胶原蛋白填充剂因其改善面部美观的能力和非侵入性特性，正成为继玻尿酸之后又一种受追捧的医美 填充剂品类。从胶原蛋白成分来源，可分为动物源性胶原蛋白和重组胶原蛋白。从一些已上市的胶原 蛋白填充剂企业来看，销售毛利率可超过八成，但面对如此多的胶原蛋白填充剂涌入市场，行业高毛 利的趋势能否维持？ 2026.02. 13 本文字数：1655，阅读时长大约3分钟 作者 | 第一财经 林志吟 "以前是没得选，现在是不知道怎么选。"有人用这句话来形容当前的胶原蛋白填充剂市场竞争现 状。 今年以来，奇璞生物、巨子生物这两家公司相继有胶原蛋白填充剂产品拿到医疗器械三类注册证。 按照中国监管要求，玻尿酸、胶原蛋白、再生材料及其他新型注射材料需要获得国家药监局三类医疗 器械注册证。从去年以来，共有9款胶原蛋白填充剂产品顺利拿到了三类注册证，这一数量超过了过 去获批的总数。换言之，胶原蛋白三类注册证变得不那么稀缺。 "在高端医美机构与三甲医院，消费者满意度集中于'自然效果'与'维持时间'两大维度。而在下沉市 场，价格敏感型用户占比提升。核心消费群体已初步形成'年龄+问题部位+预算=适合品牌'的认知框 架。医生端作为关键决策节点，其处方 ...

Core Insights - The Chinese beauty market is experiencing significant growth driven by ingredient-focused marketing, but there is a widening gap between consumer expectations and regulatory standards [1] - The complexity of new ingredients like bioactive peptides and plant extracts has outpaced existing national standards, leading to regulatory challenges [1][7] - Social media's promotion of high-concentration ingredients has resulted in consumer misconceptions about safety and efficacy, increasing the risk of health issues [1] Group 1: Medical Applications - Hyaluronic acid (HA) is primarily used for facial filling and shaping, addressing issues like wrinkles and volume loss, while collagen is crucial for skin firmness and elasticity [2][3] - HA provides immediate results and strong moisturizing effects, but its effects last only 6-12 months, requiring regular maintenance [4] - Collagen injections take longer to show results (1-2 weeks) but can stimulate the body's own collagen production, with effects lasting 6-18 months or longer [5] Group 2: Market Dynamics - HA dominates the aesthetic filler market due to lower production costs and widespread application, while collagen's market share is smaller but growing faster [8][9] - The production cost of collagen is 3-5 times higher than that of HA, which contributes to its higher retail price [8] - High prices for collagen may slow its market penetration, particularly in emerging markets, but some consumers view the cost as a reflection of quality [9] Group 3: Regulatory and Testing Standards - Current testing methods for HA include high-performance liquid chromatography (HPLC) and gel permeation chromatography (GPC), while collagen is tested using methods like the Kjeldahl method and BCA assay [6][7] - Regulatory focus is on purity, molecular weight distribution, and biological safety, with HA standards being more established than those for collagen [7] - The rapid development of new materials outpaces the evolution of traditional quality standards, posing challenges for regulatory compliance [7] Group 4: Future Trends - The next five years may see increased integration of HA and collagen in applications aimed at improving skin hydration and elasticity [10] - Innovations in synthetic biology could lead to breakthroughs in the use of collagen in tissue engineering and regenerative medicine [10] - As competition intensifies, prices for both HA and collagen products may decrease, driven by technological advancements and market entry of new players [11]