Investment Rating - The report maintains a "Buy" rating for the industry, indicating an expected investment return exceeding 15% over the next 6-12 months [49][56]. Core Insights - The report identifies a turning point in the innovative drug industry, driven by overseas growth and the opening of the domestic market, suggesting a significant growth phase ahead [34]. - The industry is transitioning from capital-driven to profit-driven growth, with a dual recovery in performance and valuation expected [47][49]. - Key factors include the commercialization of innovative products, the acceleration of clinical data breakthroughs, and the introduction of supportive payment policies [50][49]. Summary by Sections Section 1: Validation of the Turning Point in the Innovative Drug Industry - The innovative drug industry in China is entering a recovery phase, characterized by a "profit year" and the implementation of supportive payment policies [5][10]. - The report highlights a significant increase in the number of innovative drug companies achieving over 500 million yuan in revenue, indicating a robust growth trajectory [21][22]. - The domestic market for innovative drugs is projected to reach a scale of 1 trillion yuan by 2035, with innovative drugs expected to account for 30% of the market [30][32]. Section 2: Core Technology Cycle Configuration - The next generation of immunotherapy is anticipated to drive a new round of biotechnology cycles, with a focus on product strength and clinical demand [37][40]. - The report emphasizes the importance of selecting stocks based on technology cycles, product strength, and clinical needs [44]. Section 3: Investment Recommendations - The report suggests focusing on pharmaceutical companies transitioning to innovation, which are expected to see performance and valuation increases [50]. - It also highlights biotech companies with validated research platforms and potential for overseas product registrations as key investment opportunities [50].

Innovent Biologics Overview - Innovent Biologics has grown into a China-leading biopharmaceutical company with 16 commercial products and 21 clinical pipeline products[9,10] - Innovent's total revenue exceeded RMB9.4 billion in 2024, marking a 55% increase from the previous year[26,27] - Product revenue is projected to achieve RMB20 billion in 2027[38] Oncology Drug Development in China - China accounted for 35% of the global oncology trials in 2023, exceeding the US[172] - The share of first-approved innovative drugs developed by China rose significantly from 4% in 2015 to 38% in 2024[175] - In the first half of 2025, Chinese pharmaceutical companies executed 20 oncology out-licensing deals totaling nearly $30 billion, with ADCs remaining a key focus[185,187] IBI363 (PD-1/IL-2 α-bias) Clinical Progress - IBI363 is a global first-in-class next-generation IO therapy designed to selectively activate and expand tumor-specific T cells[158,159] - In IO-resistant squamous cell lung cancer, IBI363 at 3 mg/kg showed a confirmed ORR of 36.7% and a median PFS of 9.3 months[160] - In IO-resistant melanoma, IBI363 showed an ORR of 26.7% and a median DoR of 14 months[531,533] - In 3L+ CRC, IBI363 monotherapy achieved a median OS of 16.1 months, and IBI363 + Bevacizumab combination therapy showed a cORR of 15.1%[647,650] ADC Developments in Gastrointestinal Cancers - HER2 ADCs demonstrated remarkable efficacy in HER2 3+ CRC, with T-DXd showing a 57.5% ORR and IBI354 showing a 54% confirmed ORR in earlier-phase trials[203,204] - IBI343, a CLDN18.2 ADC, showed promising efficacy in 3L gastric cancer, with the 6 mg/kg group achieving an ORR of 36.7% and a median PFS of 6.8 months[214,217] - In advanced pancreatic cancer, IBI343 showed an ORR of 22.7% in CLDN18.2-high (IHC ≥60%) population, with mPFS of 5.4 months and mOS of 9.1 months[220,224]