Core Viewpoint - Aging is a major risk factor for various neurodegenerative diseases, including Alzheimer's disease, and is associated with the accumulation of senescent cells that propagate the aging process through paracrine signaling [2] Group 1: Research Findings - The research published in Nature Aging demonstrates that border-associated macrophages (BAM) regulate cognitive aging by inducing paracrine senescence in microglia through migrasome-mediated mechanisms [4][8] - In the early stages of brain aging, BAM acquire senescence-related characteristics, potentially due to prolonged exposure to beta-amyloid (Aβ) [7] - Senescent-like BAM exhibit increased production of migrasomes, which transmit aging-related signals to neighboring cells, particularly microglia, inhibiting their apoptosis and promoting senescence induction [8] Group 2: Intervention Strategies - The research team developed intervention strategies targeting migrasome production by delivering siRNA to block Tspan4, which can improve cognitive deficits in aged mice [8] - These findings suggest that migrasomes are powerful carriers of aging regulatory signals and represent a promising target for Senomorphic therapies, which aim to inhibit the senescence-associated secretory phenotype without affecting cell death [8]