撰文丨王聪 编辑丨王多鱼 排版丨水成文 内质网 （ER） 容纳了多种对细胞稳态和健康衰老至关重要的细胞过程，包括蛋白质质量控制、脂质生物合成、自噬启动、碳水化合物代谢和钙信号转导。内质 网还通过一系列可塑的细胞器间接触位点协调细胞内信号转导和其他多种膜结合细胞器的形态动力学。通过将多种营养感知途径与其促进分泌的作用相结合，内 质网的状态也是多细胞生物健康细胞间信号转导的关键决定因素。 内质网在细胞和生物体生理学中的这种核心地位，凸显了该细胞器在健康衰老与病理性衰老轨迹中的关键驱动作用。 2026 年 2 月 2 日， 范德堡大学医学院的研究人员在 Nature 子刊 Nature Aging 上发表了题为： ER remodelling is a feature of ageing and depends on ER- phagy 的研究论文。 该研究表明， 内质网重塑 （ ER remodelling ） 是 衰老 的一个显著特征，并且其依赖于 内质网自噬 （ ER-phagy ） 。 内质网 （ER） 由一系列亚区组成，每个亚区都具有独特的结构和功能。尽管内质网过程的改变与年龄相关发病机制有关，但尚不清楚 ...

Core Insights - A new study published in "Nature Cell Biology" reveals that human cells can change their shape to close wound gaps, providing insights into cellular self-repair mechanisms and potential applications in wound healing and tissue regeneration [1] Group 1: Cellular Mechanisms - Epithelial cells, which cover internal and external surfaces of the body, play a crucial role in protecting against physical damage, pathogen invasion, and water loss [1] - The endoplasmic reticulum (ER) in epithelial cells alters its shape in response to wound curvature; it forms tubular structures at convex curves and flat sheet-like structures at concave curves [1] Group 2: Cellular Movement - The driving force at the edges of convex curves and the pulling force at concave curves change the shape of the endoplasmic reticulum through different mechanisms [1] - At the edges of convex cracks, cells extend flat membrane structures through "crawling" movements to fill the gap, while at concave edges, cells contract the edges through "tethering" movements, akin to tightening a rope to close the gap [1] Group 3: Role of Endoplasmic Reticulum - The endoplasmic reticulum reorganizes itself based on the curvature of the wound edges, influencing the migration patterns of epithelial cells, highlighting its critical role in cellular behavior [1]