Group 1: Optical Tweezers (OT) - Optical tweezers, invented by Arthur Ashkin in 1986, utilize laser light to manipulate microscopic objects without physical contact, minimizing damage to biological samples [4][5] - The technology has evolved over 40 years, expanding its application from micron-sized spheres to atomic and nanoscale objects, and is now a key tool in cell manipulation and biophysical research [4][5] - Major applications include single-molecule biology, assisted reproduction, and capturing rare cells, with companies like Changguang Chenying and Catcher representing the domestic market [5][10] Group 2: Optical Electric Tweezers (OET) - Optical electric tweezers, inspired by optical tweezers, were developed in 2005 and commercialized by Berkeley Lights in 2011, later acquired by Bruker in 2023 [2][17] - OET technology generates non-uniform electric fields to manipulate particles, allowing for high-throughput applications in cell sorting, analysis, and drug delivery [15][19] - The technology faces high barriers to entry due to complex know-how and high R&D costs, with few companies successfully commercializing it [17][18] Group 3: Industry Trends and Future Prospects - The integration of OET with microfluidics is transforming biopharmaceutical research, enabling high-throughput screening and antibody development [19][20] - Future trends include the automation of processes through AI, the introduction of new materials for better biocompatibility, and modular integration for compact systems [20] - Companies like Micronano Power and Catcher are leading innovations in the field, with products that enhance precision and efficiency in cell manipulation [23][12]