Core Findings - The study published in Nature Medicine demonstrates that the timing of immunochemotherapy significantly affects treatment efficacy in patients with non-small cell lung cancer (NSCLC) [3][4] - Administering treatment before 3 PM leads to a longer progression-free survival (PFS) and overall survival (OS) compared to treatment after 3 PM [7][10] Study Design - The randomized phase 3 trial included 210 treatment-naive patients with advanced NSCLC, who were assigned to receive immunochemotherapy either before or after 3 PM, with a median follow-up of 28.7 months [4][7] Efficacy Results - Patients receiving treatment before 3 PM had a median PFS of 11.3 months, while those treated after 3 PM had a median PFS of 5.7 months, indicating a 60% reduction in the risk of disease progression (HR = 0.40) [7][9] - For overall survival, the early treatment group had a median OS of 28.0 months compared to 16.8 months for the late treatment group, reflecting a 58% reduction in mortality risk (HR = 0.42) [7][9] Immunological Insights - The study found that patients treated in the morning had a higher count of CD8+ T cells in circulation, which are crucial for targeting cancer cells, compared to those treated in the evening [9] - Additionally, the ratio of activated CD8+ T cells to exhausted CD8+ T cells was more favorable in the morning group, suggesting stronger anti-tumor immune functionality [9] Safety Profile - Adverse events were similar between both groups, with no new safety concerns identified, indicating that changing the timing of administration does not increase treatment toxicity [10] Implications for Clinical Practice - This research provides strong prospective evidence for "chronotherapy," suggesting that optimizing treatment timing can significantly enhance the effectiveness of immunochemotherapy without additional costs or drug modifications [10]

大咖聚首｜宠 界"奥斯卡"平行 论坛聚焦解 锁"老baby"健康 密码_南方+_南 方plus 2026年1月23 日，"媒体+"首 届大湾区宠物行 业年度盛典期 间，以"老年宠 物健康"为主题 的研讨会成功举 办。来自肿瘤医 学、传染病防 控、基因检测、 兽医学等领域的 6位专家学者齐 聚，围绕老龄宠 物肿瘤防治、肥 胖管理、传染病 防控及基因检测 技术应用等核心 议题，展开深度 研讨。 随着国内首批宠 物步入老年，老 龄宠物健康问题 备受关注。数据 显示，宠物与人 类老龄疾病相似 度较高，肿瘤是 老龄宠物的首要 致死疾病——超 50%的老年犬最 终死于肿瘤， 30%以上的老年 猫会被检出肿 瘤，美国每年更 有600万只宠物 因癌症离世。 广州百思动物医 院主任兽医师佘 源武指出，临床 中宠物肿瘤病例 呈显著增长趋 势，但多数病例 确诊时已至晚 期，治愈难度较 大。"肿瘤治愈 率与其发病部 位、类型密切相 宠物肥胖与老年 健康的关联的成 为研讨会热点。 临床中，宠物与 主人体态趋同的 现象较为普遍， 而宠物肥胖多源 于主人喂养自律 性不足。中国农 业科学院上海兽 医研究所研究 员、伴侣动物生 物安全风险预警 ...