Core Viewpoint - A research team from the Chinese Academy of Sciences has developed a novel proximity labeling technology that significantly enhances the precision of targeting cancer cells, potentially leading to more effective cancer immunotherapy [1][2]. Group 1: Research Development - The proximity labeling technology allows scientists to accurately identify the "social circle" of specific molecules, effectively tagging their neighbors [1]. - The research team has engineered a nanoenzyme to transform this labeling technology into a therapeutic tool, demonstrating significant efficacy in mouse tumor models and patient samples related to breast, gastric, and colorectal cancers [1]. Group 2: Treatment Mechanism - In cancer immunotherapy, this method can enhance the effectiveness of immune cell attacks by tens to hundreds of times, addressing the challenge of sparse natural signals on cancer cell surfaces [2]. - The engineered nanoenzyme can create a strong artificial target on cancer cells using red light or ultrasound, triggering a powerful attack mode for precise targeting [2]. Group 3: Future Implications - This research is expected to pave the way for the development of smarter and more efficient next-generation immunotherapies [3].