Core Insights - The research team at the Chinese Academy of Sciences has developed an engineered nanoenzyme that responds to deep red light or ultrasound, transforming proximity labeling technology into a powerful therapeutic tool [1][2] - The study, published in the journal Nature, demonstrates that artificially increasing antigen density on tumor cells can significantly enhance immune recognition and killing efficiency [1][2] Group 1 - The engineered nanoenzyme creates a strong artificial target on cancer cells, which allows for the effective aggregation of T cell receptors, triggering a potent attack mode against the targeted area [2] - In mouse experiments, the tumor volume was reduced by over 80%, and the immune system was activated to suppress untreated distant tumors, indicating a systemic anti-tumor effect [2] - Long-term studies show that cured mice exhibit complete immunity to secondary tumor challenges, suggesting the induction of long-lasting immune memory akin to vaccination against tumors [2] Group 2 - The research indicates that the new method significantly improves immune activation and killing efficiency compared to traditional antigen amplification methods [2] - The study's findings open new avenues for developing smarter and more efficient next-generation immunotherapies [2]