Plans to initiate a phase one trial for a lutetium payload radioligand therapy targeting fibroblasts in solid tumors [46][47] Financial Position and Future Plans - Immunome's cash position is strong, with runway extending into 2027 [48] - The company is open to business development opportunities, particularly for assets that can enhance its portfolio without diluting equity [49] Additional Insights - Pain management and patient-reported outcomes are critical secondary endpoints that could differentiate Varagastat in the market [21] - The company is committed to transparency regarding data sharing and aims to present findings in a meaningful context [14][40] This summary encapsulates the key discussions and insights from the Immunome FY Conference Call, highlighting the company's strategic direction, product pipeline, and market positioning.

Shares of Immunome, Inc. (IMNM) have gained 1.1% over the past four weeks to close the last trading session at $8.49, but there could still be a solid upside left in the stock if short-term price targets of Wall Street analysts are any indication. Going by the price targets, the mean estimate of $24.50 indicates a potential upside of 188.6%.The mean estimate comprises eight short-term price targets with a standard deviation of $5.76. While the lowest estimate of $20 indicates a 135.6% increase from the curr ...

Immunome, Inc. (IMNM) could be a solid choice for investors given its recent upgrade to a Zacks Rank #2 (Buy). This upgrade is essentially a reflection of an upward trend in earnings estimates -- one of the most powerful forces impacting stock prices.The sole determinant of the Zacks rating is a company's changing earnings picture. The Zacks Consensus Estimate -- the consensus of EPS estimates from the sell-side analysts covering the stock -- for the current and following years is tracked by the system.The ...

Immunome, Inc. (IMNM) came out with a quarterly loss of $0.52 per share versus the Zacks Consensus Estimate of a loss of $0.66. This compares to loss of $0.34 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 21.21%. A quarter ago, it was expected that this company would post a loss of $0.68 per share when it actually produced a loss of $0.84, delivering a surprise of -23.53%.Over the last four quarters, the company has surpasse ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39580 Immunome, Inc. (Exact name of registrant as specified in its charter) Delaware 77-0694340 (State or oth ...

Financial Performance - As of March 31, 2025, Immunome reported cash, cash equivalents, and marketable securities totaling $317.3 million, including net proceeds of $161.7 million from a financing round in January 2025[9]. - Immunome reported a net loss of $41.6 million for Q1 2025, compared to a net loss of $129.5 million in Q1 2024[9][13]. - Collaboration revenue for Q1 2025 was $2.9 million, up from $1.0 million in Q1 2024[13]. - The total operating expenses for Q1 2025 were $47.6 million, significantly lower than $133.3 million in Q1 2024[13]. - Research and development expenses for Q1 2025 were $36.9 million, with stock-based compensation costs of $2.4 million[9]. - General and administrative expenses for Q1 2025 were $10.7 million, including stock-based compensation expense of $3.3 million[9]. - The weighted-average shares outstanding for Q1 2025 were 79,410,354, compared to 51,544,383 in Q1 2024[13]. Clinical Development - The Phase 3 RINGSIDE Part B study of varegacestat for desmoid tumors completed full enrollment in February 2024, with topline data expected in the second half of 2025[3]. - The Phase 1 clinical trial of IM-1021 began dosing its first patient in February 2025, targeting advanced B-cell lymphomas and solid tumors[4]. - Immunome received IND clearance for IM-3050 in April 2025 and plans to initiate a Phase 1 clinical trial in the second half of 2025[4].