Core Insights - A research team from the Chinese Academy of Medical Sciences has confirmed that the combined use of three common cytokines can effectively disrupt the internal structure of pancreatic cancer cells, leading to their destruction, thus providing a new approach for pancreatic cancer treatment [1][2] Group 1: Research Findings - Pancreatic cancer, known as the "king of cancers," is highly malignant and difficult to treat due to a long-standing lack of effective treatment methods [1] - The research team discovered that pancreatic cancer cells form a protective mucous layer that allows them to evade immune cell attacks and resist the body's digestive enzymes, which is a significant reason for the treatment challenges [1] - The three cytokines work synergistically like a "demolition team," with interferon gamma guiding key pore-forming proteins to the cancer cells' lysosomes, interferon beta providing the activation tools, and transforming growth factor beta acting as a stabilizer to maintain the activation state of the pore-forming proteins [1] Group 2: Treatment Mechanism - The pore-forming proteins create holes in the lysosomal membrane, leading to the complete destruction of the cancer cells from within [1] - The study also suggests that lipid nanoparticle carriers can precisely deliver the messenger RNA of these three cytokines to the tumor site, enhancing treatment efficacy while minimizing damage to normal tissues [1] - This method selectively targets and kills more malignant pancreatic cancer stem cells, showcasing the advantages of precision therapy [1]