Core Viewpoint - The research conducted by the team at Northwestern Polytechnical University aims to establish a unified computational physics evaluation system for blood rheology, addressing the complexities of non-Newtonian fluid behavior in blood flow simulations, which is crucial for cardiovascular disease diagnosis and thrombus risk prediction [3][6]. Group 1: Non-Newtonian Fluid Characteristics - Non-Newtonian fluids exhibit different behaviors under varying forces; for instance, they can behave like solids under high shear rates and like liquids under low shear rates, a phenomenon known as "shear thickening" [1]. - Blood, as a non-Newtonian fluid, demonstrates "shear thinning" behavior, where its viscosity decreases with increased flow rate, facilitating smooth circulation in blood vessels [1]. Group 2: Research Contributions - The study systematically reviews 140 core research findings since 1919 to create a comprehensive evaluation system that includes characteristics such as shear thinning, viscoelasticity, and yield stress, providing a reference for researchers in selecting computational models [3][6]. - The research identifies a scientific boundary for the non-Newtonian characteristics of blood, indicating that above a certain threshold, blood behaves like a Newtonian fluid, while below it, particularly in areas like aneurysms or narrowed vessels, it exhibits significant non-Newtonian properties [6]. Group 3: Computational Methods - The research evaluates different computational approaches for simulating blood flow, including the bidirectional fluid-structure interaction (FSI) methods and the arbitrary Lagrangian-Eulerian (ALE) method, highlighting the challenges of mesh reconfiguration in large deformation scenarios [7]. - To overcome computational limitations, the study introduces the Smoothed Particle Hydrodynamics (SPH) method, which avoids mesh distortion and enhances flexibility in handling large deformations, thus improving the accuracy of multi-phase physical interface tracking [7]. Group 4: Implications for Medical Applications - The findings provide a theoretical foundation for constructing high-precision patient-specific models, which can significantly advance precision medicine by enabling more accurate simulations of blood flow and vessel behavior in clinical settings [7].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在人类早期胚胎发育过程中， 合子基因组激活 （ZGA） 是一个关键事件，在此期间胚胎开始从自身基因 组转录。这一过程需要对染色质景观和转录网络进行全局性重排。ZGA 失败常常导致发育停滞，这是导致 不孕和妊娠失败的一个主要因素。尽管对哺乳动物 ZGA 模型的研究已经确定了对 ZGA 网络至关重要的关 键蛋白质编码基因，但人类 ZGA 失败和早期妊娠失败的原因仍知之甚少，这可能反映了物种间存在显著的 调控差异。 2026 年 1 月 22 日，浙江大学医学院 梁洪青 、 张丹 团队，联合同济大学 高绍荣 院士及浙江大学爱丁堡 大学联合学院 刘琬璐 团队 （ 向阳泉 、 钱羽力 、 李铮一 、 王佳旭 为论文共同第一作者） ， 在国际顶 尖学术期刊 Science 上发表了题为： Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development 的研究论文。 该研究表明，一种古老的病毒残留物—— 内源逆转录病毒 MLT2A1 ，在 ...

Core Insights - Organoid technology is a revolutionary model in life sciences, showing great potential in simulating human organ development, disease mechanism research, and drug development, but faces significant bottlenecks in scaling and standardization [1] - Current organoid research needs to move beyond traditional morphological observations to deeper functional analyses, particularly in assessing cellular energy metabolism, which is crucial for evaluating organoid viability, drug toxicity, and metabolic disease phenotypes [1] - The reliance on manual operations and animal-derived matrix gels in organoid culture leads to significant sample variability and high costs, hindering high-throughput drug screening applications [1] Group 1 - A single technical pathway is insufficient to address systemic issues in organoid research; a cross-platform, multidimensional technical collaboration is necessary to create an integrated solution from model establishment to standardized culture and deep functional characterization [2] - Agilent, in collaboration with Instrument Information Network, will host a webinar on January 21, 2026, titled "Multidimensional Technological Innovation and New Paradigms in Organoid Research," inviting leading scholars and technical experts to discuss pathways for standardized organoid research [2] Group 2 - The agenda for the webinar includes presentations from distinguished guests, such as: - "Construction of Functional Organs Based on Organoid Assembly and Precision Medicine Research" by Dr. Pang Yuan from Tsinghua University [6] - "Instantaneous Dynamics of Organoid Metabolism: Standardized Application of Seahorse XF in 3D Models" by Wei Yufeng from Agilent Technologies (China) [7] - "Multi-modal Automation Platform Compatible with Phenotype and Viability Analysis to Assist in Standardized Organoid Model Establishment" by Yang Jingzhe from Agilent Technologies (China) [7] - "Construction and Application of Engineered Multi-organ Chips: From Absorption Metabolism to Tumor Immune Regulation" by Liu Dongdong from the Chinese Academy of Sciences [7]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 衰老 是一个复杂的过程，会影响各种组织和器官，同时伴有衰老细胞的积聚。衰老细胞表现出增殖不可逆停滞以及对程序性细胞死亡的抵抗。重要的是，衰老细 胞能够分泌多种促炎细胞因子、趋化因子和组织重塑蛋白，这些统称为 衰老相关分泌表型 （SASP） 。 SASP 已被证实与衰老相关的退行性疾病发病机制有关，已有大量证据表明，通过药物或基因手段清除衰老细胞 （也被称为 Senolytics ） 是一种有效的抗衰老 方法。近年来，新研发的 Senolytics 药物已被证实能够特异性地清除衰老细胞，且副作用较小。 但目前尚不清楚 低气压 （Hypobaric Pressure，HP） 是否能 够诱导衰老细胞死亡。 衰老细胞 的积聚会导致 衰老 ，清除这些衰老细胞是一种有效的抗衰老策略。目前的抗衰老策略侧重于药物介导的衰老细胞清除，尚不清楚 低气压 条件是否能够 诱导衰老细胞死亡。 低气压 （HP） 是指低于标准大气压的相对压力状态，它既是高海拔地区的自然条件，也存在于人体内部。人体内低气压的分布是生物进化与适应性的重要体 现。低气压对于维持心脏、肺、腹腔、胃肠道及关节的基本生命活动至 ...

Core Insights - Shenzhen Medical Academy of Research and Translation (SMART) aims to pave new paths in future medical science by fostering original innovation and developing a top-tier talent team to address urgent challenges in healthcare [3] - SMART employs a comprehensive approach to break down barriers between clinical medicine, basic research, and industrial transformation, positioning Shenzhen as a hub for biomedical science [3] Group 1: Organizational Overview - SMART is dedicated to transforming scientific technology into public health, emphasizing the importance of innovation in biomedical research [3] - The organization is rooted in Shenzhen and aspires to make the city a gathering place for talent and a powerful force in global biomedical science [3] Group 2: Job Overview - The i-BRAIN Nanofabrication Facility at SMART is a world-class international facility supporting cutting-edge brain-computer interface (BCI) and neurotechnology research [6] - The facility is seeking proactive senior engineers to lead in one of four technical areas, focusing on process development, tool operation, and user training [6] Group 3: Responsibilities and Qualifications - Key responsibilities include process development and optimization, equipment operation and maintenance, and collaboration for facility support [9][10] - Candidates should have a bachelor's degree or higher in relevant fields, with a minimum of 5 years of hands-on experience in cleanroom environments and expertise in areas such as EBL, DUV Stepper, Photolithography, or PVD/Metrology [13][11] Group 4: Benefits of Joining - Joining SMART offers the opportunity to contribute directly to transformative BCI and medical device development, work with advanced lithography and deposition systems, and be part of a global team shaping the future of neurotechnology [18]

Core Viewpoint - Westlake Laboratory, established in July 2020, focuses on breakthroughs in life sciences and biomedicine, particularly in aging-related diseases and cancer research [3]. Group 1: Recruitment Information - Westlake Laboratory is publicly recruiting for multiple tenure-track positions across all academic levels, encouraging scholars with expertise in aging and neurodegenerative fields to apply [5]. - Applicants must hold a PhD or equivalent degree, have an outstanding research record, innovative future research plans, and a commitment to teaching excellence and diversity [5]. Group 2: Benefits and Resources - Successful applicants will receive competitive salaries and benefits, substantial startup funding, modern laboratory space, and access to advanced core facilities, including cryo-electron microscopy and mass spectrometry [6]. - The laboratory has developed a supportive and vibrant research community aimed at exploring fundamental biological and disease-related questions, developing advanced technologies for human health, and nurturing the next generation of research leaders [6]. Group 3: Application Requirements - Applicants are required to submit a cover letter outlining their research goals, significant achievements, and relevant experience [8]. - A complete academic CV and a research summary statement (maximum 1 page) along with a research proposal (maximum 3 pages) must also be included [9][10]. - Candidates for the assistant professor position must arrange for three referees to send recommendation letters directly [11].

撰文丨 编辑丨王多鱼 排版丨水成文 严重的呼吸道病毒感染会导致肺泡上皮细胞广泛受损，并引发强烈的免疫反应。免疫微环境如何与肺干细 胞/祖细胞相互作用并影响肺泡再生，目前尚不清楚。 2025 年 12 月 23 日，上海科技大学生命科学与技术学院 席莹 教 授团队 （ 陆甜甜 、 刘莉 、 王萍 为论 文 共同第一作者 ） 联合上海交通大学医学院附属 第六人民医院 任涛 教授、广州医科大学/广州实验室 赵 金存 教授，在 Cell Stem Cell 期刊 发表 了 题为： Dysplastic epithelial repair promotes the tissue- residence of lymphocytes to inhibit alveolar regeneration post viral infection 的研究论文。 该研究首次揭示了肺组织中异常修复的 KRT5 基底样细胞 对 T 细胞 组织驻留 的促进作用，同时发现流感 病毒清除后持续存在的 T 细胞会 抑制气道 Club 细胞介导的 肺泡 再生 。该研究 深化了对严重病毒感染后 肺修复 再生 障碍的机制认识， 也为促进感染后肺泡再生 ...

编辑丨王多鱼 排版丨水成文 在过去十多年里， 肝脏类器官 研究突飞猛进。从最初基于小鼠或有限人源组织的上皮类器官模型，到如今 不断演进的多细胞共培养体系，科学家们始终在向一个终极目标逼近 —— 在体外真正复刻成年人体肝脏的 结构与功能 。 然而，一个核心难题始终横亘在前： 如何在体外长期、稳定地维持成人肝脏的多细胞复杂性？ 真实的人体肝脏并非单一细胞构成，而是由 肝细胞 、 胆管上皮细胞 、 成纤维细胞 等多种细胞类型共同 组成，并在精细的空间结构中协同工作。遗憾的是，长期以来，大多数肝脏类器官模型仍停留在 " 单一上 皮细胞 " 的层面，难以重建这种复杂而关键的细胞互作网络。 该研究 首次在体外成功重建了 人类肝脏门区的多细胞结构与功能特征 ，构建出一种可长期维持、具备高 度生理相关性的人源肝脏 " 组装体" （ assembloid） 模型。 现有的人体肝脏体外模型 —— 无论是 原代人肝细胞 （ PHH ） ，还是 iPSC 来源的肝细胞类器官 —— 都存在难以回避的局限： 相比之下，小鼠来源的多细胞类器官模型已初露曙光，但 在人类体系中重现具有生理相关性的多细胞肝组 织，依然是一个悬而未决的挑战 。 ...

编辑丨王多鱼 排版丨水成文 深圳医学科学院 （Shenzhen Medical Academy of Research and Translation，SMART） ， 是一家为 未来医学科学开辟新道路的机构。SMART 致力于探索最能激发原始创新的新机制，同时培养一支能够应对 紧迫挑战的顶尖人才团队。在 SMART，将科学技术转化为全民健康是我们工作的核心。SMART 采用全过 程方法，不断突破生物医学研究的界限， 打通临床医学、基础研究、产业转化等环节之间的障碍 。扎根深 圳，SMART 敢于梦想，致力于将深圳建设成为人才汇聚的智慧之城和全球生物医学科学的强大力量。 感染与免疫是 深圳医学科学院 （SMART） 及其姊妹机构 深圳湾实验室 （SZBL） 的重点研究方向。 此次将招聘多位主要在 SMART 人类免疫学研究所任职的教职人员，研究重点包括但不限于微生物致病 性、病原体与宿主的相互作用、T 细胞和 B 细胞生物学、病毒免疫学以及系统免疫学。 福利待遇 欲了解更多关于 SMART 的信息，请访问网站：https://smart.org.cn/en/ 。 招聘职位与资格条件 资深研究员 （ Senio ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 哺乳动物的大脑包含多种神经元和免疫细胞类型，这些细胞会因不同的细胞外环境而表现出动态的运动。然而，技术上的限制使得在活体中研究发育中大脑的复 杂细胞运动变得困难。 而现在，一项来自清华大学的新技术—— IMEE ，让我们得以直观的长时间观察 大脑构建过程中细胞之间的精密互动， 就像观看一场生命初始的"细胞华尔兹"， 让活体胚胎大脑中的细胞之舞首次尽收眼底。 2025 年 12 月 16 日，清华大学生命科学学院 米达 团队与清华大学基础医学院 郭增才 团队合作 （ 博士生 龙真 、 于永震 和 贺辰祎 为论文共同第一作者 ） ，在国际顶尖学术期刊 Cell 上发表了题为： Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain （哺乳动物发 育大脑中神经元与免疫细胞动态的活体观察） 的研究论文。 该研究开发了一种高稳定性、多视角、长时程的胚胎小鼠宫内活体成像技术—— IMEE （ intravital imaging of external ...