Financial Data and Key Metrics Changes - Sales for the second quarter were $5.9 billion, with a core revenue growth of 1.5% year over year [11] - Gross profit margin was 59.3%, and adjusted operating profit margin was 27.3%, flat year over year [12] - Adjusted diluted net earnings per share were $1.8, up approximately 5% year over year [12] - Free cash flow generated in the quarter was $1.1 billion, with a year-to-date free cash flow to net income conversion ratio of 143% [12] Business Line Data and Key Metrics Changes - Core revenue in the biotechnology segment increased by 6%, with bioprocessing up high single digits [16] - Life sciences segment core revenue decreased by 2.5%, with clinical and applied markets holding up well globally [18] - Diagnostics segment core revenue increased by 2%, with notable growth in clinical diagnostics outside of China [20] Market Data and Key Metrics Changes - Core revenues in developed markets were up low single digits, with North America slightly up and Western Europe up high single digits [11] - Core revenues in high growth markets were flat overall, with a mid single-digit decline in China [11] - Demand in China improved due to stimulus-related funding, translating into new customer orders and revenue [19] Company Strategy and Development Direction - The company is focused on delivering for customers while managing costs and investing in long-term growth initiatives [10] - Continued investment in innovation is emphasized, with several new product launches aimed at improving quality and efficiency [13][15] - The company maintains a strong balance sheet and free cash flow generation to enhance its portfolio [10][24] Management's Comments on Operating Environment and Future Outlook - Management noted that global trade tensions have created uncertainty, but market conditions were generally consistent with the first quarter [8] - The company expects core revenue growth of approximately 3% for the full year 2025, with adjusted diluted net EPS guidance raised to a range of $7.7 to $7.8 [23] - Management remains focused on navigating a complex macro environment while leveraging the Danaher Business System for continued strong results [24] Other Important Information - The CFO succession plan was announced, with Matt Gagino set to succeed Matt McGrew as CFO in February [5][6] - The company is addressing structural costs while continuing to invest in innovation for long-term growth [10] Q&A Session Summary Question: Can you provide more details on bioprocessing order trends? - Management indicated that consumables showed low double-digit growth driven by commercial demand, while equipment orders remain below historical trends [32][34] Question: How are global trade tensions affecting orders? - Trade uncertainty is causing delays in decision-making, particularly in pharma, but management expects this to clear in the next six to twelve months [36] Question: What are the assumptions for bioprocessing guidance? - High single-digit growth is still expected for bioprocessing, with pricing assumptions remaining stable [44][46] Question: Is the structural cost reduction plan complete? - Management is confident in achieving the targeted $150 million in structural cost reductions, with about half already realized [53] Question: How is the company viewing the biotech market? - The biotech market is currently at lower activity levels, but management sees AI as a potential tailwind for future growth [55] Question: What is the outlook for respiratory revenue? - The company maintains a respiratory revenue guide of $1.7 billion, with expectations for continued strong performance in non-respiratory segments [115]

Second Quarter 2025 Performance - Revenue increased to $5,936 million in Q2 2025, a 3.5% increase compared to $5,743 million in Q2 2024[5] - Core revenue growth was 1.5% and FX contributed 2.0% to revenue growth[5] - Adjusted diluted net earnings per common share increased by 4.7% to $1.80 in Q2 2025, compared to $1.72 in Q2 2024[5] - Adjusted operating profit margin remained flat at 27.3% in both Q2 2024 and Q2 2025[5] Segment Performance (Q2 2025) - Biotechnology revenue increased by 8.0% to $1,850 million, with core growth of 6.0% and FX contributing 2.0%[8] Adjusted operating profit margin increased by 150 BPS to 41.0%[8] - Life Sciences revenue increased slightly by 0.5% to $1,777 million, with core revenue declining by 2.5%, acquisitions contributing 1.5%, and FX contributing 1.5%[10] Adjusted operating profit margin decreased by 180 BPS to 19.3%[10] - Diagnostics revenue increased by 2.0% to $2,309 million, with core growth of 2.0%, divestitures reducing revenue by 0.5%, and FX contributing 0.5%[12] Adjusted operating profit margin decreased by 60 BPS to 26.1%[12] Guidance - The company forecasts low-single digit core sales growth for the three-month period ending September 26, 2025, compared to the same period in 2024[26] - The company forecasts 3.0% core sales growth for the year ending December 31, 2025, compared to 2024[26] - Adjusted operating profit margin is expected to be approximately 25.5% for the three-month period ending September 26, 2025[26] - Adjusted diluted net earnings per common share are projected to be between $7.70 and $7.80 for the year ending December 31, 2025[26] Cash Flow - Net cash provided by operating activities decreased by approximately 5.5% to $1,338 million for the three-month period ended June 27, 2025, compared to $1,417 million for the same period in 2024[52] - Free cash flow decreased by approximately 3.5% to $1,094 million for the three-month period ended June 27, 2025, compared to $1,131 million for the same period in 2024[52]

Core Viewpoint - INNOVATE Corp. will release its financial results for Q2 2025 on August 5, 2025, after market close, followed by an earnings conference call at 4:30 p.m. ET to discuss the results, operations, and strategy [1]. Group 1: Financial Results Announcement - The financial results for the second quarter of 2025 will be announced on August 5, 2025, after market close [1]. - An earnings conference call will take place on the same day at 4:30 p.m. ET to review the results and discuss operations and strategy [1]. Group 2: Conference Call Details - The conference call will be accessible via domestic dial-in at 1-877-704-4453 and international dial-in at 1-201-389-0920 [3]. - A replay of the conference call will be available approximately three hours after the call and can be accessed until August 19, 2025 [3]. Group 3: Company Overview - INNOVATE Corp. operates in three key areas of the new economy: Infrastructure, Life Sciences, and Spectrum [4]. - The company is committed to stakeholder capitalism and employs approximately 3,100 people across its subsidiaries [4].

Core Viewpoint - INNOVATE Corp. is initiating a series of refinancing transactions aimed at extending the maturities of its debt obligations, which includes exchanges of convertible and senior secured notes, as well as amendments to existing credit agreements [1][2][3]. Debt Refinancing Transactions - The company plans to exchange approximately $48.7 million of its existing 7.5% Convertible Senior Notes due 2026 for about $51.1 million of newly issued 9.5% Convertible Senior Notes due 2027 [2]. - An exchange offer has been launched for $330 million of 8.5% Senior Secured Notes due 2026, offering new 10.5% Senior Secured Notes due 2027 [3][4]. - The refinancing transactions are contingent upon the participation of at least 98% of the outstanding principal amount of the Existing Senior Secured Notes [7]. Agreements in Principle - The company has reached agreements in principle to extend the maturity of its 2020 Revolving Credit Agreement to September 15, 2026 [13]. - An agreement has been made to extend the maturity of the CGIC note to April 2027, with an interest rate of 16% [14]. - The maturity of Spectrum Notes is set to be extended to September 30, 2026, contingent on meeting certain strategic milestones [15]. - The maturity of R2 Technologies' note is proposed to be extended to August 1, 2026, with an interest rate of 12% [16]. Participation and Deadlines - The early participation deadline for the exchange offer is set for July 30, 2025, with the final settlement expected on August 15, 2025 [8]. - Supporting Noteholders, representing approximately 75.3% of the Existing Senior Secured Notes, have agreed to participate in the exchange offer [6].

Group 1 - The high cost of drug development, estimated at $1 billion from preclinical research to commercialization, remains a significant burden in the life sciences industry [1] - Model-Informed Drug Development (MIDD) is identified as a potential solution to reduce drug development costs [1] - The company ELAM1 provides financial professionals and investors with the necessary scientific and clinical expertise to navigate the complexities of the healthcare sector [1] Group 2 - ELAM1 aims to bridge the gap between advanced scientific research and financial strategy, helping clients uncover hidden value and assess risks more accurately [1]

Group 1 - Restart Life Sciences Corp. announced a non-brokered private placement of up to 10,000,000 common shares at a price of CDN$0.10 per share, aiming for gross proceeds of up to CDN$1,000,000 [1][2] - The offering is conducted under the listed issuer financing exemption and is available to purchasers in all Canadian provinces except Quebec, with no hold period for the shares issued [2][3] - Proceeds from the offering will be utilized for clinical studies and general working capital, and the offering may close in tranches, expected by August 21, 2025 [3] Group 2 - The company may pay finders fees in cash equal to 8.0% of the aggregate gross proceeds from the offering [3] - The securities issued will not be registered under the U.S. Securities Act and cannot be offered or sold in the United States without proper registration or exemption [4] - Restart Life Sciences Corp. is a Canadian-based life sciences company listed on the CSE, with more information available on its website [5]

Core Insights - Bio-Techne Corporation has entered into a distribution agreement with the U.S. Pharmacopeia (USP) to sell USP monoclonal antibody (mAb) and recombinant adeno-associated virus (AAV) reference standards, enhancing support for mAb and gene therapy development globally [1] - The need for consistent mAb quality is increasingly critical as patent protections expire and biosimilars emerge, necessitating rigorous testing of quality attributes during development and manufacturing [2] - Gene therapy, utilizing recombinant AAV, is rapidly growing but faces challenges such as low yields and high costs; USP reference standards provide benchmarks for analytical testing to ensure product quality [3] - USP mAbs and AAV reference standards can be used with Bio-Techne's analytical instruments, facilitating reliable characterization of complex biologics throughout the development process [4] - The collaboration between Bio-Techne and USP aims to address quality challenges in biotherapeutics, ensuring safety and efficacy for patient care [5] Company Overview - Bio-Techne Corporation is a global life sciences company that provides innovative tools and bioactive reagents for research and clinical diagnostics, generating approximately $1.2 billion in net sales in fiscal 2024 [6]

Core Viewpoint - Enzo Biochem, Inc. has entered into a Merger Agreement with Battery Ventures, which will acquire Enzo for $0.70 per share in cash, totaling approximately $37 million, following a strategic review to maximize shareholder value [1][2][3]. Summary by Sections Merger Agreement - The Merger Agreement was signed on June 23, 2025, and Battery Ventures will acquire Enzo for $0.70 per share, amounting to about $37 million [1]. - The purchase price represents a 75% premium over Enzo's closing price on April 22, 2025, and a 32% premium over the closing price on June 23, 2025 [2]. Strategic Committee Insights - The Board of Directors, through the Strategic Committee, conducted a thorough evaluation of options to maximize shareholder value and unanimously agreed that the all-cash offer from Battery provides immediate and compelling value [3]. - The transaction is subject to customary closing conditions, including shareholder approval, and is expected to close in the third quarter of the calendar year [3]. Post-Merger Status - Upon closing, Enzo will become a privately held company, and its shares will no longer be listed on public exchanges [4]. - BroadOak Capital Partners served as the financial advisor, and BakerHostetler LLP acted as legal counsel for the transaction [4]. Company Overview - Enzo Biochem has been a life sciences company for over 45 years, primarily operating through its Life Sciences division, focusing on labeling and detection technologies [5]. - The company offers a comprehensive portfolio of products, including antibodies, genomic probes, assays, biochemicals, and proteins, which are essential in translational research and drug development [5].

Core Insights - Bio-Techne's GMP reagents, including proteins and small molecules, are essential for its cell therapy offerings, with acquisitions playing a significant role in expanding its portfolio and entering adjacent markets [1] - The company is pursuing clinical diagnostic opportunities with its Ella platform, despite facing macroeconomic challenges that may impact operations [1][10] Financial Performance - Over the past year, Bio-Techne's shares have declined by 38.1%, underperforming the industry’s 15.3% decline, while the S&P 500 composite grew by 13.1% [2] - The company has a market capitalization of $7.63 billion, with earnings surpassing estimates in three of the last four quarters, averaging a surprise of 6.7% [2] Growth Drivers - The Cell and Gene Therapy segment is a major growth area, with the GMP reagents business experiencing high single-digit revenue growth in Q3 of fiscal 2025 and over 500 customers engaged in cell therapy development [3] - The GMP reagents business grew by just over 13% on a trailing 12-month basis, influenced by large, infrequent orders from late-stage clinical trials [3] - In China, the cell and gene therapy solutions are resilient despite funding challenges, with increasing adoption of organoid solutions expected to drive demand for GMP reagents [4] Strategic Initiatives - Bio-Techne has made several strategic acquisitions, including Lunaphore in fiscal 2024 and a 19.9% investment in Wilson Wolf, with plans to acquire the remaining ownership by the end of 2027 [5] - The launch of ProPak GMP Cytokines optimized for the Wilson WolfG-Rex bioreactor and an investment in Spear Bio for ultra-sensitive immunoassays highlight the company's focus on innovation [6] Market Opportunities - The Ella platform has received ISO 13485 certification and is being positioned for clinical diagnostics, with a partnership with Novomol-Dx to launch the BMP kit in India [7][9] - Ella is gaining traction among cell and gene therapy customers for viral titer and release testing, as well as among CROs for its high sensitivity and reproducibility [9] Challenges - The macroeconomic environment is causing increased raw material and labor costs, with a 2.8% rise in cost of sales and a 35.2% increase in selling, general, and administrative expenses year over year [10] - Funding challenges, particularly in China, are leading to extended sales cycles and production-related hazards, compounded by potential NIH funding cuts [11] Earnings Estimates - The Zacks Consensus Estimate for fiscal 2025 earnings has decreased by a cent to $1.88, while revenue estimates are pegged at $1.22 billion, indicating a 5.2% increase from the previous year [12]

Marc N. Casper Chairman, President and Chief Executive Officer Julia L. Chen Vice President and Corporate Secretary Annual Meeting of Shareholders 2025 The world leader in serving science Proprietary | May 21, 2025 Annual Meeting of Shareholders Meeting Agenda 2 Proprietary | May 21, 2025 • Call to Order and Instructions • Voting Matters • Questions and Answers on Voting Matters • Closing of Polls • Preliminary Voting Report • Management Presentation • Questions and Answers on General Matters • Adjournment ...