小动物全身亚细胞分辨率三维成像技术

Search documents
【科技日报】小动物全身亚细胞分辨率三维成像技术研发成功
Ke Ji Ri Bao· 2025-07-30 01:17
Core Viewpoint - The research team from the University of Science and Technology of China has developed the world's fastest subcellular resolution 3D imaging technology for small animals, enabling the first detailed 3D mapping of the entire neural network in mice, which provides a new tool for studying peripheral nerve regulation networks and disease mechanisms [1][2]. Group 1 - The innovative imaging technology functions like a "super CT scanner" for small animals, completing full-body imaging of adult mice in just 40 hours, generating approximately 70TB of raw image data, equivalent to thousands of HD movies [2]. - The efficiency of this imaging technology has improved several to dozens of times compared to existing methods, with resolution enhanced from tissue-cell level to uniform subcellular level, allowing clear capture of individual nerve fibers with diameters of a few micrometers [2]. - This breakthrough enables precise analysis of the 3D connectivity of different types of peripheral nerves, including cranial, spinal, and autonomic nerves, providing technical support for mapping central-peripheral nerve structures and understanding disease mechanisms [2]. Group 2 - The technology is expected to address numerous unresolved questions in neurobiology, developmental biology, anatomy, and biomedicine, and can be applied in biomedical research and disease mechanism analysis, laying a solid foundation for the development of precise neural regulation therapies in the future [2].