Core Viewpoint - The research teams from Heilongjiang Academy of Agricultural Sciences and Sun Yat-sen University have successfully developed the world's first single-gene and multi-gene edited Min pigs, marking a significant advancement in genetic editing for livestock breeding [1] Group 1: Single-Gene Editing Achievements - The teams achieved single-gene editing of the IGF2 gene, resulting in Min pigs with improved meat quality [1] - They also edited the BMP15 gene, leading to Min pigs with enhanced reproductive capabilities [1] Group 2: Multi-Gene Editing Achievements - The teams combined the BMP15, MSTN, and CD163 genes to create three-gene edited Min pigs that exhibit increased production, high reproductive capacity, and disease resistance [1] - Another combination of the TYR, SGK3, and GHRHR genes resulted in three-gene edited Min pigs characterized by hairlessness, albinism, and dwarfism [1] Group 3: Broader Implications and Future Research - The research also included the Five-Finger Mountain pig, resulting in growth-related PROP1 gene edited pigs and high reproductive capacity FecB gene edited pigs [1] - The findings provide new pathways for high-quality Min pig production and open new avenues for the breeding of medical model pigs and pet pigs, indicating significant theoretical and practical implications [1] - The teams plan to enhance trait evaluation of gene-edited pigs and continue research on other gene-edited pigs, contributing to the protection of local pig resources and the development of the life and health industry in China [1]

11月7日，记者从黑龙江省农业科学院获悉，该院教授刘娣团队与中山大学何祖勇团队联合攻关，以国家级保护猪种民猪为对象，成功培育世界 首批单基因和多基因编辑民猪20头。 刘娣表示，团队将进一步加强基因编辑猪的性状评估并继续开展其他基因编辑猪的研究，推动该成果迈向产业应用，为我国地方猪种资源保 护、新种质创制和生命健康产业发展注入新动能。 （文章来源：科技日报） 项目组先后于2024年11月8日和2025年7月25日，在黑龙江省农业科学院实验猪场获得两批20头民猪的基因编辑猪。项目首次以民猪为对象，分 别获得了具有提高肉质效应的IGF2基因编辑猪；具有提高繁殖力的BMP15基因编辑猪。在多基因组合编辑方面，将BMP15、MSTN、CD163三 个基因组合编辑，获得具有增产、高繁殖力、抗病效应的三基因编辑猪；同时，将TYR、SGK3、GHRHR三个基因组合编辑，获得具有无毛、 白化、矮小效应的三基因编辑猪。此外，团队还以五指山猪为对象，成功获得生长相关PROP1基因编辑猪、高繁殖力FecB基因编辑猪。 该研究成果，标志着团队在利用民猪进行基因编辑方面走在国际前列，不仅为优质高效民猪生产提供了基因编辑育种新路径，更为医 ...